Vitamin C Supplement Use and Bone Mineral Density in Postmenopausal Women

Morton, Deborah J.; Barrett‐Connor, Elizabeth; Schneider, Diane L.

doi:10.1359/jbmr.2001.16.1.135

Cited by 149 publications

(103 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus fibrils or/and the structure may disintegrate rapidly. Our findings were also supported by Simon et al [21], and Morton et al [22]. Table 1 shows that after therapy, no significant change occurred in vitamin C level in PMO.…”

Section: Resultssupporting

confidence: 90%

Effect of Antiresorptive Therapy on Urinary Hydroxyproline in Postmenopausal Osteoporosis

Jagtap

Ganu

2011

Ind J Clin Biochem

View full text Add to dashboard Cite

Osteoporosis becomes a serious health threat for older postmenopausal women by predisposing them to an increased risk of fracture. Osteoporosis and associated fractures are an important cause of morbidity and mortality. Special attention is being paid to early detection, management, and treatment of postmenopausal osteoporosis in women. Biochemical markers can enable dynamic and rapid measurement of total body skeletal metabolism and will be clinically useful in the management of postmenopausal osteoporosis women (PMO) and also for assessing the effects of antiresorptive therapy. With this view, we planned to assess osteoclastic activity by determining urinary hydroxyproline in osteoporotic women. The aim of this study is to measure urinary hydroxyproline (expressed as mg of hydroxyproline/g of creatinine) and serum ascorbic acid in postmenopausal women with osteoporosis and without osteoporosis. These biochemical parameters were determined 3 months post antiresorptive therapy (alendronate ? calcium ? vitamin D) in postmenopausal osteoporosis patients. 60 postmenopausal women with osteoporosis in the age group 45-60 years and 60 healthy postmenopausal women (normal bone mineral density) in the same age group were included in the study. Urinary hydroxyproline levels were significantly increased (P \ 0.001) in PMO at baseline level as compared to control group. These levels were decreased significantly (P \ 0.001) post therapy in PMO patients. Serum vitamin C levels were significantly decreased (P \ 0.001) in PMO patients at baseline level as compared to controls. No significant change occurred of serum vitamin C level post therapy. Raised excretion of hydroxyproline at the baseline level might be due to increased degradation of collagen type I from the bone matrix in osteoporosis. Breakdown of collagen seems to be lowered as reflected by lowering of hydroxyproline excretion post antiresorptive therapy. Alteration in the concentration of this marker can be very well utilized to monitor the effectiveness of therapy. Thus simple, direct urinary assay to measure bone resorption is very useful in monitoring the therapy in PMO and may become an integral part of the management of osteoporosis.

show abstract

Section: Resultssupporting

confidence: 90%

Effect of Antiresorptive Therapy on Urinary Hydroxyproline in Postmenopausal Osteoporosis

Jagtap

Ganu

2011

Ind J Clin Biochem

View full text Add to dashboard Cite

show abstract

“…Vitamin C is required for collagen crosslinking (Combs, 1998) and along with other antioxidant vitamins may serve to protect the skeleton from oxidative stress, especially from smoking (Melhus et al, 1999). Two recent population-based studies showed that use of long-term vitamin C supplements was beneficial for BMD in various skeletal sites (Leveille et al, 1997) and the effect was augmented by estrogen and Ca supplements use (Morton et al, 2001) in postmenopausal women. In our study, the stronger influence was seen with the vitamin C from food only than total (food and supplement), probably because the supplemental intake is not regular and/or of longer duration.…”

Section: Multiple Regression Resultsmentioning

confidence: 99%

Bone and nutrition in elderly women: protein, energy, and calcium as main determinants of bone mineral density

2003

View full text Add to dashboard Cite

Objective: Nutrition is an important factor in the prevention and treatment of osteoporosis. Our goal was to examine the relationship between various nutrients and bone mass of several skeletal sites in elderly women, taking into account possible confounding variables. Design/methods: A cross-sectional study in 136 healthy Caucasian, postmenopausal women, free of medications known to affect bone was carried out. Bone mineral density (BMD) and body composition (lean and fat tissue) were measured by dual X-ray absorptiometry using specialized software for different skeletal sites. Parathyroid hormone (PTH) and vitamin D, 25(OH)D, as possible confounders, were determined in serum samples. Dietary intake, including all supplements, was assessed by 3-day dietary record and analyzed using Food Processor 1 . Past physical activity and present walking were examined as well and accounted for as potential confounders. Simple and multiple regression models were created to assess the relationships between nutrients and BMD. To examine the co-linear variables and their possible independent association with bone, subgroup analyses were performed. Results: Showed independent influence of calcium, energy, and protein, examined separately and in multiple regression models on BMD of several skeletal sites. Magnesium, zinc and vitamin C were significantly related to BMD of several skeletal sites in multiple regression models (controlled for age, fat and lean tissue, physical activity and energy intake), each contributing more than 1% of variance. Serum PTH and 25(OH)D did not show significant association with bone mass. Conclusions: Despite the cross-sectional nature of our study we were able to show a significant relationship between BMD and several critical nutrients: energy, protein, calcium, magnesium, zinc and vitamin C. The exact involvement of these nutrients and their clinical significance in bone health need to be further elucidated in humans and conclusions about the effects of a single nutrient on bone mass must be given cautiously, taking into account its interaction and co-linearity with others. Understanding relationships among nutrients, not just limited to calcium and vitamin D, but others that have not been investigated to such extent, is an important step toward identifying preventive measures for bone loss and prevention of osteoporosis.

show abstract

“…Moreover, some literature documents that the above alkaline-forming cations have an independent impact on improving Ca balance (31,32) and bone health (5,6,33) . The second aspect is that vegetables and fruit might affect bone health via the roles of antioxidant vitamins, such as vitamin C (34,35) and vitamin K (36,37) . However, after adjusting for the potential influence of these nutrients, vitamin D and fibre, McGartland et al (24) proved that the positive association between fruit intake and heel BMD in the 12-year-old girls remained.…”

Section: Discussionmentioning

confidence: 99%

Fruit and vegetable intake and bone mass in Chinese adolescents, young and postmenopausal women

Huang

Wang

et al. 2012

Public Health Nutr.

View full text Add to dashboard Cite

Objective: Previous studies showed an inconsistent association of fruit and vegetable consumption with bone health. We assessed the associations in Chinese adolescents, young and postmenopausal women. Design: A cross-sectional study conducted in China during July 2009 to May 2010. Setting: Bone mineral density (BMD) and content (BMC) at the whole body, lumbar spine and left hip were measured with dual-energy X-ray absorptiometry. Dietary intakes were assessed using an FFQ. All these values were separately standardized into Z-scores in each population subgroup. Subjects: One hundred and ten boys and 112 girls (11-14 years), 371 young women (20-34 years, postpartum within 2 weeks) and 333 postmenopausal women (50-70 years). Results: After adjustment for potential covariates, analysis of covariance showed a significantly positive association between fruit intake and BMD and BMC in all participants combined (P-trend: , 0?001 to 0?002). BMD Z-score increased by 0?25 (or 2?1 % of the mean), 0?22 (3?5 %), 0?23 (3?0 %) and 0?25 (3?5 %), and BMC Z-score increased by 0?33 (5?7 %), 0?25 (5?8 %), 0?34 (5?9 %) and 0?29 (4?7 %), at the total body, lumbar spine, total hip and femoral neck in participants belonging to the top tertile compared with the bottom tertile of fruit intake (all P , 0?05), respectively. There was no significant association between vegetable intake and bone mass at all bone sites studied except for total body BMD (P 5 0?030). Relatively more pronounced effects were observed in boys and postmenopausal women. Conclusion: Our findings add to the existing evidence that fruits and vegetables may have a bone sparing effect.

show abstract

Vitamin C Supplement Use and Bone Mineral Density in Postmenopausal Women

Cited by 149 publications

References 17 publications

Effect of Antiresorptive Therapy on Urinary Hydroxyproline in Postmenopausal Osteoporosis

Effect of Antiresorptive Therapy on Urinary Hydroxyproline in Postmenopausal Osteoporosis

Bone and nutrition in elderly women: protein, energy, and calcium as main determinants of bone mineral density

Fruit and vegetable intake and bone mass in Chinese adolescents, young and postmenopausal women

Contact Info

Product

Resources

About