Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt/β-Catenin/ATF4 Signaling Pathways

Choi, Hyoung Gwon; Kim, Gyeong-Ji; Yoo, Han-Seok; Song, Da; Chung, Kang-Hyun; Lee, Kwon-Jai; Koo, Young Tae; An, Jeung Hee

doi:10.3390/nu11030506

Cited by 53 publications

(53 citation statements)

References 67 publications

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“…Prior work has confirmed the importance of vitamin C in maintaining bone health by demonstrating a positive association with vitamin C intake and BMD at the femoral neck and lumbar spine along with a 33% lower risk of osteoporosis [ 24 ]. These effects may stem from the suppression of osteoclast activity and the differentiation of osteoblasts by vitamin C [ 25 , 26 ]. In this regard, the association between vitamin C metabolism and P1NP levels may reflect the well-established osteogenic effects of vitamin C on osteoblast differentiation and matrix deposition [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic Associations with Serum Bone Turnover Markers

et al. 2020

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Bone is a dynamic tissue that is in a constant state of remodeling. Bone turnover markers (BTMs), procollagen type I N-terminal propeptide (P1NP) and C-terminal telopeptides of type I collagen (CTX), provide sensitive measures of bone formation and resorption, respectively. This study used ultra-high-resolution metabolomics (HRM) to determine plasma metabolic pathways and targeted metabolites related to the markers of bone resorption and formation in adults. This cross-sectional clinical study included 34 adults (19 females, mean 27.8 years), without reported illnesses, recruited from a US metropolitan area. Serum BTM levels were quantified by an ELISA. Plasma HRM utilized dual-column liquid chromatography and mass spectrometry to identify metabolites and metabolic pathways associated with BTMs. Metabolites significantly associated with P1NP (p < 0.05) were significantly enriched in pathways linked to the TCA cycle, pyruvate metabolism, and metabolism of B vitamins important for energy production (e.g., niacin, thiamin). Other nutrition-related metabolic pathways associated with P1NP were amino acid (proline, arginine, glutamate) and vitamin C metabolism, which are important for collagen formation. Metabolites associated with CTX levels (p < 0.05) were enriched within lipid and fatty acid beta-oxidation metabolic pathways, as well as fat-soluble micronutrient pathways including, vitamin D metabolism, vitamin E metabolism, and bile acid biosynthesis. P1NP and CTX were significantly related to microbiome-related metabolites (p < 0.05). Macronutrient-related pathways including lipid, carbohydrate, and amino acid metabolism, as well as several gut microbiome-derived metabolites were significantly related to BTMs. Future research should compare metabolism BTMs relationships reported here to aging and clinical populations to inform targeted therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Metabolomic Associations with Serum Bone Turnover Markers

et al. 2020

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“…VC deficiency was also linked to increased expression of tumour necrosis factor ligand superfamily member 11 (RANKL), which acts as a critical osteoclast and bone resorption inducer, but also an inflammatory mediator [29]. A recent study has demonstrated that ostoblastogenesis and osteoclastogenesis in osteoporosis rat models are in fact regulated by a shared serine/threonine kinase and mitogen-activated protein kinase (MAPK) signalling pathway, which is fine-tuned by vitamin C [35].…”

Section: Studies On Animal Modelsmentioning

confidence: 99%

Role of Vitamin C in Osteoporosis Development and Treatment—A Literature Review

et al. 2020

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Osteoporosis and associated low energy fractures are a significant clinical problem, especially in the elderly population. The occurrence of a hip fracture is associated with significant mortality and a high risk of disability. For this, apart from the treatment of osteoporosis, effective prevention of both the development of the disease and related fractures is extremely important. One aspect of osteoporosis prevention is proper dietary calcium intake and normal vitamin D3 levels. However, there is some evidence for a potential role of vitamin C in osteoporosis and fracture prevention, too. This review aims to summarize the current knowledge about the role of vitamin C in osteoporosis development, prevention and treatment. The PubMed/Medline search on the role of vitamin C in bone metabolism database was performed for articles between 2000 and May 2020. Reports from in vitro and animal studies seem promising. Epidemiological studies also indicate the positive effect of high vitamin C content in the daily diet on bone mineral density. Despite promising observations, there are still few observational and intervention studies and their results do not allow for unequivocal determination of the benefits of high daily intake of vitamin C or its long-term supplementation.

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“…Enhances osteoblastogenesis and inhibits osteoclastogenesis via Wnt/β-catenin signaling [22]. Vitamin C contributes to normal function of bones and teeth (EFSA opinion).…”

Section: Vitamin C (Ascorbic Acid)mentioning

confidence: 99%

Do Dietary Supplements and Nutraceuticals Have Effects on Dental Implant Osseointegration? A Scoping Review

et al. 2020

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Several factors affect dental implant osseointegration, including surgical issues, bone quality and quantity, and host-related factors, such as patients’ nutritional status. Many micronutrients might play a key role in dental implant osseointegration by influencing some alveolar bone parameters, such as healing of the alveolus after tooth extraction. This scoping review aims to summarize the role of dietary supplements in optimizing osseointegration after implant insertion surgery. A technical expert panel (TEP) of 11 medical specialists with expertise in oral surgery, bone metabolism, nutrition, and orthopedic surgery performed the review following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP identified micronutrients from the “European Union (EU) Register of nutrition and health claims made on foods” that have a relationship with bone and tooth health, and planned a PubMed search, selecting micronutrients previously identified as MeSH (Medical Subject Headings) terms and adding to each of them the words “dental implants” and “osseointegration”. The TEP identified 19 studies concerning vitamin D, magnesium, resveratrol, vitamin C, a mixture of calcium, magnesium, zinc, and vitamin D, and synthetic bone mineral. However, several micronutrients are non-authorized by the “EU Register on nutrition and health claims” for improving bone and/or tooth health. Our scoping review suggests a limited role of nutraceuticals in promoting osseointegration of dental implants, although, in some cases, such as for vitamin D deficiency, there is a clear link among their deficit, reduced osseointegration, and early implant failure, thus requiring an adequate supplementation.

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Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt/β-Catenin/ATF4 Signaling Pathways

Cited by 53 publications

References 67 publications

Metabolomic Associations with Serum Bone Turnover Markers

Metabolomic Associations with Serum Bone Turnover Markers

Role of Vitamin C in Osteoporosis Development and Treatment—A Literature Review

Do Dietary Supplements and Nutraceuticals Have Effects on Dental Implant Osseointegration? A Scoping Review

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