Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO‐1 Pathway
Shuli Man,
Jingxian Bi,
Furui Liu
et al.
Abstract:As an important nutritional component, vitamin C (Vc) shows good antitumor activity in a variety of cancer, but there are few studies in pulmonary metastasis. In order to verify its anticancer and antimetastatic effect, the study sets up H22 pulmonary metastasis mouse model. The results show that intraperitoneal injection of Vc inhibits pulmonary metastasis through up‐regulating the expression of Nrf2, HO‐1, cleaved caspases 3 and 9, and causing DNA damage and apoptosis which is similar to the pro‐oxidant effe… Show more
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