Vitamin C supplementation prevents testosterone-induced hyperplasia of rat prostate by down-regulating HIF-1α

Li, Shan Hua; Ryu, Ji Hye; Park, Sook Eun; Cho, Young Suk; Park, Jong-Wan; Lee, Wang Jae; Chun, Yang Sook

doi:10.1016/j.jnutbio.2009.06.004

Cited by 26 publications

(24 citation statements)

References 28 publications

(25 reference statements)

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“…Administration of vitamin C can reduce significantly HIF-1a levels. Mechanistically, vitamin C is likely to repress HIF-1a by stimulating the enzymatic action of PHD2 (Li et al, 2010). Although we found a tendency to decrease in the plasma Epo levels in the group of animals treated with vitamin C and submitted to hypoxia (See Fig.…”

Section: Vitamin C and Erythropoiesismentioning

confidence: 65%

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Vitamin C Supplementation Does not Improve Hypoxia-Induced Erythropoiesis

Martínez-Bello

Sanchís-Gomar

Martinez‐Bello

et al. 2012

High Altitude Medicine & Biology

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a. Vitamin C Supplementation Does Not Improve Hypoxia-Induced Erythropoiesis. High Alt Med Biol 13:269-274, 2012.-Hypoxia induces reactive oxygen species production. Supplements with antioxidant mixtures can compensate for the decline in red cell membrane stability following intermittent hypobaric hypoxia by decreasing protein and lipid oxidation. We aimed to determine whether supplementation with vitamin C is implicated in the regulation of erythropoiesis and in the oxygen-carrying capacity of the blood, and also whether antioxidant supplementation prevents the oxidative stress associated to intermittent hypoxia. Twentyfour male Wistar rats were randomly divided into four experimental groups: normoxia control (n = 6), normoxia + vitamin C (n = 6), hypoxia control (12 h pO 2 12%/12 h pO 2 21%) (n = 6), and hypoxia + vitamin C (n = 6). Animals were supplemented with vitamin C at a dose of 250 mg$kg -1 $day -1 for 21 days. Red blood cell count, hemoglobin, hematocrit, reticulocytes, erythropoietin, and oxidative stress parameters such as malondialdehyde and protein oxidation in plasma were analyzed at two different time points: basal sample (day zero) and final sample (day 21). Similar RBC, Hb, Hct, and Epo increments were observed in both hypoxic groups regardless of the vitamin C supplementation. There was no change on MDA levels after intermittent hypoxic exposure in any experimental group. However, we found an increase in plasma protein oxidation in both hypoxic groups. Vitamin C does not affect erythropoiesis and protein oxidation in rats submitted to intermittent hypoxic exposure.

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Section: Vitamin C and Erythropoiesismentioning

confidence: 65%

“…C participates in the HIF-1a (hypoxia inducible factor) hydroxylation process (Li et al, 2010). HIF-1a is a transcription factor that respond to changes in available oxygen in the cellular environment, specifically, to decreases in oxygen, or hypoxia.…”

Section: Vitamin C and Erythropoiesismentioning

confidence: 99%

Vitamin C Supplementation Does not Improve Hypoxia-Induced Erythropoiesis

Martínez-Bello

Sanchís-Gomar

Martinez‐Bello

et al. 2012

High Altitude Medicine & Biology

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“…Emerging evidence supports a role for HIF in regulating systemic responses to hypoxia across the principal organ systems responsible for oxygen delivery to cells, encompassing erythropoiesis as well as pulmonary, cardiac, and vascular functions [33]. HIF-1alpha was noticeably induced by testosterone in prostate cells [34] and this association could also be observed during exposure to hypoxia at HA.…”

Section: Discussionmentioning

confidence: 93%

High serum zinc and serum testosterone levels were associated with excessive erythrocytosis in men at high altitudes

et al. 2011

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Chronic mountain sickness (CMS), a lack of adaptation to altitude characterized by excessive erythrocytosis (EE), is a health problem associated with life at high altitude. The erythropoietic process is regulated by both erythropoietin and testosterone. Zinc (Zn) is known to be related with testosterone and hemoglobin levels; meanwhile, nitric oxide was also associated with adaptation to high altitude. The aim of this study was to determine the relationship of hemoglobin and CMS score with serum levels of zinc, total testosterone (TT), calculated free testosterone (cFT), bioavailable testosterone (BAT), hemoglobin, and nitric oxide in men at high altitude with or without EE. Men residing in Lima (150 m) and Cerro de Pasco (4,340 m), Peru, were divided into three groups: (1) low altitude, (2) high altitude without EE (hemoglobin < 21 g/dl), and (3) high altitude with EE (hemoglobin ≥ 21 g/dl). Adjusted multivariable regression models showed that serum testosterone (total or free) and Zn levels were independently correlated with increased hemoglobin levels. Similarly, hemoglobin was positively related with signs/symptoms of CMS; however, both increased the serum Zn and the nitric oxide levels correlated with reduced risk for signs/symptoms of CMS. In conclusion, higher serum testosterone levels and Zn levels were associated with EE, and low scores of signs/symptoms of CMS were associated with higher Zn and nitric oxide levels.

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“…Regarding the possible mechanisms that could have lead to the observed results, it has been reported that a VC treatment reduced the hypoxia-inducible factor 1α (HIF-1α) expression in rat prostate 50 , factor which is known to induce apelin gene expression 51 .…”

Section: Discussionmentioning

confidence: 99%

Fat intake leads to differential response of rat adipocytes to glucose, insulin and ascorbic acid

García-Díaz

Campión

Arellano

et al. 2012

Exp Biol Med (Maywood)

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Antioxidant-based treatments have emerged as novel and interesting approaches to counteract fat accumulation in obesity and associated metabolic disturbances. Adipocytes from rats that were fed on chow or high-fat diet (HFD) for 50 d were isolated (primary adipocytes) and incubated (72 h) on low (LG; 5.6 mmol/L) or high (HG; 25 mmol/L) glucose levels, in the presence or absence of 1.6 nmol/L insulin and 200 μmol/L vitamin C (VC). Adipocytes from HFD-fed animals presented lower insulin-induced glucose uptake, lower lactate and glycerol release, and lower insulin-induced secretion of some adipokines as compared with controls. HG treatment restored the blunted response to insulin regarding apelin secretion in adipocytes from HFD-fed rats. VC treatment inhibited the levels of nearly all variables, irrespective of the adipocytes’ dietary origin. The HG treatment reduced adipocyte viability, and VC protected from this toxic effect, although more drastically in control adipocytes. Summing up, in vivo chow or HFD intake determines a differential response to insulin and glucose treatments that appears to be dependent on the insulin-resistance status of the adipocytes, while VC modifies some responses from adipocytes independently of the previous dietary intake of the animals.

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Vitamin C supplementation prevents testosterone-induced hyperplasia of rat prostate by down-regulating HIF-1α

Cited by 26 publications

References 28 publications

Vitamin C Supplementation Does not Improve Hypoxia-Induced Erythropoiesis

Vitamin C Supplementation Does not Improve Hypoxia-Induced Erythropoiesis

High serum zinc and serum testosterone levels were associated with excessive erythrocytosis in men at high altitudes

Fat intake leads to differential response of rat adipocytes to glucose, insulin and ascorbic acid

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