Vitamin C and COVID-19

Abstract

In numerous animal studies, vitamin C has prevented and alleviated viral and bacterial infections. In a few dozen placebo-controlled trials with humans, vitamin C has shortened infections caused by respiratory viruses, which indicates that the vitamin can also influence viral infections in humans. In critically ill patients, plasma vitamin C levels are commonly very low. Gram doses of vitamin C are needed to increase the plasma vitamin C levels of critically ill patients to the levels of ordinary healthy people. A meta-analysis of 12 trials with 1,766 patients calculated that vitamin C reduced the length of ICU stay on average by 8%. Another meta-analysis found that vitamin C shortened the duration of mechanical ventilation in ICU patients. Two randomized placebo-controlled trials found statistically significant reduction in the mortality of sepsis patients. The effects of vitamin C on acute respiratory distress syndrome (ARDS) frequently complicating COVID-19 pneumonia should be considered. Vitamin C is a safe and inexpensive essential nutrient.

Vitamin C May Increase the Recovery Rate of Outpatient Cases of SARS-CoV-2 Infection by 70%: Reanalysis of the COVID A to Z Randomized Clinical Trial

“…The respiratory viruses covered in many trials of vitamin C are non-specific and so it is unlikely that the benefits of vitamin C are constrained to a particular respiratory virus or virus group. Thus, it seems likely that vitamin C may also have an effect on the SARS-CoV-2 coronavirus (11,24).…”

Vitamin C may increase the recovery rate of outpatient cases of SARS-CoV-2 infection by 70%: reanalysis of the COVID A to Z Randomized Clinical Trial

“…The respiratory viruses covered in many trials of vitamin C are non-speci c and so it is unlikely that the bene ts of vitamin C are constrained to a particular respiratory virus or virus group. Thus, it seems likely that vitamin C may also have an effect on the SARS-CoV-2 coronavirus [11,24].…”

Evaluation of stool and urine parameters correlation to CRP and D-dimer in COVID-19 infected adults and their contact children

“…The urine SG of our adult cases was significantly higher than cohort contact children. Although there is as yet no direct evidence indicating that vitamin C is beneficial specifically against COVID-19, but many authors [29] suggested benefits of vitamin C intake and that it should be considered for patients. The prevalence of this concept led to an increase in the intake of vitamin C among patients in exaggerated quantities.…”