Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin

Verma, Ayushi; Sharma, Shweta; Gupta, Pramod; Singh, Awadhesh Kumar; Banala, Venkatesh Teja; Dwivedi, Pankaj; Gupta, Girish Kumar; Trivedi, Ritu; Mishra, Prabhat Ranjan

doi:10.1016/j.actbio.2015.12.017

Cited by 113 publications

(59 citation statements)

References 26 publications

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“…Verma and colleagues synthesized insulin-loaded calcium phosphate nanoparticles (Insu-Cap NPs) that were coated with alternating layers of sodium alginate and chitosan-vitamin B12 conjugate (B12-LbL-Insu-Cap NPs) [172]. Insu-Cap NPs coated with alternate layers of chitosan and sodium alginate were also developed (LbL-Insu-Cap NPs) to assess the effect of vitamin B12 on targeted oral delivery.…”

Section: Recent Developments In Targeting Oral Nanoparticles To Spmentioning

confidence: 99%

“…In vivo studies in rats showed increased localization of fluorescently labeled B12-LbL-Insu-Cap NPs in the ileum compared to LbL-Insu-Cap NPs. In comparison to subcutaneous insulin (5 IU/kg), oral administration of B12-LbL-Insu-Cap NPs and LbL-Insu-Cap NPs (both equivalent to 50 IU/kg insulin) showed relative bioavailability of ~ 27% and ~ 6%, respectively [172]. B12-LbL-Insu-Cap NPs achieved similar glucose lowering effects to that of subcutaneous insulin, whereas LbL-Insu-Cap NPs did not cause a measurable hypoglycemic effect after oral administration (Figure 8) [172].…”

Section: Recent Developments In Targeting Oral Nanoparticles To Spmentioning

confidence: 99%

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Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

Date

Hanes

Ensign

2016

Journal of Controlled Release

355

192

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The oral route is a preferred method of drug administration, though achieving effective drug delivery and minimizing off-target side effects is often challenging. Formulation into nanoparticles can improve drug stability in the harsh gastrointestinal (GI) tract environment, providing opportunities for targeting specific sites in the GI tract, increasing drug solubility and bioavailability, and providing sustained release in the GI tract. However, the unique and diverse physiology throughout the GI tract, including wide variation in pH, mucus that varies in thickness and structure, numerous cell types, and various physiological functions are both a barrier to effective delivery and an opportunity for nanoparticle design. Here, nanoparticle design aspects to improve delivery to particular sites in the GI tract are discussed. We then review new methods for evaluating oral nanoparticle formulations, including a short commentary on data interpretation and translation. Finally, the state-of-the-art in preclinical targeted nanoparticle design is reviewed.

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Section: Recent Developments In Targeting Oral Nanoparticles To Spmentioning

confidence: 99%

Section: Recent Developments In Targeting Oral Nanoparticles To Spmentioning

confidence: 99%

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

Date

Hanes

Ensign

2016

Journal of Controlled Release

355

192

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“…Recently, layer by layer (LBL) coated NPs have attracted considerable attention, which are composed of oppositely charged polyelectrolyte (like chitosan, alginate, polyacrylic acid, polyallylamine HCl, etc.) deposited over a core (Verma et al, 2016). These LBL coated NPs system have especially shown significant impact on stability and oral bioavailability related to protein delivery in GI tract.…”

Section: Nanoparticles Based On Combination Of Polyanions and Polycatmentioning

confidence: 99%

“…Surface-functionalized for NPs with acid-stable targeting ligands, including vitamins (Verma et al, 2016), lectin (Akande et al, 2010), and small peptides, for differential retention and uptake along the GI tract have been researched. Additionally, novel peptides were selected using in vivo phage display to identify peptides for targeted NP delivery to the M cells and follicle-associated epithelium (FAE) of the intestinal tract (Higgins et al, 2004).…”

Section: Nanoparticlesmentioning

confidence: 99%

pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms

et al. 2017

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PR China AbstractOral administration is a desirable alternative of parenteral administration due to the convenience and increased compliance to patients, especially for chronic diseases that require frequent administration. The oral drug delivery is a dynamic research field despite the numerous challenges limiting their effective delivery, such as enzyme degradation, hydrolysis and low permeability of intestinal epithelium in the gastrointestinal (GI) tract. pH-Responsive carriers offer excellent potential as oral therapeutic systems due to enhancing the stability of drug delivery in stomach and achieving controlled release in intestines. This review provides a wide perspective on current status of pH-responsive oral drug delivery systems prepared mainly with organic polymers or inorganic materials, including the strategies used to overcome GI barriers, the challenges in their development and future prospects, with focus on technology trends to improve the bioavailability of orally delivered drugs, the mechanisms of drug release from pH-responsive oral formulations, and their application for drug delivery, such as protein and peptide therapeutics, vaccination, inflammatory bowel disease (IBD) and bacterial infections.

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“…Recent advances show also development of FP-NPs systems from layer by layer (LBL). LBL coating of NPs are prepared as strategy to provide a better molecule protection against gastric enzymes, as well as a delayed release, but for prolonged period of time [28]. LBL may be composed of chitosan, alginate, poly(allylamine) (PAA) or PAAc.…”

Section: Fp Solid Particles Systems As Enhancement Alternative Of Senmentioning

confidence: 99%

Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules

et al. 2016

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Currently, many sensitive molecules have been studied for effective oral administration. These substances are biologically active compounds that mainly suffer early degradation in the gastrointestinal tract (GIT) and physicochemical instability, inactivation and poor solubility and permeability. The sensibility of the biomolecules has limited their oral administration in the body and today is an important research topic to achieve desired effects in medicine field. Under this perspective, various enhancement approaches have been studied as alternatives to increase their oral bioavailability. Some of these strategies include functionalized polymers to provide specific useful benefits as protection to the intestinal tract by preventing its degradation by stomach enzymes, to increase their absorption, permeability, stability, and to make a proper release in the GIT. Due to specific chemical groups, shapes and sizes, morphologies, mechanical properties, and degradation, recent advances in functionalized polymers have opened the door to great possibilities to improve the physicochemical characteristics of these biopharmaceuticals. Today, many biomolecules are found in basic studies, preclinical steps, and others are late stage clinical development. This review summarizes the contribution of functionalized polymers to enhance oral bioavailability of sensitive molecules and their application status in medicine for different diseases. Future trends of these polymers and their possible uses to achieve different formulation goals for oral delivery are also covered in this manuscript.

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Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin

Cited by 113 publications

References 26 publications

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms

Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules

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