Vitamin B2 functionalized iron oxide nanozymes for mouth ulcer healing

Gu, Yunhao; Huang, Yixin; Qiu, Zhiyue; Xu, Zhuobin; Li, Dandan; Chen, Lei; Jiang, Jing; Gao, Lizeng

doi:10.1007/s11427-019-9590-6

Cited by 40 publications

(23 citation statements)

References 28 publications

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“…The metabolism of RF is inextricably linked to the kidney ( 12 ), suggesting that understanding the absorption and transport of RF is vital to studying the mechanism of anti-infection activity in vivo . In a mouse ulcer model, RF alleviated oral ulcers by exerting antioxidant and antibacterial activity and reducing the local secretion of inflammatory factors ( 57 ). Previously, 20 to 100 mg/kg of RF combined with azithromycin was shown to reduce the expression of tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ), interleukin-6 (IL-6), and monocyte chemoattractant protein 1 (MCP-1) in S. aureus infection ( 58 ).…”

Section: Discussionmentioning

confidence: 99%

Riboflavin Targets the Cellular Metabolic and Ribosomal Pathways of Candida albicans In Vitro and Exhibits Efficacy against Oropharyngeal Candidiasis

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Riboflavin Targets the Cellular Metabolic and Ribosomal Pathways of Candida albicans In Vitro and Exhibits Efficacy against Oropharyngeal Candidiasis

et al. 2023

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“…Thus, results demonstrated that Cur‐based nanozymes may serve as a promising therapeutic agent in clinical wound treatment. Gu et al [ 73 ] reported that vitamin B 2 (VB 2 ) modified iron oxide NPs as nanozymes (VB 2 ‐IONzymes) could improve the healing of ulcers through anti‐inflammatory and antibacterial performance. VB 2 ‐IONzymes hold enhanced POD‐, CAT‐, and SOD‐mimic activities, which increase the ROS‐scavenging ability and exert an antibacterial activity against Streptococcus mutans, S. aureus, and E. coli .…”

Section: Therapeutic Strategies Of Enzyme‐based Materials For Wound H...mentioning

confidence: 99%

Recent Advances in Enzyme‐Based Biomaterials Toward Diabetic Wound Healing

Wang

Luo

et al. 2022

Advanced NanoBiomed Research

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Diabetic wound, also known as diabetic foot ulcer (DFU), is a form of chronic lesion that disrupts the patient's lifestyle and, in severe cases, may be fatal. Recent endeavors utilizing enzymes, particularly nanozymes in conjunction with other materials, have revealed the potential to treat diabetic wounds. Herein, the rational structural design of enzyme‐based biomaterials is summarized after presenting the types and processes of enzymes employed in diabetic wound healing, with the goal of better understanding the interaction between enzymes and other biological materials. The importance of enzyme catalytic activity, coupled with new therapeutic treatment strategies, is emphasized in the use of enzyme‐based biomaterials for diabetic wound healing. This review represents the most recent development in enzyme‐based biomaterials innovation for diabetic wound healing applications, and it can be used as a reference to guide other regenerative biomedicines from nanoenzyme biomaterials.

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“…It has been discovered that vitamin B2-modified iron oxide nanoparticle exhibited the further improvement of catalase-like, peroxidase-like, and SOD-like activities, conducting as a typical iron oxide nanozyme with triad activities. Particularly, VB2 modification remarkably improved SOD-like activity, in order to provide an ROS-scavenging ability, which may be an up-and-coming reagent for the cure of MU [ 51 ].…”

Section: Ros and Oral And Maxillofacial Disease-related Pathological ...mentioning

confidence: 99%

Reactive Oxygen Species Enlightened Therapeutic Strategy for Oral and Maxillofacial Diseases—Art of Destruction and Reconstruction

Zhang

Mei

et al. 2022

Biomedicines

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Reactive oxygen species (ROS) are byproducts of cell metabolism produced by living cells and signal mediators in biological processes. As unstable and highly reactive oxygen-derived molecules, excessive ROS production and defective oxidant clearance, or both, are associated with the pathogenesis of several conditions. Among them, ROS are widely involved in oral and maxillofacial diseases, such as periodontitis, as well as other infectious diseases or chronic inflammation, temporomandibular joint disorders, oral mucosal lesions, trigeminal neuralgia, muscle fatigue, and oral cancer. The purpose of this paper is to outline how ROS contribute to the pathophysiology of oral and maxillofacial regions, with an emphasis on oral infectious diseases represented by periodontitis and mucosal diseases represented by oral ulcers and how to effectively utilize and eliminate ROS in these pathological processes, as well as to review recent research on the potential targets and interventions of cutting-edge antioxidant materials. The PubMed, Web of Science, and Embase databases were searched using the MesH terms “oral and maxillofacial diseases”, “reactive oxygen species”, and “antioxidant materials”. Irrelevant, obsolete, imprecise, and repetitive articles were excluded through screening of titles, abstracts, and eventually full content. The full-text data of the selected articles are, therefore, summarized using selection criteria. While there are various emerging biomaterials used as drugs themselves or delivery systems, more attention was paid to antioxidant drugs with broad application prospects and rigorous prophase animal experimental results.

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Vitamin B2 functionalized iron oxide nanozymes for mouth ulcer healing

Cited by 40 publications

References 28 publications

Riboflavin Targets the Cellular Metabolic and Ribosomal Pathways of Candida albicans In Vitro and Exhibits Efficacy against Oropharyngeal Candidiasis

Riboflavin Targets the Cellular Metabolic and Ribosomal Pathways of Candida albicans In Vitro and Exhibits Efficacy against Oropharyngeal Candidiasis

Recent Advances in Enzyme‐Based Biomaterials Toward Diabetic Wound Healing

Reactive Oxygen Species Enlightened Therapeutic Strategy for Oral and Maxillofacial Diseases—Art of Destruction and Reconstruction

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