Vitamin B12 may play a preventive role in esophageal precancerous lesions: a case–control study based on markers in blood and 3-day duplicate diet samples

Pan, Da; Wang, Shaokang; Su, Ming; Sun, Guiju; Zhu, Xiaopan; Chaeipeima, Mahsa Ghahvechi; Guo, Ziqi; Wang, Niannian; Zhang, Ziyu; Cui, Mengjing

doi:10.1007/s00394-021-02516-0

Cited by 10 publications

(10 citation statements)

References 43 publications

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“…Marley et al found that B12 from foods, but not from foods and supplements, was associated with pancreas cancer [ 63 ]. This indicates the absence of threshold and a possible confounding by other components in the diet associated with B12, whereas, other studies did not show significant associations with food B12 or total B12 [ 38 , 64 , 65 , 66 ]. Associations with an intake level within the population intake range could be driven by other food components, or dietary patterns that are rich in B12.…”

Section: Discussionmentioning

confidence: 74%

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High Plasma Vitamin B12 and Cancer in Human Studies: A Scoping Review to Judge Causality and Alternative Explanations

Obeid

2022

Nutrients

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Patients with cancer have been reported to show elevated plasma concentrations of vitamin B12, thus causing uncertainties regarding safety of vitamin B12. We conducted a systematic literature search and a scoping review of human studies published in PubMed between January 2005 and March 2022, to investigate the association between vitamin B12 (concentrations of B12 biomarkers, intake, and genetic determinants) and cancer. Except for liver cancer, the association between plasma vitamin B12 concentrations and cancer was not consistent across the studies. Vitamin B12 intake from food, or food and supplements, showed even less consistent associations with cancer. There was no evidence for temporality, coherence, or a biologically meaningful dose-response relationship between plasma vitamin B12 concentrations and cancer. Genetically determined high plasma vitamin B12 was likely to be associated with cancer. Available randomized controlled trials have used a high dose of multivitamin supplements and cancer was the unplanned outcome, thus the causality of B12 in cancer cannot be judged based on these trials. Additionally, low plasma vitamin B12 concentrations were common in patients with cancer. Therefore, there is not sufficient evidence to assume that high plasma vitamin B12, high B12 intake, or treatment with pharmacological doses of vitamin B12, is causally related to cancer. Low vitamin B12 status in patients with cancer needs to be diagnosed and treated in order to prevent the hematological and neurological sequela of the deficiency.

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Section: Discussionmentioning

confidence: 74%

“…Three studies reported parallel measurements of plasma total B12 and holoTC concentrations in patients with esophageal squamous cell carcinoma, prostate, and lung cancers [ 38 , 55 , 56 ]. We calculated the ratio of mean (or median) plasma B12/to holoTC concentrations (both in pmol/L) in the patients and the controls from each study.…”

Section: Discussionmentioning

confidence: 99%

High Plasma Vitamin B12 and Cancer in Human Studies: A Scoping Review to Judge Causality and Alternative Explanations

Obeid

2022

Nutrients

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“…This study was carried out in a high-incidence area for ESCC located in Huai’an District, Huai’an City, Jiangsu Province, China, where the crude incidence rate from 1998 to 2016 was 91.85/100000[ 19 ]. As described in our previous studies[ 20 - 22 ], the Early Diagnosis and Early Treatment Project of Esophageal Cancer (EDETPEC) supported by the government and Cancer Foundation of China has been carried out in the endemic regions including Huai’an District since 2010. Local residents were required to undergo routine endoscopies.…”

Section: Methodsmentioning

confidence: 99%

Inverse relations between Helicobacter pylori infection and risk of esophageal precancerous lesions in drinkers and peanut consumption

Pan¹,

Sun²,

Su³

et al. 2022

WJGO

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BACKGROUND Helicobacter pylori ( H. pylori ) is a Gram-negative bacterium found in the upper digestive tract. Although H. pylori infection is an identified risk factor for gastric cancer, its role in esophageal squamous cell carcinoma (ESCC) remains a topic of much debate. AIM To evaluate the association between H. pylori infection and the risk of precancerous lesions of ESCC, and further explore the association between dietary factors and the risk of H. pylori infection. METHODS Two hundred patients with esophageal precancerous lesions (EPL) aged 63.01 ± 6.08 years and 200 healthy controls aged 62.85 ± 6.03 years were included in this case-control study. Epidemiological data and qualitative food frequency data were investigated. Enzyme-linked immunosorbent assay measuring serum immunoglobulin G antibodies was used to determine H. pylori seropositivity. An unconditional logistic regression model was used to assess the association between H. pylori infection and EPL risk dichotomized by gender, age, and the use of tobacco and alcohol, as well as the association between dietary factors and the risk of H. pylori infection. RESULTS A total of 47 (23.5%) EPL cases and 58 (29.0%) healthy controls had positive H. pylori infection. An inverse relation between H. pylori infection and the risk of EPL was found in the group of drinkers after adjustment for covariates [odds ratio (OR) = 0.32, 95% confidence interval (95%CI): 0.11-0.95]. Additionally, peanut intake was significantly associated with a decreased risk of H. pylori infection (OR = 0.39, 95%CI: 0.20-0.74). CONCLUSION Our study suggested that H. pylori infection may decrease the risk of EPL for drinkers in a rural adult Chinese population, and the consumption of peanut may reduce the risk of H. pylori infection. These findings should be framed as preliminary evidence, and further studies are required to address whether the mechanisms are related to the localization of lesions and alcohol consumption.

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“… 1 Huai’an District, an inland low socio-economic rural area located in the Northern Jiangsu Province of China, is a high-risk area for EC and has been reported to have a distinct epidemiological pattern. 2 - 8 Environmental and dietary factors play the most significant roles in the development of EC as the local residents are highly exposed to N-nitrosamines, mycotoxins, and other carcinogens from drinking water, pickled food, fried food, hot food, and stored grains. 3 , 4 , 6 , 9 - 11 From 2008 to 2012, the crude incidence and mortality rates of EC in the Huai’an District were 96.15/100,000 and 63.25/100,000 respectively, ranked at the first position among all types of cancer, and esophageal squamous cell carcinoma (ESCC) has always been the predominant histological subtype.…”

Section: Introductionmentioning

confidence: 99%

“…15 , 16 However, although many EC studies have been conducted in Huai’an District, detailed EC statistics and the trend of incidence of the district have never been reported in previous studies. 3 , 6 , 17 - 19 Therefore, this study aimed to provide a detailed report of EC statistics and a clear comparable figure of the trends in incidence and mortality rates of EC in Huai’an District, Huai’an City, Jiangsu Province, China between 1998-2016. This was based on the cancer registry report provided by Huai’an District Center for Disease Control and Prevention (CDC).…”

Section: Introductionmentioning

confidence: 99%

Trends in Incidence and Mortality of Esophageal Cancer in Huai’an District, a High-Risk Area in Northern Jiangsu Province, China

et al. 2022

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Purpose This study aimed to provide a clear comparable figure of the trends in incidence and mortality rates of esophageal cancer (EC) in Huai’an District, Huai’an City, Jiangsu Province, China, a high-risk area for EC. Methods The data for age- and sex-specific incidence rates between 1998 and 2016, the mortality rates in 1990-2016 and the number of EC patients were obtained from Huai’an District Cancer Registry. Crude rates, Age-standardized rates (ASRs) by world standard population and truncated age-standardized rates of EC incidence and mortality were calculated. The joinpoint regression analysis was used to calculate the annual percent changes (APC), average annual percent changes (AAPC), and their 95% confidence intervals (CIs). Results Overall, 20,892 new EC cases and 20,806 EC deaths were registered in Huai’an District. ASR of EC incidence from 1998 to 2016 and mortality from 1990 to 2016 were 73.32/100,000 and 60.03/100,000, respectively. The ASR illustrated that the incidence of EC had significant downward trends in total, male and female (AAPC = −4.65, −4.90, and −5.51, respectively, p <.01). The age-specific incidence and mortality rates of EC increased dramatically in people over the age of 40, and peaked in people between the ages 70-74. In the subdivisions of Huai’an District, geographical diversities in the crude incidence and mortality rates of EC were found. Conclusion In summary, the incidence and mortality rates of EC showed downward trends in Huai’an District. However, the burden of EC still remained serious in this high-risk area. Cost-effective methods of intervention and health education should be enhanced for improving EC prevention.

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Vitamin B12 may play a preventive role in esophageal precancerous lesions: a case–control study based on markers in blood and 3-day duplicate diet samples

Cited by 10 publications

References 43 publications

High Plasma Vitamin B12 and Cancer in Human Studies: A Scoping Review to Judge Causality and Alternative Explanations

High Plasma Vitamin B12 and Cancer in Human Studies: A Scoping Review to Judge Causality and Alternative Explanations

Inverse relations between Helicobacter pylori infection and risk of esophageal precancerous lesions in drinkers and peanut consumption

Trends in Incidence and Mortality of Esophageal Cancer in Huai’an District, a High-Risk Area in Northern Jiangsu Province, China

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