Vitamin B12 deficiency may play an etiological role in atrophic glossitis and its grading: A clinical case-control study

Chen, Guanying; Tang, Ziyang; Bao, Zhe-Xuan

doi:10.1186/s12903-022-02464-z

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…On the other hand, metformin can increase the amount of vitamin B12 normally stored in the liver, thus leading to a change in tissue distribution and metabolism of vitamin B12 [123]. Finally, it can also modify the metabolism and reabsorption of bile acids.…”

Section: Oral Hypoglycaemic Agent-metforminmentioning

confidence: 99%

An Update on Drug–Nutrient Interactions and Dental Decay in Older Adults

Bell,

Rodrigues,

Antoniadou

et al. 2023

Nutrients

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In recent decades, the global demographic landscape has undergone a discernible shift that has been characterised by a progressive increase in the proportion of elderly individuals, indicative of an enduring global inclination toward extended lifespans. The aging process, accompanied by physiological changes and dietary patterns, contributes to detrimental deviations in micronutrient consumption. This vulnerable aging population faces heightened risks, including dental caries, due to structural and functional modifications resulting from insufficient nutritional sustenance. Factors such as physiological changes, inadequate nutrition, and the prevalence of multiple chronic pathologies leading to polypharmacy contribute to the challenge of maintaining an optimal nutritional status. This scenario increases the likelihood of drug interactions, both between medications and with nutrients and the microbiome, triggering complications such as dental decay and other pathologies. Since the drug industry is evolving and new types of food, supplements, and nutrients are being designed, there is a need for further research on the mechanisms by which drugs interfere with certain nutrients that affect homeostasis, exemplified by the prevalence of caries in the mouths of older adults. Infectious diseases, among them dental caries, exert serious impacts on the health and overall quality of life of the elderly demographic. This comprehensive review endeavours to elucidate the intricate interplay among drugs, nutrients, the microbiome, and the oral cavity environment, with the overarching objective of mitigating the potential hazards posed to both the general health and dental well-being of older adults. By scrutinising and optimising these multifaceted interactions, this examination aims to proactively minimise the susceptibility of the elderly population to a spectrum of health-related issues and the consequences associated with dental decay.

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Section: Oral Hypoglycaemic Agent-metforminmentioning

confidence: 99%

An Update on Drug–Nutrient Interactions and Dental Decay in Older Adults

Bell,

Rodrigues,

Antoniadou

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…Diffuse erythema with a smooth, atrophic dorsal surface typically represents the erythematous type of oral candidiasis. Nutrient deficiencies such as vitamin B12, folic acid, or iron deficiency cause glossitis and anemia, resulting in atrophy of the papillae on the dorsal tongue surface [ 1 , 2 ]. An atrophic tongue has also been reported to be associated with Sjögren syndrome [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of Abnormal Changes on the Dorsal Tongue Surface Using Deep Learning

et al. 2023

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Background and Objective: The tongue mucosa often changes due to various local and systemic diseases or conditions. This study aimed to investigate whether deep learning can help detect abnormal regions on the dorsal tongue surface in patients and healthy adults. Materials and Methods: The study collected 175 clinical photographic images of the dorsal tongue surface, which were divided into 7782 cropped images classified into normal, abnormal, and non-tongue regions and trained using the VGG16 deep learning model. The 80 photographic images of the entire dorsal tongue surface were used for the segmentation of abnormal regions using point mapping segmentation. Results: The F1-scores of the abnormal and normal classes were 0.960 (precision: 0.935, recall: 0.986) and 0.968 (precision: 0.987, recall: 0.950), respectively, in the prediction of the VGG16 model. As a result of evaluation using point mapping segmentation, the average F1-scores were 0.727 (precision: 0.717, recall: 0.737) and 0.645 (precision: 0.650, recall: 0.641), the average intersection of union was 0.695 and 0.590, and the average precision was 0.940 and 0.890, respectively, for abnormal and normal classes. Conclusions: The deep learning algorithm used in this study can accurately determine abnormal areas on the dorsal tongue surface, which can assist in diagnosing specific diseases or conditions of the tongue mucosa.

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Vitamin B12 deficiency may play an etiological role in atrophic glossitis and its grading: A clinical case-control study

Cited by 2 publications

References 20 publications

An Update on Drug–Nutrient Interactions and Dental Decay in Older Adults

An Update on Drug–Nutrient Interactions and Dental Decay in Older Adults

Detection of Abnormal Changes on the Dorsal Tongue Surface Using Deep Learning

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