Vitamin C in Relation to Cold Temperature Tolerance*

Dugal, L. P.

doi:10.1111/j.1749-6632.1961.tb46131.x

Cited by 13 publications

(7 citation statements)

References 13 publications

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“…Studies in animals and humans have indicated that vitamin C may protect against stress caused by cold and hot environments [34,35,36,37]. Some common cold studies with positive results investigated physically active participants in cold environments and other studies investigated marathon runners in South Africa (see below).…”

Section: Biology Relevant To the Effects Of Vitamin C On Infectionsmentioning

confidence: 99%

Vitamin C and Infections

2017

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In the early literature, vitamin C deficiency was associated with pneumonia. After its identification, a number of studies investigated the effects of vitamin C on diverse infections. A total of 148 animal studies indicated that vitamin C may alleviate or prevent infections caused by bacteria, viruses, and protozoa. The most extensively studied human infection is the common cold. Vitamin C administration does not decrease the average incidence of colds in the general population, yet it halved the number of colds in physically active people. Regularly administered vitamin C has shortened the duration of colds, indicating a biological effect. However, the role of vitamin C in common cold treatment is unclear. Two controlled trials found a statistically significant dose–response, for the duration of common cold symptoms, with up to 6–8 g/day of vitamin C. Thus, the negative findings of some therapeutic common cold studies might be explained by the low doses of 3–4 g/day of vitamin C. Three controlled trials found that vitamin C prevented pneumonia. Two controlled trials found a treatment benefit of vitamin C for pneumonia patients. One controlled trial reported treatment benefits for tetanus patients. The effects of vitamin C against infections should be investigated further.

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Section: Biology Relevant To the Effects Of Vitamin C On Infectionsmentioning

confidence: 99%

Vitamin C and Infections

2017

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“…Temperature changes: Vitamin C has been reported to have beneficial effects on resistance and acclimatization to cold and hot environments [8,103]. Low temperatures weaken the immune response [8] and increase the risk of infections.…”

Section: Factors and Situations Challenging The Immune Systemmentioning

confidence: 99%

“…Studies have reported that prolonged exposure of the body surface to cold temperatures (cold baths, cold air, wet clothes, drafts, etc.) leads to a vitamin C deficit [103]. Vitamin C protects against common cold caused by heavy exercise / exercise in cold (subarctic) conditions [8].…”

Section: Factors and Situations Challenging The Immune Systemmentioning

confidence: 99%

Vitamins C, D and Zinc: Synergistic Roles in Immune Function and Infections

Maggini¹,

Maldonado²,

Cardim³

et al. 2017

Vitam Miner

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The immune system is a complex and sophisticated network of specialized tissues, organs, cells, proteins, and chemicals which has evolved in order to protect the host from a range of dangerous agents such as bacteria, virus, fungi, and parasites. There is a close relationship between nutritional status and immune function. Hence, immunocompetence can be regarded as a measure of adequate nutrition. Inter-individual variations in many immune functions exist within the normal healthy population and are due to age, genetics, gender, ethnic background, socioeconomic situation, diet, stress, habitual levels of exercise, alcohol consumption, smoking habits, etc. In addition, seasonal and temperature changes as well as being in crowded spaces (e.g., while commuting in public means of transportation, or working in open space offices) pose an additional burden on the immune system. Here we review the literature on the immune supportive properties of vitamins C, D and zinc and the impact of their supplementation in reducing the incidence or ameliorating symptoms of upper respiratory tract infections, which are among the most common infections in humans. Finally, we discuss their relevance in situations known to challenge the immune system such as exposure to temperature changes, to pollutants, or being in crowded spaces which serve as mixers where pathogens can stay suspended and transfer from host to host thereby increasing the risk of spreading infectious diseases because of close contact and long exposure.

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“…rodents) show elevated levels in various situations of stress, including cold stress. Studies on cold acclimatization have shown beneficial effects with increased concentrations in specific tissues (Dugal 1961).…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin C and E supplementation in modulating the peripheral nerve conduction following cold exposure in humans

Panjwani

Yadav

Kumar

et al. 2003

International Journal of Biometeorology

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Exposure to an extremely cold environment without proper protection leading to hypothermia is an emergency, one of the several complications of which is impairment in nerve conduction. Our previous work in the rat model has shown the beneficial effect of vitamin C in modulating the effect of hypothermia on nerve conduction. The present study aimed to evaluate the effect of vitamins C and E, administered alone or in combination, in modulating the effect of mild hypothermia on human ulnar nerve conduction. The study was carried out on 26 volunteers divided into three groups: group I received vitamin C supplementation (2000 mg/day in a single dose and 1,000 mg/day for the next 6 days), group II received vitamins C and E in combination (1,000 mg and 800 mg respectively in a single dose and 500 mg and 400 mg respectively for the next 6 days) and group III received vitamin E (800 mg in a single dose and the same for the next 6 days). The recordings were carried out before and after single and weekly supplementation in each group. There was a fall in ulnar nerve conduction velocity with a reduction in the oral temperature of 2-2.5 degrees C. Vitamin C administered alone and in combination with vitamin E reduced the fall in ulnar nerve conduction velocity. Prior supplementation with vitamin C and E could help ameliorate the impairment in human ulnar nerve conduction due to hypothermia.

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Vitamin C in Relation to Cold Temperature Tolerance*

Cited by 13 publications

References 13 publications

Vitamin C and Infections

Vitamin C and Infections

Vitamins C, D and Zinc: Synergistic Roles in Immune Function and Infections

Effect of vitamin C and E supplementation in modulating the peripheral nerve conduction following cold exposure in humans

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