Vitamin B12 deficiency might be related to sarcopenia in older adults

Bulut, Esra Ateş; Soysal, Pınar; Aydın, Ali Ekrem; Dokuzlar, Özge; Koçyiğit, Süleyman Emre; Işık, Ahmet Turan

doi:10.1016/j.exger.2017.05.017

Cited by 78 publications

(34 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is well established that albumin is positively associated with muscle mass [33]. It was also established that vitamin B12 deficiency may lead to sarcopenia [34]. This can explain the observed inverse association between albumin and vitamin B12 deficiency, although it is somewhat surprising, considering that the study population was relatively young and healthy.…”

Section: Discussionmentioning

confidence: 55%

Vitamin B12 Deficiency and the Role of Gender: A Cross-Sectional Study of a Large Cohort

et al. 2018

View full text Add to dashboard Cite

Background: Vitamin B12 deficiency is associated with hematological, neurological, and cardiovascular consequences. Epidemiologic data on these related illnesses indicate gender differences. Methods: A cross-sectional study was designed to examine gender differences in vitamin B12 deficiency among a healthy population. Data from healthy individuals aged 18–65, who were provided with a routine medical evaluation during 2000–2014, were retrieved from the medical charts. Individuals with background illnesses and those who had used medications or nutritional supplements were excluded. Vitamin B12 deficiency was defined by 2 cutoff values (206 and 140 pmol/L). The multivariate analysis was adjusted for age, body mass index, estimated glomerular filtration rate, hyperhomocysteinemia, folate deficiency, albumin, and transferrin saturation. Sensitivity analyses were implemented by excluding individuals with anemia, hyperhomocysteinemia, or folate deficiency and by age stratification. Results: In all, 7,963 individuals met the inclusion criteria. Serum vitamin B12 mean levels were 312.36 and 284.31 pmol/L for women and men respectively (p < 0.001). Deficiency prevalence was greater for men (25.5%) in comparison with women (18.9%; p < 0.001). Men were strongly associated with severe deficiency (adjusted OR 2.26; 95% CI 1.43–3.56). Conclusions: Among the healthy population, men are susceptible to vitamin B12 deficiency. This can be explained by neither diet habits nor estrogen effects. Genetic variations are therefore hypothesized to play a role.

show abstract

Section: Discussionmentioning

confidence: 55%

Vitamin B12 Deficiency and the Role of Gender: A Cross-Sectional Study of a Large Cohort

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The prevalence of frailty and sarcopenia in this study was found to be consistent with community-dwelling older adults in the literature. The rates of sarcopenia and frailty were reported to be 24% 7 and 26% 8 in other studies from Turkey. The prevalence of frailty varies by 30%–40% and the frequency increases with age and ethnical differences may be seen.…”

Section: Discussionmentioning

confidence: 73%

“…Both syndromes have major adverse effects on activities of daily living and quality of life; furthermore, they increase hospitalization, morbidity, mortality, and risk of falls and fracture. 7 , 8 Their pathogenesis has not been clearly elucidated and there is no diagnostic criteria that is universally accepted. Malnutrition, which is regarded as a separate syndrome, also presents as a risk factor for frailty and sarcopenia.…”

Section: Introductionmentioning

confidence: 99%

Frequency and coincidence of geriatric syndromes according to age groups: single-center experience in Turkey between 2013 and 2017

Bulut

Soysal

Işık

2018

CIA

Self Cite

View full text Add to dashboard Cite

BackgroundGeriatric syndromes are complex clinical manifestations that are not an isolated disease in older adults and have common risk factors within themselves. The syndromes are significant causes of mortality, morbidity, and increased health care costs.ObjectiveTo determine the frequency of geriatric syndromes such as malnutrition, dementia, depression, falls, polypharmacy, urinary incontinence, pressure ulcer, sarcopenia, and frailty in community-dwelling older adults.MethodsA total of 2,816 patients, who applied to geriatric outpatient clinic and were evaluated by comprehensive geriatric assessment, were included in this cross-sectional retrospective study. Falls in the last year and urinary incontinence were recorded. Polypharmacy was accepted as concurrent use of more than four drugs. Diagnosis of dementia and depression was defined according to Diagnostic and Statistical Manual of Mental Disorders Fifth Edition diagnostic criteria. In addition, frailty and sarcopenia were evaluated according to Fried’s physical frailty scale and European Working Group on Sarcopenia criteria, respectively.ResultsThe frequency of polypharmacy was 54.5%, urinary incontinence 47.6%, malnutrition 9.6%, depression 35.1%, dementia 21.6%, falls 33.6%, sarcopenia 31.7%, and frailty 28.3%. When all the participants were divided into three groups (60–69, 70–79, ≥80 years), all syndromes were significantly increased with age, except for depression. While 20% of cases in 60–69 years age group did not have any syndromes, 48% of cases in ≥80 years had more than four syndromes simultaneously.ConclusionThe frequency and coincidence of geriatric syndromes, except for depression, increases with age. Therefore, clinicians other than geriatricians taking care of older people should be aware of these syndromes as well as their treatment mechanisms.

show abstract

“…For the evaluation of walking speed, muscle strength and muscle mass in patients, 4‐m walking test, handgrip test and bioimpedance were carried out for each patient, respectively . The handgrip test was measured by a Jamar (Model J00105, Lafayette, USA) branded hand dynamometer, and bioimpedance was established by Tanita (MC‐780U Multi Frequency Segmental Body Composition, Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

Validity of the Kihon Checklist for evaluating frailty status in Turkish older adults

Esenkaya

Dokuzlar

Soysal

et al. 2019

Geriatrics Gerontology Int

Self Cite

View full text Add to dashboard Cite

Aim The Kihon Checklist (KCL) was developed to identify vulnerable older adults residing in Japan who are at a high risk of becoming dependent. The present study aimed to determine the validity of the KCL for detecting frailty in Turkish older adults. Methods A total of 300 outpatients were enrolled in the study. All patients underwent comprehensive geriatric assessment and completed a Turkish translation of the KCL. Frailty status was defined by five dimensions, including weight loss, exhaustion, low levels of activity, weakness and slowness: 0 for robust, 1–2 for prefrail and 3–5 for frail. Results The mean age of the patients was 73.85 ± 7.12 years. According to Fried definitions, 25.7% were considered frail, 48.0% prefrail and 26.3% robust. There was a significant difference between the groups in terms of age, sex, education, Charlson's Comorbidity Index, the number of medications used, sarcopenia, dynapenia and all the comprehensive geriatric assessment parameters (P < 0.05). Cronbach's α value of the KCL was 0.876. The area under the receiver operating characteristics curve was 0.855 for frail, and 0.697 for prefrail. We found that the KCL can show frail and prefrail older adults when the cut‐off values are ≥9 and ≥ 4, respectively, with a sensitivity of 80.52% and 65.28%, and specificity of 81.17% and 56.96%. Conclusions The KCL can be used as a quick, simple and sensitive screening method for detecting frailty among Turkish older adults. We recommend its use by healthcare professionals in Turkey in order to identify frail older adults and direct them to relevant support. Geriatr Gerontol Int 2019; 19: 616–621.

show abstract

Vitamin B12 deficiency might be related to sarcopenia in older adults

Cited by 78 publications

References 37 publications

Vitamin B12 Deficiency and the Role of Gender: A Cross-Sectional Study of a Large Cohort

Vitamin B12 Deficiency and the Role of Gender: A Cross-Sectional Study of a Large Cohort

Frequency and coincidence of geriatric syndromes according to age groups: single-center experience in Turkey between 2013 and 2017

Validity of the Kihon Checklist for evaluating frailty status in Turkish older adults

Contact Info

Product

Resources

About