Vitamin C requirement in surgical patients

Fukushima, Ryoji; Yamazaki, Eriko

doi:10.1097/mco.0b013e32833e05bc

Cited by 71 publications

(74 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Response to surgical trauma, manipulation of the bowel, and exposure of the bowel to room air are also associated with ROS generation [22]. Increased levels of ROS and decreased pre- and postoperative plasma vitamin C concentrations can be offset by vitamin C supplementation, which replenishes antioxidants and increases plasma vitamin C levels [23] (Table 2). …”

Section: Discussionmentioning

confidence: 99%

Effect of Intravenous High Dose Vitamin C on Postoperative Pain and Morphine Use after Laparoscopic Colectomy: A Randomized Controlled Trial

Jeon

Park

Moon

et al. 2016

Pain Research and Management

View full text Add to dashboard Cite

Background and Objective. Vitamin C has antioxidant, neuroprotective, and neuromodulating effects. Recently, it showed antinociceptive effect as a result of the antioxidant properties. Therefore, we designed this study to assess the effect of intravenous vitamin C on opiate consumption and pain in patients undergoing laparoscopic colectomy. Methods. A total of 100 patients were enrolled and allocated to receive 50 mg/kg vitamin C or placebo by intravenous infusion immediately after induction of anesthesia. Morphine consumption and scores of pain were assessed at 2, 6, and 24 h after completion of surgery. Results. There were 97 patients included in the analysis. Patients who received vitamin C had higher plasma concentrations of vitamin C at the end of surgery, significantly lower morphine consumption at the 2 h after end of surgery, and significantly lower pain scores at rest during first 24 h postoperatively. There was no significant difference between groups in side effects, fatigue score, or pain score during cough. Conclusion. This study shows high dose vitamin C infusion decreased postoperative pain during the first 24 h and reduced morphine consumption in the early postoperative period. Additional research needed to examine whether higher doses of vitamin C and longer infusion times can amplify these effects.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Intravenous High Dose Vitamin C on Postoperative Pain and Morphine Use after Laparoscopic Colectomy: A Randomized Controlled Trial

Jeon

Park

Moon

et al. 2016

Pain Research and Management

View full text Add to dashboard Cite

show abstract

“…This phenomenon is likely to be even more pronounced in hospitalized patients due to increased metabolic demands for vitamin C due to surgery, trauma, infection or other disease processes. Both surgical and infectious disease patients have significantly lower than normal vitamin C status and much higher vitamin C concentrations (0.5–3 g/day) are required for restoration to normal status [22, 23]. Similar trends are observed with patients with cancer [37].…”

Section: Introductionmentioning

confidence: 98%

“…Hospitalized patients, in general, are more likely to present with hypovitaminosis C (defined as plasma vitamin C concentrations <23 µmol/L), and a higher proportion of hospital patients exhibit deficiency compared with the general population [20, 21]. Trauma and surgery are known to significantly deplete vitamin C concentrations [22], and patients with severe infections and sepsis also have significant depletion of vitamin C [23]. Cancer patients typically have lower vitamin C status than healthy controls [30, 31], with a large proportion of them presenting with hypovitaminosis C and outright deficiency [32].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it seems likely that hospitalised patients, who are under enhanced physiological stress, often presenting with a disease burden, and being administered multiple drugs, will have enhanced requirements for vitamin C. In support of this premise, vitamin C intakes of 100–200 mg/day provide adequate to saturating plasma status in healthy individuals [36], however, much higher gram doses are required to normalize plasma vitamin C status in surgical and critically ill patients [22, 23]. Administration of vitamin C to cancer patients results in lower plasma concentrations compared with healthy controls [37], suggesting a depleted body pool.…”

Section: Introductionmentioning

confidence: 99%

“…All studies, but one [43], showed a decreased incidence of CRPS in the patients receiving vitamin C, with vitamin C doses ≥0.5 g/day being the most efficacious [44]. Previous research has indicated that surgical patients have high vitamin C requirements and supplementation with >0.5 g/day vitamin C is required to restore normal vitamin C status in these patients [22]. The results of these studies have been pooled in various combinations in a number of recent meta-analyses [48–52] and all, but one [50], concluded that the evidence indicates that daily administration of vitamin C can decrease the incidence of CRPS following distal fracture surgery.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The role of vitamin C in the treatment of pain: new insights

Carr¹,

McCall²

2017

J Transl Med

115

View full text Add to dashboard Cite

The vitamin C deficiency disease scurvy is characterised by musculoskeletal pain and recent epidemiological evidence has indicated an association between suboptimal vitamin C status and spinal pain. Furthermore, accumulating evidence indicates that vitamin C administration can exhibit analgesic properties in some clinical conditions. The prevalence of hypovitaminosis C and vitamin C deficiency is high in various patient groups, such as surgical/trauma, infectious diseases and cancer patients. A number of recent clinical studies have shown that vitamin C administration to patients with chronic regional pain syndrome decreases their symptoms. Acute herpetic and post-herpetic neuralgia is also diminished with high dose vitamin C administration. Furthermore, cancer-related pain is decreased with high dose vitamin C, contributing to enhanced patient quality of life. A number of mechanisms have been proposed for vitamin C’s analgesic properties. Herein we propose a novel analgesic mechanism for vitamin C; as a cofactor for the biosynthesis of amidated opioid peptides. It is well established that vitamin C participates in the amidation of peptides, through acting as a cofactor for peptidyl-glycine α-amidating monooxygenase, the only enzyme known to amidate the carboxy terminal residue of neuropeptides and peptide hormones. Support for our proposed mechanism comes from studies which show a decreased requirement for opioid analgesics in surgical and cancer patients administered high dose vitamin C. Overall, vitamin C appears to be a safe and effective adjunctive therapy for acute and chronic pain relief in specific patient groups.

show abstract

Parenteral Provision of Micronutrients to Adult Patients: An Expert Consensus Paper

Blaauw

Osland

Sriram

et al. 2019

J Parenter Enteral Nutr

View full text Add to dashboard Cite

Background Micronutrients, an umbrella term used to collectively describe vitamins and trace elements, are essential components of nutrition. Those requiring alternative forms of nutrition support are dependent on the prescribed nutrition regimen for their micronutrient provision. The purpose of this paper is to assist clinicians to bridge the gap between the available guidelines’ recommendations and their practical application in the provision of micronutrients via the parenteral route to adult patients. Methods Based on the available evidenced‐based literature and existing guidelines, a panel of multidisciplinary healthcare professionals with significant experience in the provision of parenteral nutrition (PN) and intravenous micronutrients developed this international consensus paper. Results The paper addresses 14 clinically relevant questions regarding the importance and use of micronutrients in various clinical conditions. Practical orientation on how micronutrients should be prescribed, administered, and monitored is provided. Conclusion Micronutrients are a critical component to nutrition provision and PN provided without them pose a considerable risk to nutrition status. Obstacles to their daily provision—including voluntary omission, partial provision, and supply issues—must be overcome to allow safe and responsible nutrition practice.

show abstract

Vitamin C requirement in surgical patients

Cited by 71 publications

References 48 publications

Effect of Intravenous High Dose Vitamin C on Postoperative Pain and Morphine Use after Laparoscopic Colectomy: A Randomized Controlled Trial

Effect of Intravenous High Dose Vitamin C on Postoperative Pain and Morphine Use after Laparoscopic Colectomy: A Randomized Controlled Trial

The role of vitamin C in the treatment of pain: new insights

Parenteral Provision of Micronutrients to Adult Patients: An Expert Consensus Paper

Contact Info

Product

Resources

About