Vitamin B6

Ball, G. F. M.

doi:10.1007/978-1-4899-3414-7_10

Cited by 1 publication

(1 citation statement)

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“…[12][13][14][15] Adults with proper nutrition have serum vitamin B6 levels of 5 to 50 ng/mL. 12,[16][17][18] Semi-quantitative evaluation of OPLL severity. To examine the association between serum vitamin levels and the ossification severity, the distribution of spinal ligamentous ossification, including OPLL, OLF, ossification of the anterior longitudinal ligament (OALL), and ossification of the supra/interspinous ligament (OSIL), was evaluated using whole-spine computed tomography (CT).…”

Section: Study 2: Serological Validation Of the Nutritional Questionn...mentioning

confidence: 99%

Association Between Vitamin A Intake and Disease Severity in Early-Onset Heterotopic Ossification of the Posterior Longitudinal Ligament of the Spine

Endo

Imagama

Kato

et al. 2021

Global Spine Journal

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Study Design: A sex- and age-matched case-control study and a cross-sectional study. Objective: In our previous study, patients with early-onset (<50 years of age) ossification of the posterior longitudinal ligament (OPLL) had distinct features such as morbid obesity, a high prevalence of lifestyle-related diseases, and diffuse ossified lesions mainly affecting the thoracic spine. Our goals were to determine whether early-onset OPLL patients have unbalanced dietary habits and to identify nutritional factors associated with OPLL exacerbation. Methods: In Study 1, the simple brief-type self-administered diet history questionnaire (BDHQ) was used to compare nutrient intake levels of early-onset OPLL patients (n = 13) with those of sex- and age-matched non-OPLL controls (n = 39) or with those of common OPLL (onset age ≥ 50 years, n = 62). In Study 2, serological validation was conducted for thoracic OPLL patients (n = 77) and non-OPLL controls (n = 101) in a nationwide multicenter study in Japan. Results: The BDHQ showed that the early-onset OPLL patients had significantly lower intakes of vitamins A and B6 than non-OPLL controls. These results were validated by lower serum vitamins A and B6 levels in the early-onset thoracic OPLL patients. The severity of OPLL negatively correlated with serum vitamin A levels in male early-onset OPLL patients. The multiple regression analysis revealed that the severity of thoracic OPLL had an association with onset age and serum vitamin A level. Conclusions: Vitamin A deficiency resulting from unbalanced dietary habits is associated with exacerbation of male early-onset OPLL.

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Section: Study 2: Serological Validation Of the Nutritional Questionn...mentioning

confidence: 99%