Anti-Aging in dermatology is focused first on the prevention of skin aging with UV-protection (textiles, sunscreen), free radical scavengers, cell protecting substances such as vitamin B3 and removal of pollutants from the skin surface. For the correction of signs of early aging vitamin-A-acid derivatives in dermatological prescriptions and cosmetic ingredients such as retinol/retinaldehyde and vitamin C are the substances best studied. Topical hormonal prescriptions are additive options, but only if UV-damage has not been the leading culprit for skin aging. Vehicle controlled studies have evaluated new ingredients in cosmetics, that due to controlled trials, reduce superficial skin folds such as salicyloylphytophingosin, some peptides and low molecular weight hyaluronic acid. Modulators of a regular pigmentation are important for anti-aging preparations as an irregular spotty pigmentation characterises older age. Botanicals and growth factors are not thoroughly studied regarding the benefit, cost and risk ratio.