Vitamin C decreases reduced glutathione in chronic haemodialysis patients: a pilot, randomised, double-blind trial

Martins, Mayara Lopes; Silva, Angela Teodósio da; Machado, Roberta Pieri; Ramos, Hanna Pillmann; Martinelli, Caroline; Silveira, Taís Thomsen; Silva, Edson Luiz da; Wazlawik, Elisabeth

doi:10.1007/s11255-021-02797-8

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…In addition, Martins et al (2021) reported a non-significant decrease in GPx levels when patients were given 0.250 g of vitamin C three times/week for 8 weeks. The discrepancy between the previously mentioned studies’ results and the current study ones might be due to their shorter length of study intervention (8 weeks) compared to ours (16 weeks), about double the study period.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the combination effect of rutin and vitamin C supplementation on the oxidative stress and inflammation in hemodialysis patients

et al. 2022

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Background: Hemodialysis (HD) patients are at risk of malnutrition, cardiovascular complications, and all-cause mortality due to oxidative stress and inflammation. Some studies have demonstrated that rutin attenuates oxidative stress and inflammation in CKD rats, but its effects in HD patients are unknown to date.Aim: The aim of this study was to evaluate the effect of rutin and vitamin C versus vitamin C alone on oxidative stress and inflammation in HD patients.Methods: A prospective randomized, open-label, controlled trial enrolled on hundred and five HD patients divided into three groups as follows: patients in group 1 were given a rutin/vitamin C combination (Ruta C group as the combination trade name is known as Ruta C 60 tablets), patients in group 2 were given vitamin C (1 g) (vitamin C group), and group 3 was the control group; the study period was 16 weeks. The following were assessed at baseline and at the end of the study: serum malondialdehyde (MDA), glutathione peroxidase (GPx), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), lipid profile levels, and erythrocyte sedimentation rate.Results: It was found that vitamin C significantly increased serum GPx in group 2 (p = 0.001) compared to a non-significant result in both group 1 and 3; in addition, serum MDA and TNF-α values had decreased significantly in the three groups compared to their baselines; however, a non-significant difference was seen among the studied groups at the end of the study. On the other hand, MDA levels were reduced by 50% in interventional groups compared to 28% in the control group, while the Ruta C group showed an 80% reduction in the level of TNF α compared to the 78% reduction observed in the vitamin C group, and finally, the interventional drugs showed a significant improvement in the lipid profile.Conclusion: Vitamin C supplementation alone for 16 weeks had a potential effect on the antioxidant’s GPx activity. Moreover, it was reported that both vitamin C alone or the rutin/vitamin C combination (Ruta C) showed a protective role against lipid peroxidation, evidenced by the reduced levels of MDA. Finally, rutin had a favorable synergistic effect with vitamin C in reducing TG and TNF-α levels and increasing HDL-C level.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the combination effect of rutin and vitamin C supplementation on the oxidative stress and inflammation in hemodialysis patients

et al. 2022

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Section: Discussionmentioning

confidence: 99%

“…Therefore, it can be used as an important indicator of OS in the body, and the amount generated is proportional to the degree of peroxidation, which can reflect the degree of cell damage. GSH-Px is an important enzyme that is widely present in the body and catalyzes the breakdown of hydrogen peroxide; the direct antioxidant action of GSH is guided by the activity of GSH-Px [ 19 ]. It specifically catalyzes the reduction of hydrogen peroxide with reduced GSH, which can have a role in protecting the structural and functional integrity of cell membranes, and it is an important factor involved in the repair of damaged DNA during DNA synthesis [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of the effect of perineural dexmedetomidine on oxidative stress during peritoneal dialysis catheter insertion: a randomized, controlled trial

et al. 2022

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Purpose This study aimed to evaluate the effect of the addition of dexmedetomidine to ropivacaine on oxidative stress during transversus abdominis plane (TAP) and rectus sheath (RS) blockades for patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis (PD) catheter insertion. Methods Sixty patients with ESRD undergoing PD catheter insertion to receive left ultrasound-guided TAP and RS blockades were randomly divided into two groups: the dexmedetomidine plus ropivacaine group (25 mL of 0.3% ropivacaine + 1 μg/kg dexmedetomidine) and the ropivacaine group (25 mL of 0.3% ropivacaine). Primary outcomes were oxidative stress marker levels during the procedure. Results A total of 60 patients (30 patients in each group) were evaluated. Compared with the ropivacaine group, the dexmedetomidine plus ropivacaine group had significantly lower serum malondialdehyde levels (P < 0.05) and increased glutathione peroxidase (P < 0.01) and superoxide dismutase levels at 24 h after the procedure (P < 0.01). Conclusion The addition of 1 μg/kg of dexmedetomidine to ropivacaine for ultrasound-guided TAP and RS blockades could inhibit oxidative stress in patients with ESRD undergoing PD catheter insertion. Trial registration This study was registered at www.chictr.org.cn on June 7, 2021 (ChiCTR2100047050).

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“…The GSH and CD36 expression level in plasma of IA and healthy control were measured by using enzymelinked immunosorbent assay (ELISA) as described previously [24,25]. In the measurement of GSH and CD36 a pool of EDTA plasma was aliquoted, analyzed at seven different dilutions, and used as a standard concentration curve.…”

Section: Measurement Of Cd36 and Gshmentioning

confidence: 99%

Evaluation of plasma CD36 and glutathione as potential biomarkers for intracranial aneurysm.

Wang

Liu

et al. 2023

Preprint

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The underlying mechanisms of intracranial aneurysm (IA) formation and rupture are still unclear. Evidence has proved that it might be closely related to inflammatory response and oxidative stress. Our objective was to identify novel inflammatory and oxidative stress related biomarkers to assist IA management. In this study, the enzyme-linked immunosorbent assay was performed to measure the expression levels of CD36 and glutathione (GSH) in the plasma of 30 IA patients and 30 healthy controls. Then, correlation analysis and receiver operating characteristic (ROC) curve, and logistic regression analysis were applied to investigate CD36 and GSH as potential biomarker for IA. The expression level of plasma CD36 in the IA patients was significantly higher than that in the control group (P < 0.0001), and the level of plasma GSH in the IA patients was significantly lower than that in the control group (P < 0.0001). The plasma level of CD36 and GSH did not show significant correlation with age, Glasgow Coma Scale (GCS), Hunter-Hess score, aneurysm size, aneurysm height, aneurysm neck, and aspect ratio. ROC analysis showed that CD36 and GSH had high sensitivity (90.0%, 96.6%) and specificity (96.6%, 86.6%) for IA diagnosis. And the combined sensitivity and specificity achieved 100% and 100%, respectively. The AUC of logistic regression model based on CD36 and GSH was 0.505. Our results suggested that CD36 and GSH might participate in the process of IA formation and rupture but did not affect its morphology. Moreover, the combination plasma CD36 and GSH could serve as potential biomarker for IA rupture.

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Vitamin C decreases reduced glutathione in chronic haemodialysis patients: a pilot, randomised, double-blind trial

Cited by 8 publications

References 39 publications

Evaluation of the combination effect of rutin and vitamin C supplementation on the oxidative stress and inflammation in hemodialysis patients

Evaluation of the combination effect of rutin and vitamin C supplementation on the oxidative stress and inflammation in hemodialysis patients

Assessment of the effect of perineural dexmedetomidine on oxidative stress during peritoneal dialysis catheter insertion: a randomized, controlled trial

Evaluation of plasma CD36 and glutathione as potential biomarkers for intracranial aneurysm.

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