Vitamin C Enhances Antiviral Functions of Lung Epithelial Cells

Teafatiller, Trevor; Agrawal, Sudhanshu; Robles, Gabriela De; Rahmatpanah, Farah; Subramanian, Veedamali S.; Agrawal, Anshu

doi:10.3390/biom11081148

Cited by 19 publications

(15 citation statements)

References 49 publications

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“…Furthermore, vitamin C therapy reduced the effects of sepsis on pulmonary dysfunction in septic mice with ARDS by down regulating proinflammatory genes and improving epithelial membrane permeability ( 124 , 125 ). A recent report revealed that, vitamin C increases the antiviral activity of lung epithelial cells and protects lung fibrosis and damage in both in vivo and in vitro models ( 131 ). Previous placebo-control trials found that high-dose vitamin C (2-16 g/day) was successful in reducing the mortality of patients with sepsis, severe influenza, and acute lung damage as well as reducing the length of stay in the intensive care unit (ICU) and the duration of mechanical ventilation ( 124 , 125 , 131 ).…”

Section: Vitamins and Food Supplements To Enhance Immunity Against Vi...mentioning

confidence: 99%

“…A recent report revealed that, vitamin C increases the antiviral activity of lung epithelial cells and protects lung fibrosis and damage in both in vivo and in vitro models ( 131 ). Previous placebo-control trials found that high-dose vitamin C (2-16 g/day) was successful in reducing the mortality of patients with sepsis, severe influenza, and acute lung damage as well as reducing the length of stay in the intensive care unit (ICU) and the duration of mechanical ventilation ( 124 , 125 , 131 ). Additionally, vitamin C may modulate the cytokine storm, which is characterized by elevated levels of the proinflammatory cytokine interleukin (IL)-6, increasing the likelihood of respiratory failure necessitating mechanical ventilation in COVID-19 patients ( 125 ).…”

Section: Vitamins and Food Supplements To Enhance Immunity Against Vi...mentioning

confidence: 99%

“…Additionally, vitamin C may modulate the cytokine storm, which is characterized by elevated levels of the proinflammatory cytokine interleukin (IL)-6, increasing the likelihood of respiratory failure necessitating mechanical ventilation in COVID-19 patients ( 125 ). As severe COVID-19 infection can lead to sepsis and ARDS, numerous studies have attempted to alleviate these symptoms with high doses of vitamin C ( 131 ). Several clinical trials have been ongoing since initial trials in China and the United States reported the beneficial effects of high-dose intravenous (IV) vitamin C, but due to the excellent safety profile of vitamin C and the need for ICU treatment for a huge percentage of COVID-19 cases, clinical application of vitamin C has been proposed by many authors, even before the outcomes of large clinical trials are available ( 119 , 124 , 131 ).…”

Section: Vitamins and Food Supplements To Enhance Immunity Against Vi...mentioning

confidence: 99%

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A Review on Measures to Rejuvenate Immune System: Natural Mode of Protection Against Coronavirus Infection

et al. 2022

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SARS-CoV-2, a novel Corona virus strain, was first detected in Wuhan, China, in December 2019. As of December 16, 2021, almost 4,822,472 people had died and over 236,132,082 were infected with this lethal viral infection. It is believed that the human immune system is thought to play a critical role in the initial phase of infection when the viruses invade the host cells. Although some effective vaccines have already been on the market, researchers and many bio-pharmaceuticals are still working hard to develop a fully functional vaccine or more effective therapeutic agent against the COVID-19. Other efforts, in addition to functional vaccines, can help strengthen the immune system to defeat the corona virus infection. Herein, we have reviewed some of those proven measures, following which a more efficient immune system can be better prepared to fight viral infection. Among these, dietary supplements like- fresh vegetables and fruits offer a plentiful of vitamins and antioxidants, enabling to build of a healthy immune system. While the pharmacologically active components of medicinal plants directly aid in fighting against viral infection, supplementary supplements combined with a healthy diet will assist to regulate the immune system and will prevent viral infection. In addition, some personal habits, like- regular physical exercise, intermittent fasting, and adequate sleep, had also been proven to aid the immune system in becoming an efficient one. Maintaining each of these will strengthen the immune system, allowing innate immunity to become a more defensive and active antagonistic mechanism against corona-virus infection. However, because dietary treatments take longer to produce beneficial effects in adaptive maturation, personalized nutrition cannot be expected to have an immediate impact on the global outbreak.

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Section: Vitamins and Food Supplements To Enhance Immunity Against Vi...mentioning

confidence: 99%

Section: Vitamins and Food Supplements To Enhance Immunity Against Vi...mentioning

confidence: 99%

Section: Vitamins and Food Supplements To Enhance Immunity Against Vi...mentioning

confidence: 99%

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A Review on Measures to Rejuvenate Immune System: Natural Mode of Protection Against Coronavirus Infection

et al. 2022

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“…Vitamin C, Vitamin E, Curcumin, Selenium [37,106,108,109] Antiviral Selenium, Curcumin, Quercetin, Riboflavin, Vitamin C, Green Tea, Propolis, Resveratrol, Zinc [99,100,103,109,110,111,112,113] Immune response Vitamin A, Vitamin C, Vitamin D, Vitamin B12, Folate, Pyridoxine, Zinc, Nicotinamide, Selenium [38,109,113] Interferon production Vitamin C [111] Virus-ACE2 interaction reduction Quercetin, Curcumin [11]…”

Section: Antioxidantmentioning

confidence: 99%

A review of natural foods consumed during the COVID-19 pandemic life

Hurcan

İrkin

2022

Postępy Higieny I Medycyny Doświadczalnej

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Coronavirus 2019 (COVID-19) is an infectious disease that has brought life to a standstill around the world. Until a vaccine was found to combat COVID-19, the world conducted research and made recommendations for nutritional natural foods. Considering the risks incurred by contracting the disease, even though the production of various vaccines and vaccination of healthy people has started in some countries, individuals need useful foods to be ready for the COVID-19 pandemic. Recently, nutrient contents such as antioxidant compounds, vitamins, minerals, and probiotics that contribute to the immune system have been investigated. This paper attempts to determine the role of these dietary supplements in reducing the risk of COVID-19 and/or changing the course of the disease in COVID-19 patients and their effects on mortality. Supplements used and recommended for the COVID-19 pandemic life were investigated. In conclusion, more research is needed to determine the effectiveness of nutrients, vitamins, minerals, probiotics, prebiotics, and antioxidants used during the COVID-19 pandemic to inhibit the effect of SARS-CoV-2. In order to overcome the new global crisis, nutritional cures and treatments should be upgraded. However, additional research on the subject is needed.

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“…Parenteral vitamin C infusion protected mice from the harmful consequences of sepsis by several mechanisms, including attenuation of the proinflammatory response, enhancement of epithelial barrier function, increasing alveolar fluid clearance, and prevention of sepsis-associated coagulation abnormalities [64]. An in-vitro study found that vitamin C acts at multiple levels to exert its antiviral and protective functions in the lungs significant upregulation of several metabolic pathways and interferon-stimulated genes (ISGs) along with a downregulation of pathways involved in lung injury and inflammation [65].…”

Section: Vitamin C Inhibits the Cytokine Storm Due To Its Antioxidant Capacitymentioning

confidence: 99%

The Effects of Vitamin C on the Multiple Pathophysiological Stages of COVID-19

Miranda-Massari

Toro

Loh³

et al. 2021

Life

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Currently available anti-viral drugs may be useful in reducing the viral load but are not providing the necessary physiological effects to reduce the SARS-CoV-2 complications efficiently. Treatments that provide better clinical outcomes are urgently needed. Vitamin C (ascorbic acid, AA) is an essential nutrient with many biological roles that have been proven to play an important part in immune function; it serves as an antioxidant, an anti-viral, and exerts anti-thrombotic effects among many other physiological benefits. Research has proven that AA at pharmacological doses can be beneficial to patients with acute respiratory distress syndrome (ARDS) and other respiratory illnesses, including sepsis. In addition, High-Dose Intravenous Vitamin C (HDIVC) has proven to be effective in patients with different viral diseases, such as influenza, chikungunya, Zika, and dengue. Moreover, HDIVC has been demonstrated to be very safe. Regarding COVID-19, vitamin C can suppress the cytokine storm, reduce thrombotic complications, and diminish alveolar and vascular damage, among other benefits. Due to these reasons, the use of HDIVC should be seriously considered in complicated COVID-19 patients. In this article, we will emphasize vitamin C’s multiple roles in the most prominent pathophysiological processes presented by the COVID-19 disease.

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Vitamin C Enhances Antiviral Functions of Lung Epithelial Cells

Cited by 19 publications

References 49 publications

A Review on Measures to Rejuvenate Immune System: Natural Mode of Protection Against Coronavirus Infection

A Review on Measures to Rejuvenate Immune System: Natural Mode of Protection Against Coronavirus Infection

A review of natural foods consumed during the COVID-19 pandemic life

The Effects of Vitamin C on the Multiple Pathophysiological Stages of COVID-19

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