Vitamin C Status in People with Types 1 and 2 Diabetes Mellitus and Varying Degrees of Renal Dysfunction: Relationship to Body Weight

Carr, Anitra C.; Spencer, Emma; Heenan, Helen; Lunt, Helen; Vollebregt, M. J.; Prickett, Timothy C. R.

doi:10.3390/antiox11020245

Cited by 17 publications

(9 citation statements)

References 46 publications

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“…The status of vitamin C is controlled by renal secretion and reabsorption in the renal tubules, and patients with DN have reduced vitamin C levels due to increased vitamin C clearance. Thus, low serum blood vitamin C concentration has been shown to affect macroalbuminuria, renal dysfunction (serum creatinine, estimated glomerular filtration rate), and blood pressure [20]. However, in this study, daily vitamin C intake and MAU were not statistically significant.…”

Section: Resultscontrasting

confidence: 75%

A Cross-Sectional Study on the Microalbuminuria, glycated hemoglobin, and Vitamin C Intake of Patients with Type 2 Diabetes Mellitus

Kang¹,

Bae²,

Hur³

2023

APJCRI

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Diabetic nephropathy (DN) is a major complication occurring in type 2 diabetic(T2DM) patients and characterized by persistent albuminuria and decreased renal function. Microalbuminuria (MAU) is a well-known early marker of DN in T2DM patients. This study aimed to analyse the possible associations among glycated hemoglobin (HbA1c), daily vitamin C(ascorbic acid) intake, and urinary microalbumin, as predictors of DN in T2DM patients. The cross-sectional study was utilized to analyze the secondary data from the National Health and Nutrition Examination Survey. The study population comprised 510 patients who were not diagnosed with hypertension prior to T2DM. Statistical analysis was done by using R 3.5.1 version and this study analyzed by simple linear and stepwise multiple regression. Among patients with T2DM, 19.0% had MAU, 75.7% had nomoalbuminuria, and 5.3% had macroalbuminuria. The value of HbA1c was significantly higher in patients with MAU and macroalbuminuria than in normoalbuminuria. As a result of the study, microalbuminuria was predicted by HbA1c and there was an interaction between daily vitamin C intake and HbA1c. This means that microalbuminuria is a risk marker for DN and is associated with HbA1c and vitamin C. Therefore, in type 2 diabetic patients, periodic screening of blood glucose and high-dose vitamin C intake are required for preventing MAU and DN.

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Section: Resultscontrasting

confidence: 75%

A Cross-Sectional Study on the Microalbuminuria, glycated hemoglobin, and Vitamin C Intake of Patients with Type 2 Diabetes Mellitus

Kang¹,

Bae²,

Hur³

2023

APJCRI

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“…Our understanding of GDM pathogenesis remains incomplete, and although we have indications that oxidative stress and inflammation may play a significant role, there are likely other contributing factors. [34] Uncovering these issues can pave the way for more targeted and effective preventive strategies. The findings of this study underscore the importance of conducting further research, particularly RCTs, which are considered the gold standard in healthcare research.…”

Section: Discussionmentioning

confidence: 99%

A comprehensive meta-analysis on the association between vitamin C intake and gestational diabetes mellitus: Insights and novel perspectives

2023

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Background: Gestational Diabetes Mellitus (GDM) is a significant health concern in pregnant women and their offspring. Although Vitamin C is known to play a role in maintaining normal physiological processes, its relationship with GDM has not been fully elucidated. Methods: We conducted a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, analyzing data from 15 studies selected from PubMed, Embase, Web of Science, and the Cochrane Library up to May 16, 2023. These studies were selected based on inclusion criteria such as study design, outcome of interest, exposure factor, and data extractability. Quality assessment was performed using the Newcastle-Ottawa Scale. We assessed the heterogeneity between studies and conducted a sensitivity analysis. Results: Data from 10,131 subjects, including 1304 diagnosed GDM cases, were analyzed. The meta-analysis showed that women in the low Vitamin C exposure group had higher odds of developing GDM (odds ratio 2.72, 95% CI:1.24–4.19). There was a greater likelihood of increased GDM risk with lower Vitamin C exposure (standardized mean difference: −0.71, 95% CI [−1.07 −0.36]). Subgroup analysis revealed that both internal and external Vitamin C exposure, along with exposure during the second or third trimester of pregnancy, was associated with higher GDM incidence rates under low Vitamin C exposure. Sensitivity analysis confirmed the robustness of the results, and no significant publication bias was detected. Conclusion: Low Vitamin C exposure during pregnancy may increase the risk of GDM. Given these findings, it could be beneficial for pregnant women to increase their intake of Vitamin C-rich foods and to ensure adequate blood Vitamin C levels as a preventive measure against GDM.

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“…Plasma vitamin C concentrations ranged from 19 to 63 µM among participants, and marginal vitamin C status (<28 µM; ref. (20)) was noted for 29% of participants with T2D and 25% of participants without T2D (p = 0.825). The mean plasma concentrations did not differ between participant groups (36.0 ± 12.2 and 34.8 ± 10.9 µmol for participants with and without T2D, respectively; Table 1).…”

Section: General Characteristics Of the Participantsmentioning

confidence: 95%

Erythrocyte osmotic fragility is not linked to vitamin C nutriture in adults with well-controlled type 2 diabetes

2022

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Erythrocyte fragility is amplified by oxidative stress and linked to diabetes-specific microvascular disease. Vitamin C supplementation improves glycemic indices in adults with type 2 diabetes (T2D) by improving antioxidant status. This cross-sectional study examined the relationships between vitamin C status and erythrocyte osmotic fragility in adults with or without T2D. Participants provided a fasting blood sample for erythrocyte osmotic fragility testing as a function of hypotonic NaCl concentrations. Additionally, plasma was stabilized with metaphosphoric acid prior to vitamin C analysis using isocratic reverse-phase UV-HPLC separation. Participants were grouped as diagnosed T2D (n = 14; 36% female; 55.5 ± 8.2 y; 31.5 ± 9.0 kg/m2; HbA1c: 7.4 ± 1.9%; plasma vitamin C: 36.0 ± 12.2 μM) or no diabetes (n = 16; 69% female; 38.7 ± 13.5 y; 26.8 ± 6.6 kg/m2; HbA1c: 5.4 ± 0.3%; plasma vitamin C: 34.8 ± 10.9 μM). Participant characteristics differed between groups only for age and hemoglobin A1c (HbA1c; p < 0.05). All hemolysis parameters were in normal ranges for the participants with T2D, and no significant differences in hemolysis parameters were noted between those with or without T2D. However, among participants with T2D, the NaCl concentration eliciting 50% hemolysis was higher for those with low (<7%) vs. high (>7%) HbA1c values (p = 0.037) indicating a slightly higher erythrocyte fragility in the former group. Vitamin C status did not impact any of the hemolysis parameters in adults with or without T2D. Thus, erythrocyte fragility was not elevated in T2D, and vitamin C nutriture was not related to erythrocyte fragility in adults with well-controlled T2D.

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Vitamin C Status in People with Types 1 and 2 Diabetes Mellitus and Varying Degrees of Renal Dysfunction: Relationship to Body Weight

Cited by 17 publications

References 46 publications

A Cross-Sectional Study on the Microalbuminuria, glycated hemoglobin, and Vitamin C Intake of Patients with Type 2 Diabetes Mellitus

A Cross-Sectional Study on the Microalbuminuria, glycated hemoglobin, and Vitamin C Intake of Patients with Type 2 Diabetes Mellitus

A comprehensive meta-analysis on the association between vitamin C intake and gestational diabetes mellitus: Insights and novel perspectives

Erythrocyte osmotic fragility is not linked to vitamin C nutriture in adults with well-controlled type 2 diabetes

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