Vitamin B12, folate and homocysteine concentrations during pregnancy and early signs of atherosclerosis at school-age

Monasso, Giulietta S; Felix, Janine F.; Heil, Sandra G.; Rijke, Yolanda B. de; Gaillard, Romy; Jaddoe, Vincent W. V.

doi:10.1016/j.clnu.2021.08.001

Cited by 6 publications

(7 citation statements)

References 48 publications

(71 reference statements)

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“…We used the overall mean carotid intima‐media thickness (mm) and carotid distensibility (kPa −1 × 10 −3 ) as outcomes of interest. In a reproducibility study, the interobserver and intraobserver intraclass correlation coefficients were >0.85 23 …”

Section: Methodsmentioning

confidence: 89%

“…As described in detail previously, we measured common carotid artery intima-media thickness and distensibility using the Logiq E9 (GE Medical Systems, Wauwatosa, WI, USA) device. 23 Subsequent offline analyses were performed using the application Carotid Studio (Cardiovascular Suite [Quipu srl, Pisa, Italy]). Carotid intima-media thickness was computed at the far wall as the average distance between lumen-intima and media-adventitia borders.…”

Section: Common Carotid Artery Intima-media Thickness and Distensibilitymentioning

confidence: 99%

“…In a reproducibility study, the interobserver and intraobserver intraclass correlation coefficients were >0.85. 23…”

Section: Common Carotid Artery Intima-media Thickness and Distensibilitymentioning

confidence: 99%

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Body fat, pericardial fat, liver fat and arterial health at age 10 years

et al. 2022

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Summary Background Body mass index is associated with carotid intima‐media thickness and distensibility in adults and children. Objective To examine whether general and specific fat depots are associated with these markers of arterial health at school age. Methods This cross‐sectional analysis was embedded in a population‐based prospective cohort study among 4708 children aged 10 years. Body, lean and fat mass index were estimated by dual‐energy X‐ray absorptiometry. Pericardial, visceral and liver fat were estimated by magnetic resonance imaging. Carotid intima‐media thickness and distensibility were measured by ultrasound. Results A 1‐standard‐deviation‐score (SDS) higher body mass index was associated with higher carotid intima‐media thickness (0.06 SDS, 95% confidence interval [CI]: 0.03–0.08) and lower distensibility (−0.17 SDS, 95% CI: −0.20 to −0.14). These associations tended to be similar for lean mass index. A 1‐SDS higher fat mass index was associated with lower carotid intima‐media thickness (−0.08 SDS, 95% CI: −0.11 to −0.05) and lower distensibility (−0.10 SDS, 95% CI: −0.14 to −0.07). A 1‐SDS higher liver fat fraction was associated with lower carotid intima‐media thickness (−0.04 SDS, 95% CI: −0.08 to −0.00) and lower distensibility (−0.06 SDS, 95% CI: −0.10 to −0.03). We observed similar associations for visceral fat. Conclusions At school age, lean and fat mass seem to be differentially related to carotid intima‐media thickness but not distensibility. Arterial development might be affected by lean mass, general and specific fat mass.

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Section: Methodsmentioning

confidence: 89%

Section: Common Carotid Artery Intima-media Thickness and Distensibilitymentioning

confidence: 99%

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Body fat, pericardial fat, liver fat and arterial health at age 10 years

et al. 2022

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“…As described in detail previously, we measured common carotid artery intima-media thickness and distensibility using the Logiq E9 (GE Medical Systems, Wauwatosa, WI) device. 27 Subsequent offline analyses were performed using the application Carotid Studio (Cardiovascular Suite (Quipu srl, Pisa, Italy)). Carotid intima-media thickness was computed at the far wall as the average distance between lumen-intima and media-adventitia borders.…”

Section: Methodsmentioning

confidence: 99%

“…In a reproducibility study, the interobserver and intraobserver intraclass correlation coefficients were >0.85. 27 …”

Section: Methodsmentioning

confidence: 99%

Fetal and Childhood Exposure to Parental Tobacco Smoking and Arterial Health at Age 10 Years

Monasso

Felix

Gaillard

et al. 2022

American Journal of Hypertension

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Background Exposure to parental tobacco smoking during fetal life and childhood is associated with adverse cardiovascular health outcomes. It is not known whether these adverse parental lifestyle exposures are also associated with changes in the structure and function of the carotid arteries in children aged 10 years. Methods In a population-based prospective cohort study among 4639 healthy children, we examined the associations of fetal exposure to maternal (no, first trimester only, continued), paternal (no, yes) and combined parental tobacco smoking (nonsmoking parents, mother only, father only, both parents smoked) with carotid intima-media thickness and distensibility at 10 years. We also assessed the associations of exposure to any parental tobacco smoking at ages 6 and 10 years with these outcomes. Results Compared with no exposure, fetal exposure to continued maternal smoking was not associated with carotid intima-media thickness (-0.04 standard-deviation-score (SDS); 95% Confidence Interval (CI): -0.13, 0.05) and distensibility (0 SDS, 95% CI: -0.09, 0.09) at age 10 years. Fetal exposure to two smoking parents was also not associated with carotid intima-media thickness (-0.07 SDS, 95% CI: -0.16, 0.02) and distensibility (0 SDS, 95% CI: -0.09, 0.10) at this age. Exposure to any parental smoking during childhood also was not associated with these outcomes at age 10 years. Conclusions Exposure to parental tobacco smoking during fetal life and childhood were not associated with markers of arterial health in children aged 10 years. Prevention strategies aiming at minimizing smoke exposure later in life are still relevant regarding arterial health.

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Helicobacter Pylori Infection Induces Intestinal Dysbiosis That Could Be Related to the Onset of Atherosclerosis

Avilés-Jiménez

2022

BioMed Research International

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Cardiovascular diseases represent one of the first causes of death around the world, and atherosclerosis is one of the first steps in the development of them. Although these problems occur mainly in elderly, the incidence in younger people is being reported, and an undetermined portion of patients without the classic risk factors develop subclinical atherosclerosis at earlier stages of life. Recently, both the H. pylori infection and the intestinal microbiota have been linked to atherosclerosis. The mechanisms behind those associations are poorly understood, but some of the proposed explanations are (a) the effect of the chronic systemic inflammation induced by H. pylori, (b) a direct action over the endothelial cells by the cytotoxin associated gene A protein, and (c) alterations of the lipid metabolism and endothelial dysfunction induced by H. pylori infection. Regarding the microbiota, several studies show that induction of atherosclerosis is related to high levels of Trimethylamine N-oxide. In this review, we present the information published about the effects of H. pylori over the intestinal microbiota and their relationship with atherosclerosis and propose a hypothesis to explain the nature of these associations. If H. pylori contributes to atherosclerosis, then interventions for eradication and restoration of the gut microbiota at early stages could represent a way to prevent disease progression.

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Vitamin B12, folate and homocysteine concentrations during pregnancy and early signs of atherosclerosis at school-age

Cited by 6 publications

References 48 publications

Body fat, pericardial fat, liver fat and arterial health at age 10 years

Body fat, pericardial fat, liver fat and arterial health at age 10 years

Fetal and Childhood Exposure to Parental Tobacco Smoking and Arterial Health at Age 10 Years

Helicobacter Pylori Infection Induces Intestinal Dysbiosis That Could Be Related to the Onset of Atherosclerosis

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