Vitamin C reduces interleukin-6 plasma concentration: a systematic review and meta-analysis of randomized clinical trials

Gholizadeh, Mohammad; Saeedy, Said Abdul Ghafour; Abdi, Arash; Khademi, Fatemeh; Lorian, Keivan; Clark, Cain C. T.; Djafarian, Kurosh

doi:10.1016/j.nutos.2021.09.003

Cited by 6 publications

(3 citation statements)

References 54 publications

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“…IL-6 is a pro-inflammatory cytokine which is increased in the early stage of infection 70 . When evaluating inflammatory disorders with Nutrice IV scores more than 400 ng, interleukin 6 is the best marker 71 . Additionally, it has the potential to evaluate cytokine storms in a variety of sepsis conditions.…”

Section: Discussionmentioning

confidence: 99%

Influence of Vitamin A supplementation on inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials

Gholizadeh

Roodi

Abaj

et al. 2022

Sci Rep

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Vitamin A is an anti-oxidant which has been presumed to act as an anti-infective vitamin in many studies. This study aimed to evaluate the association between vitamin A supplementation and c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) levels in randomized control trials (RCTs) studies on adults. A systematic search was performed on databases including PUBMED, SCOPUS, and the Cochrane library. The studies included were considered for data extraction and subsequently assessed for effect. Weighted mean differences (WMD) and 95% confidence intervals (CIs) were evaluated. Among 13,219 articles 13 studies were included for analysis of CRP and TNF-α, as well as 9 studies included for IL-6 in quality and quantity. The pooled WMD analysis of CRP demonstrated that vitamin A supplementation significantly increased CRP concentration with (WMD: 0.84 mg/L; 95% CI 0.29–1.39, I2 = 0.96.2% and p value < 0.003). However, there was no significant correlation between vitamin A supplementation and lower plasma TNF-α (p < 0.45)). Subgroup analysis by dosage demonstrate significant association between vitamin A supplementation and IL-6 in dosage with 50,000 with (WMD: − 1.53 mg/L; 95% CI − 2.36 to − 0.71, p value < 0.00001) as well as a negative significant association was seen at 44 weeks of supplementation with 50,000 IU/day retinyl palmitate and TNF-a in chronic hepatitis B conditions with (− 0.94 (− 1.19, − 0.69) p < 0.0001). The result of this study demonstrates that supplementation of vitamin A at low and high dosages for short and long durations increases the CRP plasma concentrations on adults and vitamin A supplementation decreases the TNF-α concentrations in chronic hepatitis B on adults. Therefore, there is an inverse association between vitamin A supplementation and plasma and fecal IL-6 concentrations in many infection conditions.

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Section: Discussionmentioning

confidence: 99%

Influence of Vitamin A supplementation on inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials

Gholizadeh

Roodi

Abaj

et al. 2022

Sci Rep

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“…In addition to the modulation of pro-inflammatory cytokines, vitamin C also promoted the secretion of the immunosuppressive cytokine IL-10 by dendritic cells (DCs), which in turn inhibits the production of pro-inflammatory cytokines [ 44 ]. Likewise, vitamin C inhibited the NF-κB dependent production of IL-6, which is a cytokine known to promote inflammatory responses [ 45 ].…”

Section: Role Of Vitamin C In Th Cell Differentiationmentioning

confidence: 99%

Impact of vitamin C on the development, differentiation and functional properties of T cells

Sasidharan Nair,

Huehn

2024

EuJMI

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Vitamin C plays a multifaceted role in various biological processes and is well-known to facilitate pleiotropic activities in both innate and adaptive immune responses, where the antioxidant capacity of vitamin C is most likely highly relevant since immune responses mainly occur in reducing environments. Beyond its antioxidant properties, vitamin C can enhance the transcription potential of genes by promoting DNA demethylation through ten-eleven-translocation (Tet) methylcytosine dioxygenases, which have been recently demonstrated to be critical for the development and differentiation of T cells. In this minireview, we will provide a broader overview on the impact of vitamin C on signaling and regulatory activities in both innate and adaptive immune cells. Particularly, we will summarize recent findings on the decisive role of finely tuned vitamin C concentrations for T cell development, T helper cell differentiation, and optimal T cell-mediated immune responses.

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“…Moreover, ONS with vitamin C via peroral and intravenous routes can also reduce inteleukine-6 (IL-6) levels, improving the level of inflammation. 60 …”

Section: High-hierarchy Evidence For the Efficacy Of Immunonutrition ...mentioning

confidence: 99%

Fly Me to the Immune: Immunonutrition in Rheumatic Diseases

Grammatikopoulou

Marakis

Gkiouras

et al. 2023

MJR

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Immunonutrition is the maintenance and induction of immune homeostasis with the use of nutritional factors, the so called, immunonutrients. Immunonutrition focuses on four “Is” representing an equal number of systemic responses with regards to: a) Immunity, b) Infection, c) Inflammation and d) Injury. Although at the early stages of the development of immunonutrition, its application was focused on malnourished patients, with a latter extension in the intensive care unit setting, today we acknowledge the great importance of immunonutrients in rheumatology. In rheumatic diseases (RDs), all the “Is” representing the four aims and targets of immunonutrition are fulfilled. Impaired Immunity is the hallmark of RDs, with both innate and adaptive immunity contributing to the development and course of each disease entity, representing distinct immunoregulation abnormalities, often paired with micronutrient deficiencies. Infections are both drivers and a frequent epiphenomenon of systemic RDs. Subclinical inflammation is propagated long before the first signs or symptoms of RDs and musculoskeletal conditions (injury) are apparent in all patients with RDs, accompanied by pain, underlying connective tissue disease and the consequent reduction in the function of musculoskeletal. Herein, the role of probiotics, curcumin, vitamins, Selenium, Zinc and n-3 fatty acids as immunonutrients is discussed.

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Vitamin C reduces interleukin-6 plasma concentration: a systematic review and meta-analysis of randomized clinical trials

Cited by 6 publications

References 54 publications

Influence of Vitamin A supplementation on inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials

Influence of Vitamin A supplementation on inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials

Impact of vitamin C on the development, differentiation and functional properties of T cells

Fly Me to the Immune: Immunonutrition in Rheumatic Diseases

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