Vitamin C reverses lead-induced deficits in hippocampal synaptic plasticity in rats

Karamian, Ruhollah; Komaki‬, Alireza; Salehi, Iraj; Tahmasebi, Lida; Komaki, Hamidreza; Shahidi, Siamak; Sarihi, Abdolrahman

doi:10.1016/j.brainresbull.2015.05.004

Cited by 49 publications

(10 citation statements)

References 106 publications

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“…Similar mechanism of toxicity has been proposed by Baranowska-Bosiacka et al (2012) for the effect of Pb-exposure on blood, Li et al (2015) for the gonadotoxic and spermiotoxic effects of lead and by Karamian et al (2015) during investigation of the neurotoxicity of lead in albino rats, all were through the generation of excessive amount of ROS and alteration of antioxidant defense systems in animals, therefore it has been suggested that Pb-induced oxidative stress contributes to the pathogenesis of lead poisoning by disrupting the pro-/antioxidant. This proposed mechanism can explain the significant alterations in the levels of erythrocyte MDA and blood GSH-Px levels which occurred in the current study and passes in agree with El-Sayed et al (2015); Roy et al (2015) In the present study, lead-exposed rats treated with D-penicillamine for 1 month showed significant drop in BLL and KLL with significant increase in ULL when compared to lead-treated rats.…”

Section: Discussionsupporting

confidence: 76%

Curative Role of D-Penicillamine versus Combined Garlic and Silymarin Extracts on Lead-Induced Nephrotoxicity and Oxidative Stress in Adult Male Albino Rats

Elkhalek

Ibrahim

2015

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Background Lead (Pb) poisoning is still an important global health problem, especially in developing countries. Lead has been extensively used for many years ago, and it will continue to be used in future. Aim of work: This study was conducted to compare the curative role of D-penicillamine versus combined garlic and silymarin extracts for treating nephrotoxicity in adult male rats exposed to Pb for 3 months. Material and methods: The study was conducted on 70 adult male albino rats divided into 7 groups each of 10 rats, where they received all chemicals by oral gavage. Groups I & II were the negative and positive control rats, respectively. Group III received 25 mg/kg/day D-penicillamine for 1 month (4 th month). Group IV received combined garlic 20 mg/kg/day+ silymarin 200 mg/kg/day for 1 month (4 th month). Group V received 20 mg/kg/day Pb acetate for 3 months. Group VI received Pb acetate for 3 months followed by D-penicillamine for another 1 month, with the previously mentioned doses. Group VII received Pb acetate for 3 months followed by combined garlic & silymarin for another 1 month, with the previously mentioned doses. At the end of the experimental period (4 months), Pb-level in blood, urine & kidney tissue, kidney function tests (blood urea and serum creatinine) and serum malondialdehyde (MDA) & glutathione peroxidase (GSH-Px) were measured. Light microscopic examination of hematoxylin and eosin stained kidney tissue was performed to detect histopathological changes. Results: Lead administration significantly elevated blood lead level (BLL), kidney lead level (KLL), urinary lead level (ULL) and malondialdehyde (MDA), while glutathione peroxidase (GSH-Px) showed significant decrease when compared with the negative control rats. In Pb treated group, histopathological examination of the kidney revealed extensive tubular damage by presence of necrotic epithelial cells, tubular degeneration, necrosis, cell swelling, mononuclear cell infiltration, and degenerated organelles. Kidney functions didn't show any significant differences among all groups. Treatment of rats by D-penicillamine or combined garlic & silymarin extracts resulted in significant decrease in Pb-levels and MDA with a significant increase in blood GSH-PX levels. Also, significant improvement of lead induced histopathological lesions in the kidneys was observed. Combined garlic and silymarin extract treatment showed more significant improvement than D-penicillamine treated Pb-administered groups, in most of the tested parameters. Conclusion: Both D-penicillamine and combined garlic & silymarin extracts can reduce lead induced nephrotoxicity and oxidative stress. Moreover, garlic & silymarin curative effect is better than that of D-penicillamine. Recommendations: Exposure of the population to lead must be controlled. Search for sensitive blood or urinary marker for early detection of kidney damage and further studies are needed to consider a combination of garlic and silymarin is effective in the treatment of lead-induced toxicities.

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Section: Discussionsupporting

confidence: 76%

Curative Role of D-Penicillamine versus Combined Garlic and Silymarin Extracts on Lead-Induced Nephrotoxicity and Oxidative Stress in Adult Male Albino Rats

Elkhalek

Ibrahim

2015

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…Determination of TOS and TAS may be an important factor in providing protection from cell damage caused by heavy metal–related oxidative stress . In this study, we found higher TOS levels and lower TAS levels in the plasma of the arsenic‐exposed rats than in the control rats.…”

Section: Discussionsupporting

confidence: 55%

Boron ameliorates arsenic‐induced DNA damage, proinflammatory cytokine gene expressions, oxidant/antioxidant status, and biochemical parameters in rats

İnce

Küçükkurt

Acaröz

et al. 2018

J Biochem & Molecular Tox

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Arsenic, an element found in nature, causes hazardous effects on living organisms. Meanwhile, natural compounds exhibit protective effects against hazardous substances. This study evaluated the effects of boron against arsenic-induced genotoxicity and altered biochemical parameters in rats. Thirty-five male Wistar albino rats were equally divided into five groups, and the experimental period lasted 30 days. One group was used as the control, and another group was treated with 100 mg/L arsenic in drinking water. The other groups were orally treated with 5, 10, and 20 mg/kg boron plus arsenic (100 mg/L via drinking water). Arsenic caused changes in biochemical parameters, total oxidant/antioxidant status, and DNA damage in mononuclear leukocytes. Moreover, it increased IFN-γ, IL-1β, TNF-α, and NFκB mRNA expression levels in rat tissue. However, boron treatment improved arsenic-induced alterations in biochemical parameters and increases in DNA damage and proinflammatory cytokine gene expressions.

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“…Previous reports have demonstrated that, under normal conditions, supplementation of CoQ10 [36, 37] or other antioxidant agents does not improve memory performance [9]. Elevated levels of reactive oxygen species are involved in numerous diseases, and they play a key role in several normal physiological processes and signaling pathways of cognitive processes [38-41]. Thus, increasing antioxidant levels and activities in physiological conditions have no beneficial effects on cognition and may even contribute to a decline in this process.…”

Section: Discussionmentioning

confidence: 99%

Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats

2018

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Diabetes mellitus can induce impairment in learning and memory. Cognitive and memory deficits are common in older adults and especially in those with diabetes. This is mainly because of hyperglycemia, oxidative stress, and vascular abnormalities. Coenzyme Q10 (CoQ10) can decrease oxidative stress, hyperglycemia, and inflammatory markers, and improve vascular function. Therefore, the aim of the present study was to investigate the possible effects of CoQ10 on cognitive function, learning, and memory in middle-aged healthy and diabetic rats. Adult middle-aged male Wistar rats (390–460 g, 12–13 months old) were divided into 6 experimental groups. Diabetes was induced by a single i.p. injection of streptozotocin (60 mg/kg). CoQ10 (20 or 120 mg/kg, orally by gavage) was administered for 45 days. The cognitive function and learning memory of rats were evaluated using novel object recognition (NOR) and passive avoidance tests. The discrimination index of the NOR test in the diabetic groups receiving CoQ10 (20 or 120 mg/kg) and the healthy group receiving CoQ10 (120 mg/kg) was significantly higher than that in the control group. In addition, the step through latency was significantly longer and the time spent in the dark compartment was significantly shorter in the diabetic groups receiving CoQ10 than in the control group. CoQ10 supplementation can improve learning and memory deficits induced by diabetes in older subjects. In addition, CoQ10 at higher doses can improve cognitive performance in older healthy subjects.

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Vitamin C reverses lead-induced deficits in hippocampal synaptic plasticity in rats

Cited by 49 publications

References 106 publications

Curative Role of D-Penicillamine versus Combined Garlic and Silymarin Extracts on Lead-Induced Nephrotoxicity and Oxidative Stress in Adult Male Albino Rats

Curative Role of D-Penicillamine versus Combined Garlic and Silymarin Extracts on Lead-Induced Nephrotoxicity and Oxidative Stress in Adult Male Albino Rats

Boron ameliorates arsenic‐induced DNA damage, proinflammatory cytokine gene expressions, oxidant/antioxidant status, and biochemical parameters in rats

Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats

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