Vitamin C

Lykkesfeldt, Jens; Michels, Alexander J.; Frei, Balz

doi:10.3945/an.113.005157

Cited by 145 publications

(110 citation statements)

References 4 publications

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“…The long-term lack of vitamin C leads to scurvy, a pathological process caused prima rily by a violation of collagen production and manifested in the destruction of blood vessels, disorders in the formation of bone tissue and attachment of the periosteum to the bones as well as loosening of teeth [21,40]. In addition, a decrease in the level of collagen leads to a violation of the architectonics of the lung tissue, which causes primary pneumonia or provokes the development of secondary ones, which are the leading complication and the main cause of death in scurvy [28].…”

mentioning

confidence: 99%

Protective Activity of Ascorbic Acid at Influenza Infection

Zarubaev

Slita

Lavrentyeva

et al. 2018

Russian Journal of Infection and Immunity

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Abstract. Ascorbic acid (vitamin C, AA) is an essential nutrient of the human diet due to its participation on numerous regulatory and enzymatic processes. AA takes part in such vital physiological processes as hormone production, collagen synthesis, stimulation of the immune system, etc. In the present review the activities of AA are considered that provide its protective effect at influenza infection. This effect can be result of direct virus-inhibiting activity of AA as well as of anti-inflammatory and antioxidant properties. Oxidative stress during influenza infection leads to nonspecific damage of the pulmonary tissue and subsequent inflammation of the lungs. The antioxidant activity of AA results in alleviation of infection due to suppression of tissue damage as well as in inhibition of reactive oxygen species-mediated signal transduction and regulatory reactions. After oxidation by ROS, AA is converted to dehydroascorbic acid (DAA) and inhibits the key enzymes of NF-κB pathway, such as kinases IKKα and IKKβ. AA itself blocks the activity of another component of the NF-kB pathway, kinase IKKβ(SS/EE), whose activity is directed to the phosphorylation of the factor IκBα. As a result, activation of NF-κB and its transport to the nucleus does not occur. Thus, AA performs a dual function: first, it neutralizes free radicals, preventing them from activating NF-κB, and secondly, the product of its oxidation, DAA, further blocks the activation of this pathway. In addition, in some cases AA results in the decrease in the infectious activity of influenza virus that is not due to the antioxidant activity of AA, but to direct virus-inhibiting activity. Taken together, the presented data suggests that the use of drugs with antiviral and antioxidant activity, as a combination of individual drugs or, as in the case of AA, as a single drug with complex activity, for treatment of influenza has advantages over the etiotropic drug monotherapy scheme. Резюме. Аскорбиновая кислота (витамин C, АК) является важным пищевым компонентом для человека благо-даря ее роли в различных регуляторных и ферментативных процессах. АК принимает участие в таких жизненно важных физиологических процессах, как продукция гормонов, синтез коллагена, стимуляция иммунной си-стемы и пр. В настоящем обзоре рассмотрена активность АК, обеспечивающая ее протективный эффект при гриппозной инфекции. Этот эффект может быть обусловлен прямой вирусингибирующей активностью АК, а также ее противовоспалительными и антиоксидантными свойствами. Окислительный стресс при гриппе ведет к неспецифическому повреждению ткани легких и развитию воспаления. Антиоксидантная активность АК приводит к облегчению течения инфекции вследствие снижения уровня повреждения ткани и ингибиро-

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mentioning

confidence: 99%

Protective Activity of Ascorbic Acid at Influenza Infection

Zarubaev

Slita

Lavrentyeva

et al. 2018

Russian Journal of Infection and Immunity

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“…The highest concentrations of vitamin C are found in the brain, eye, and adrenal gland. 8,27 Vitamin C absorption, tissue distribution, and excretion are tightly controlled by tissue specific. The absorption of vitamin C in human occurs in the buccal mucosa, stomach and the small intestine through passive diffusion and active transport system.…”

Section: Vitamin Cmentioning

confidence: 99%

“…There is a gradual decline in the amount of vitamin C as foods age. 27,28 The current recommended dietary daily allowance of vitamin C differs between gender dan ages. They are 75 mg/d for women and 90 mg/d for men.…”

Section: Vitamin Cmentioning

confidence: 99%

“…They are 75 mg/d for women and 90 mg/d for men. 27 Many studies have shown health benefits of vitamin C include reduced susceptibility to and duration of the common cold, and reduced risk of cardiovascular disease, cancer, and other degenerative diseases, lowered blood pressure and cholesterol levels, helped thin the blood and protects it against oxidation, helped regulate nervous systems. With adequate intake, it was highly protective against stroke and heart attack.…”

Section: Vitamin Cmentioning

confidence: 99%

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Is vitamin C able to reduce hyperuricemia

Hantono¹

2019

Int J Res Med Sci

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Hyperuricemia is defined as high levels of blood uric acid, the product of purine metabolism, which can form uric acid crystals and lead to become gout. Gout is a systemic disease that results from chronic elevation of uric acid levels above the threshold point and form the deposition of monosodium urate (MSU) crystals in tissues, mainly in and around the joints forming tophi. The impact of gout and its associated conditions can cause deformity, morbidity and mortality. Vitamin C is shown to has beneficial effect in lowering serum uric acid level in hyperuricemia patients with unknown mechanism. But it is still debatable whether using or not using and the dose of vitamin C because giving large doses also had no effect on serum uric acid concentration, uric acid excretion and clearance by the kidney, and even can cause adverse effects.

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“…Vitamin C (ascorbic acid) is anticipated to have such an effect, and is to be investigated in this study to understand the potency and the mechanism behind it. Vitamin C is an essential nutrient that has been found to contribute to many aspects of human health, from the very rst reports on protection against scurvy to numerous contemporary evidence on its role in maintaining immunity and cardiovascular health; and cancer and chronic disease prevention, many of which were attributed to its antioxidant effects [15,16]. In this study, of particular importance are its roles to prevent/treat dental caries and maintain oral health, which remain unchallenged despite the recent conglomeration of literature.…”

Section: Introductionmentioning

confidence: 99%

Investigation on the effect of vitamin C on growth & biofilm-forming potential of Streptococcus mutans isolated from patients with dental caries

Eydou

Jad

Elsayed

et al. 2020

Preprint

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Background: Streptococcus mutans is a major cause of dental caries. Its capacity to produce biofilm is fundamental in the pathogenesis of this ubiquitous condition. As maintaining a healthy dentition is a genuine goal given the contemporary advance in caries control, researchers are striving to achieve a breakthrough in caries therapy. We are taking the anti-cariogenic properties of vitamin C a step-further, considering the well-known evidence of the inversely proportionate relationship between salivary levels of vitamin C and dental caries. The aim of this study was to determine MIC, MBC, biofilm prevention concentration (BPC), and derivative measures of vitamin C against fresh clinical isolates of S. mutans to evaluate its efficacy as an anti-cariogenic agent.Results: Based on the data of four independent experiments done in quadruplicates, we found a concentration-dependent inhibitory effect of vitamin C on all S. mutans strains tested. The average MBC, MIC, and BPC of vitamin C were found to be 10.16, 9.38, and 5.61 mg/ml, respectively. Spectrophotometric quantitation of crystal violet showed diminished biofilm formation in the presence of vitamin C (p < 0.05). When compared with gentamicin, vitamin C produced a zone of inhibition that was three times as large against the clinical isolates.Conclusion: Our results show that vitamin C has a negative effect on S. mutans growth and biofilm formation. Being the first to meticulously utilize BPC to explore a well-known effect of vitamin C, this report aims to help in the instigation of trials of higher evidence that will ultimately culminate in repurposing vitamin C as a novel anti-cariogenic agent, albeit further studies are required to provide auxiliary evidence in this context.

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Vitamin C

Cited by 145 publications

References 4 publications

Protective Activity of Ascorbic Acid at Influenza Infection

Protective Activity of Ascorbic Acid at Influenza Infection

Is vitamin C able to reduce hyperuricemia

Investigation on the effect of vitamin C on growth & biofilm-forming potential of Streptococcus mutans isolated from patients with dental caries

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Vitamin C

Cited by 145 publications

References 4 publications

Protective Activity of Ascorbic Acid at Influenza Infection

Protective Activity of Ascorbic Acid at Influenza Infection

Is vitamin C able to reduce hyperuricemia

Investigation on the effect of vitamin C on growth &amp; biofilm-forming potential of Streptococcus mutans isolated from patients with dental caries

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Investigation on the effect of vitamin C on growth & biofilm-forming potential of Streptococcus mutans isolated from patients with dental caries