Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use

Padayatty, Sebastian J.; Sun, He; Wang, Yaohui; Riordan, Hugh D.; Hewitt, Stephen M.; Katz, Arie; Wesley, Robert; Levine, Mark

doi:10.7326/0003-4819-140-7-200404060-00010

Cited by 773 publications

(803 citation statements)

References 17 publications

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“…The peak serum level of vitamin C occurs at about four hours after administration. 23,24 In our study, the decrease in morphine consumption started post PACU discharge, approximately four hours after administration of vitamin C, which may correspond with the onset of its analgesic effect.…”

Section: Discussionmentioning

confidence: 49%

Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial

Kanazi

El-Khatib

Yazbeck‐Karam

et al. 2012

Can J Anesth/J Can Anesth

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Section: Discussionmentioning

confidence: 49%

Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial

Kanazi

El-Khatib

Yazbeck‐Karam

et al. 2012

Can J Anesth/J Can Anesth

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“…At high concentrations ascorbate is preferentially toxic to cancer cells. There is some evidence that large doses of vitamin C, either in multiple divided oral doses or intravenously, have beneficial effects in cancer therapy [154-156]. Oral doses, even in multiple divided doses, are not as effective as intravenous administration.…”

Section: Reviewmentioning

confidence: 99%

“…Oral doses, even in multiple divided doses, are not as effective as intravenous administration. Vitamin C at a dose of 1.25 g administered orally produced mean peak plasma concentrations of 135 ± 21 μmol/L compared with 885 ± 201 μmol/L for intravenous administration [154]. …”

Section: Reviewmentioning

confidence: 99%

Nutrition and cancer: A review of the evidence for an anti-cancer diet

Donaldson¹

2004

Nutr J

529

344

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It has been estimated that 30–40 percent of all cancers can be prevented by lifestyle and dietary measures alone. Obesity, nutrient sparse foods such as concentrated sugars and refined flour products that contribute to impaired glucose metabolism (which leads to diabetes), low fiber intake, consumption of red meat, and imbalance of omega 3 and omega 6 fats all contribute to excess cancer risk. Intake of flax seed, especially its lignan fraction, and abundant portions of fruits and vegetables will lower cancer risk. Allium and cruciferous vegetables are especially beneficial, with broccoli sprouts being the densest source of sulforophane. Protective elements in a cancer prevention diet include selenium, folic acid, vitamin B-12, vitamin D, chlorophyll, and antioxidants such as the carotenoids (α-carotene, β-carotene, lycopene, lutein, cryptoxanthin). Ascorbic acid has limited benefits orally, but could be very beneficial intravenously. Supplementary use of oral digestive enzymes and probiotics also has merit as anticancer dietary measures. When a diet is compiled according to the guidelines here it is likely that there would be at least a 60–70 percent decrease in breast, colorectal, and prostate cancers, and even a 40–50 percent decrease in lung cancer, along with similar reductions in cancers at other sites. Such a diet would be conducive to preventing cancer and would favor recovery from cancer as well.

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“…Plasma concentration of vitamin C are highly controlled when the vitamin is taken orally [38]. But no pharmacokinetic studies on vitamin C were conducted in saliva.…”

Section: Effect Of Vitamin Cmentioning

confidence: 99%

Salivary Markers of Oxidative Stress and Antioxidant Status: Influence of External Factors

2013

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Abstract.BACKGROUND: Salivary markers of oxidative stress and antioxidant status represent promising tool for the research of oral diseases. One of the criteria is the validation of these biomarkers from the perspective of the confounding and modifying factors. AIM: To examine the effect of circadian rhythm, tooth-brushing and ascorbic acid treatment on selected salivary markers of oxidative and carbonyl stress, and antioxidant status. SUBJECTS AND METHODS: Whole unstimulated saliva samples were collected from 19 healthy participants three times during a day, before and after tooth-brushing, and before and after the administration of vitamin C (250 mg). Advanced oxidation protein products (AOPP), thiobarbituric acid reactive substances (TBARS), advanced glycation end products (AGEs), ferric reducing antioxidant power (FRAP) and total antioxidant capacity (TAC) were measured. RESULTS: Salivary AGEs levels varied significantly during the day (p < 0.05) with the highest concentrations in the morning. FRAP levels varied during the day (p < 0.01) with the highest concentrations in the afternoon. Tooth-brushing decreased AGEs (p < 0.05) and TBARS levels (p < 0.01) and increased FRAP levels (p < 0.05). Single intake of vitamin C significantly decreased AGEs (p < 0.001) and increased both FRAP (p < 0.01) and TAC (p < 0.01) concentrations. CONCLUSION: Significant daily variations were observed in salivary AGEs and FRAP levels. Tooth-brushing and treatment with vitamin C decreased carbonyl stress and increased the antioxidant status. These results are important from the perspective of using saliva for the research of oral diseases.

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Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use

Cited by 773 publications

References 17 publications

Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial

Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial

Nutrition and cancer: A review of the evidence for an anti-cancer diet

Salivary Markers of Oxidative Stress and Antioxidant Status: Influence of External Factors

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