“…There is substantial variability in the serum ascorbic acid response to a given amount of dietary vitamin C [10] , even when controlling for known determinants of serum ascorbic acid such as age [11] , sex [12,13] , smoking [12,14] , body weight [10,15] , physical activity [16] and season [14] . Genetic variation can also explain some of the individual variability observed in serum ascorbic acid response to dietary vitamin C, with the common haptoglobin polymorphism [17,18] , and glutathione-S-transferase deletion polymorphisms [19,20] , influencing serum ascorbic acid concentrations.…”