Vitamin B12 deficiency neuropathy; a rare diagnosis in young adults: a case report

Ekabe, Cyril Jabea; Kehbila, Jules; Abanda, Martin Hongieh; Kadia, Benjamin Momo; Sama, Carlson–Babila; Monekosso, G. L.

doi:10.1186/s13104-017-2393-3

Cited by 16 publications

(9 citation statements)

References 18 publications

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“…The diagnosis of Vitamin B 12 deficiency is challenging in resource limited-settings due to limited access to diagnostic tools and unfamiliarity with the disease, owing to its rarity especially in young people. This is the case reported by Ekabe et al [ 35 ]. A 28-year-old sub-Saharan female, presenting peripheral neuropathic symptoms, was treated with oral vitamin B 12 tablets at doses of 2 mg per day for three months.…”

Section: Vitamin B 12 and Neurological Disorderssupporting

confidence: 77%

A Brief Review on Vitamin B12 Deficiency Looking at Some Case Study Reports in Adults

Azzini¹,

Raguzzini²,

Polito³

2021

IJMS

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In the era of evidence-based medicine, the randomized clinical trial corresponds to the top step in the qualitative scale of the evidence available in the literature, while small series of cases or the description of individual cases occupy the last place. However, the latter represent an important part of clinical practice and have significantly influenced the evolution of medicine, contributing significantly to the advancement of scientific knowledge. Vitamin B12 deficiency shares several common symptoms that affect several tissues and organs with health aliments, so its diagnosis could be unobvious for the broad array of its effects and investigation methods used. In this review, we focused our attention on some case reports related to the vitamin B12 deficiency associated to anemia, neurologic disorders, and hyperhomocysteinemia. B12 deficiency reversal is simply achieved by prompt therapy, even though it is not the same for several disorders.

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Section: Vitamin B 12 and Neurological Disorderssupporting

confidence: 77%

A Brief Review on Vitamin B12 Deficiency Looking at Some Case Study Reports in Adults

Azzini¹,

Raguzzini²,

Polito³

2021

IJMS

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“…Vitamin B12 deficiency may lead to neuropsychiatric and hematological abnormalities. The relationship between vitamin B12 deficiency and peripheral neuropathy has been shown in previous studies [ 6 – 7 ].…”

mentioning

confidence: 54%

Investigation of the vitamin b12 deficiency with peripheral neuropathy in the type 2 diabetes mellitus using metformin

Olt

Oznas

2017

North Clin Istanbul

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OBJECTIVE:The relationship between vitamin B12 deficiency and peripheral neuropathy has been shown in a number of previous studies. Metformin is the indispensable first-line treatment for type 2 diabetes mellitus (DM) worldwide. One of the adverse effects of the use of metformin is vitamin B12 deficiency. In the present study, we investigated the relationship between vitamin B12 deficiency and peripheral neuropathy due to the use of metformin.METHODS:Patient’s laboratory and electromyography (EMG) data were retrospectively reviewed. Patients with no EMG report and other necessary information were excluded from the study.RESULTS:Eighty-six patients with type 2 DM using metformin were included in the study. Of these patients, 26 were males and 60 were females. The mean age of the patients was 55.1±7.7 years. The mean body mass index of the patients was 29.1±9.01 kg/m2. The mean HbA1c level of the patients was 8.6%±2.1%. The mean duration of diabetes was 8.02±5.4 years. The incidence of vitamin B12 deficiency was 38.4%. Peripheral neuropathy was detected in 33.7% patients. There was no statistically significant difference in vitamin B12 levels between patients with peripheral neuropathy and those without peripheral neuropathy (p=0.64).CONCLUSION:Therefore, it can be concluded that the lack of vitamin B12 secondary to the use of metformin did not significantly increase the frequency of peripheral neuropathy.

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“…Una de las hipótesis que puede explicar el daño cerebral, no directamente de la hiperhomocisteinemia sino de una deficiencia de folato y vitamina B12, es que debido a este último factor es posible que no se dé la vía de remetilación de la homocisteína, con poca o ninguna formación de metionina y SAM, que por hipometilación afectan las estructuras principales del sistema nervioso central, con consecuencias como el deterioro cognitivo y la enfermedad mental [34,35]; otras consecuencias relacionadas solo con la deficiencia de vitamina B12 pueden ser la neuropatía desmielinizante con degeneración combinada de la médula espinal, cuyo mecanismo fisiopatológico todavía se desconoce [36,37], y la neuropatía relacionada con anemia perniciosa o megaloblástica por deficiencia del factor intrínseco de la mucosa gástrica, que dificulta la absorción de la vitamina B12 [36,38].…”

Section: Efectos Cerebrovascularesunclassified

Homocisteína y trastornos neurocognitivos. ¿Una luz al final del túnel?

Salazar

2020

Med. Lab.

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El deterioro cognitivo es uno de los procesos que acompañan al envejecimiento y puede depender de factores nutricionales, genéticos o ambientales. La identificación de factores de riesgo modificables proporciona un enfoque esencial para la prevención de dicho deterioro y de los trastornos neurocognitivos. Uno de los factores de riesgo involucrados es la elevada concentración de homocisteína plasmática, la cual se ha relacionado con hallazgos histopatológicos en demencia senil y enfermedad de Alzheimer. Los diferentes estudios sobre esta asociación revelan inconsistencia o contradicción en los resultados. El propósito de esta revisión es relacionar la posible interacción de tres factores en la instalación y progresión del deterioro neurocognitivo: a) factores de tipo nutricional (homocisteína, ácido fólico y vitamina B12), b) la utilización de pruebas para el diagnóstico de disfunción o deterioro cognitivo como el Mini Examen del Estado Mental, y c) la presencia de variantes genéticas polimórficas de la enzima metilentetrahidrofolato reductasa. Una consecuencia directa de esta triple relación es que el tratamiento con ácido fólico y vitamina B12 logra disminuir las elevadas concentraciones de homocisteína plasmática, asumiendo que una mejoría en los síntomas clínicos de deterioro cognitivo puede retrasar los cambios relacionados con progresión a estados demenciales. La intervención temprana mediante políticas de promoción y prevención de la salud mental puede ser efectiva si se comienza con la administración de ácido fólico y vitamina B12 en los estadios iniciales de la alteración cognitiva, logrando así reducir sus funestas consecuencias. Las políticas de salud pública centradas en la salud mental de ancianos pueden identificar a las personas con disfunción cognitiva inicial a través de la promoción de la salud y medidas preventivas; en esta etapa puede ser posible la administración de vitaminas B para reducir o minimizar la progresión del deterioro cognitivo, que podría conducir a trastornos neurocognitivos como la demencia y la enfermedad de Alzheimer.

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Vitamin B12 deficiency neuropathy; a rare diagnosis in young adults: a case report

Cited by 16 publications

References 18 publications

A Brief Review on Vitamin B12 Deficiency Looking at Some Case Study Reports in Adults

A Brief Review on Vitamin B12 Deficiency Looking at Some Case Study Reports in Adults

Investigation of the vitamin b12 deficiency with peripheral neuropathy in the type 2 diabetes mellitus using metformin

Homocisteína y trastornos neurocognitivos. ¿Una luz al final del túnel?

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