Vitamin C alleviates hyperuricemia nephropathy by reducing inflammation and fibrosis

Li, Hongling; Liu, Xuejiao; Lee, Mee-Hyun; Li, Haitao

doi:10.1111/1750-3841.15803

Cited by 29 publications

(14 citation statements)

References 47 publications

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“…It is known that XO can also directly oxidize ascorbate [ 27 ]; however, ascorbate supplementation significantly protects the organism against XO hyperactivity [ 28 ]. Moreover, the latest studies show that due to the possibility of continuous supplementation with ascorbate, the resulting inhibition of XO activity in plasma significantly contributes to the improvement in gout treatment [ 29 , 30 , 31 , 32 ]. On the other hand, ascorbate has no effect on the activity of XO under physiological conditions, as found with skin cells (fibroblasts and keratinocytes).…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

“…However, in cells under stress caused by, e.g., UV radiation or hydrogen peroxide, treatment with ascorbate (100 µM) inhibited XO hyperactivation [ 33 , 34 ]. Moreover, such decrease in XO activity induced by ascorbate may be useful in preventing or reducing reperfusion injuries also in stimulated neutrophils (6 µM of ascorbate) [ 35 ] and delay the progression of hyperuricemic nephropathy (10 mg/kg/day of ascorbate) [ 32 ].…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

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Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid

2022

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Ascorbic acid, as a one of the basic exogenous vitamins, occurs in the body in the form of ascorbate, known for its strong antioxidant and anti-inflammatory properties. The presented review shows not only the importance of ascorbate as a free radical scavenger but also summarizes its antioxidant action based on other mechanisms, including the activation of intracellular antioxidant systems and its effect on the NFκB/TNFα pathway and apoptosis. Ascorbate interacts with small-molecule antioxidants, including tocopherol, glutathione, and thioredoxin; it can also stimulate biosynthesis and the activation of antioxidant enzymes, such as superoxide dismutase, catalase, or glutathione peroxidase. Moreover, ascorbate promotes the activity of transcription factors (Nrf2, Ref-1, AP-1), which enables the expression of genes encoding antioxidant proteins. Additionally, it supports the action of other exogenous antioxidants, mainly polyphenols. In this regard, both DNA, proteins, and lipids are protected against oxidation, leading to an inflammatory reaction and even cell death. Although ascorbate has strong antioxidant properties, it can also have pro-oxidant effects in the presence of free transition metals. However, its role in the prevention of DNA mutation, inflammation, and cell apoptosis, especially in relation to cancer cells, is controversial.

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Section: Antioxidant Propertiesmentioning

confidence: 99%

Section: Antioxidant Propertiesmentioning

confidence: 99%

Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid

2022

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“…Because of its proinfammatory characteristics, hyperuricemia may have an important role in the pathogenesis of cancer. Its mechanism may be related to reactive oxygen species (ROS), infammatory corpuscle activation, and xanthine oxidoreductase (XO) mediated production of active free radicals [11][12][13][14][15]. It is closely related to the incidence, mortality, and prognosis of many solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia

Guo

Jiang

Quan

et al. 2022

Journal of Oncology

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Background. Hepatocellular carcinoma (HCC) is a kind of primary liver cancer that accounts for more than 90% of primary hepatocellular carcinomas. Hyperuricemia is closely related to the development, recurrence, metastasis, and prognosis of cancer. Previous studies have proved that the serum uric acid level can increase the incidence rate and mortality of malignant tumors. However, the specific pathogenesis remains unstudied. Methods. RT-qPCR analysis showed that the mRNA expression of PDZK1 and ABCG2 increased significantly after HCC cells were exposed to different concentrations of soluble uric acid (2.5, 5, 10, 20 mg/dl) for 24 hours. Then, in HCC shRNAs, PDZK1, or over expression PDZK1 were used. CCK8, wound healing, and Transwell assay showed that PDZK1 regulates cell proliferation, invasion, and migration. Flow cytometry results revealed that PDZK1 affects cell apoptosis. Western blot results show that PDZK1 affects the STAT3/C-myc pathway. Then, in vivo tumorigenesis, allopurinol maybe an effective drug to advance: the prognosis of HCC. Results. In our study, RT-qPCR analysis showed that the mRNA expression of PDZK1 and ABCG2 increased significantly after different concentrations of soluble uric acid in HCC. Then, PDZK1 affects the proliferation, migration, and apoptosis of HCC through the STAT3/C-myc pathway. Conclusions. Hyperuricemia response affects the expression of PDZK1; PDZK1 affects the proliferation, migration, and apoptosis through the STAT3/C-myc pathway in hepatocellular carcinoma. It is suggested that PDZK1 maybe closely related to the occurrence, development, and prognosis of HCC and allopurinol maybe have potential anticancer effects.

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“…Kidney injury, as the main cause of uric acid excretion disorder, is linked to pro-inflammatory cytokines and markers of inflammation [12]. Some nutrients can also alleviate hyperuricemia nephropathy by reducing the level of inflammation [13].…”

Section: Introductionmentioning

confidence: 99%

Dietary Inflammatory Index and the Risk of Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents

et al. 2021

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Background: Dietary Inflammatory Index (DII) scores have been consistently associated with several chronic diseases. This study explored the correlation between the DII and hyperuricemia in Chinese adult residents. Methods: The study included 7880 participants from the China Health and Nutrition Survey (CHNS), which was taken in in 2009. A 3-day 24 h meal review method was used to collect diet data and to calculate the DII score. Serum uric acid was obtained to determine hyperuricemia levels. Subjects were divided into a hyperuricemia group and a non-hyperuricemia group, according to their serum uric acid level. Multilevel logistic regression models were used to examine the association between DII scores and hyperuricemia. Results: After adjusting for covariates, a higher DII score was determined to be associated with a higher risk of hyperuricemia. Compared to those in the highest DII score group, the lower DII score group had an inverse association with hyperuricemia risk (Q2: 0.83, 95% CI: 0.70–0.99; Q3: 0.72, 95% CI: 0.60–0.86; Q4: 0.73, 95% CI: 0.61–0.88). The intake of energy-adjusted protein, total fat, MUFAs, PUFAs and saturated fatty acid was higher in the hyperuricemia group. Conclusions: A higher DII score is significantly associated with a higher risk of hyperuricemia. Controlling the intake of pro-inflammatory food may be beneficial to reduce the risk of hyperuricemia.

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Vitamin C alleviates hyperuricemia nephropathy by reducing inflammation and fibrosis

Cited by 29 publications

References 47 publications

Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid

Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid

Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia

Dietary Inflammatory Index and the Risk of Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents

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