Vitamin B12 deficiency in patients after enterocystoplasty

Keenan, Alison; Whittam, Benjamin; Rink, Richard C.; Kaefer, Martin; Misseri, Rosalie; King, Shelly; Cain, Mark P.

doi:10.1016/j.jpurol.2015.04.026

Cited by 14 publications

(4 citation statements)

References 12 publications

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“…Chez notre patient nous avons plutôt réalisé une cystectomie totale et une enterocystoplastie iléale de substitution mais avec conservation de la prostate, cette dernière n'était pas infiltrée par rapport au bilan d'extension réalisé, et une réimplantation urétérale était réalisée. Keenan dans son étude en 2015 montre que 38% des patients ont développé en post enterocystoplastie iléale le déficit en vitamine B12, anémiemégaloblastique, trouble neuropsychiatrique, neuropathie périphérique par demyelinisation [10]. Notre patient avait été soumis à une vitaminothérapie B12 et aucune complication n'avait été mise en évidence.…”

Section: Discussionunclassified

Carcinome urothélial invasif vésical récidivant traité par cystectomie avec enterocystoplastieiléale de substitution: à propos d'un cas

Kasanga¹,

Ntanga²,

Musapoudi³

et al. 2019

Pan Afr Med J

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Notre travail vise à rapporter un cas de carcinome urothelial vésical qui est une tumeur rare chez les sujets de moins de 40 ans, et apporter notre expérience thérapeutique, cela à travers l'observation d'un patient âgé de 37 ans, avec antécédent d'infection urinaire et un séjour dans une région riveraine (bilharziose) ayant consulté pour hypogastralgie et hématurie totale macroscopique. Le bilan clinique et paraclinique, mettait en évidence une volumineuse masse tumorale vésicale d'allure infiltrante, sans envahissement ganglionnaire ou organique local ou à distance. Sa prise en charge chirurgicale a consisté en une exérèse biopsique tumorale vésicale suivie d'une cystectomie totale, avec enterocystoplastie iléale de substitution. Les suites opératoires ont été simples. Il avait bénéficié également d'une chimiothérapie adjuvante et une vitaminothérapie B12. Les contrôles cliniques et paracliniques effectués 6 et 12 mois ne montraient aucune récidive.

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Section: Discussionunclassified

Carcinome urothélial invasif vésical récidivant traité par cystectomie avec enterocystoplastieiléale de substitution: à propos d'un cas

Kasanga¹,

Ntanga²,

Musapoudi³

et al. 2019

Pan Afr Med J

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“…Studies have shown that VitB12 and folic acid deficiency lead to homocysteine metabolism, and is inhibited by the role of axons and myelin in Schwann cells, leading to neuronal damage and peripheral neuropathy[ 19 ]. Another study revealed that VitB12 deficiency can lead to neuronal myelination[ 20 - 22 ]. However, at present, the relationship between these two has not been clinically confirmed.…”

Section: Discussionmentioning

confidence: 99%

Correlation between serum vitamin B12 level and peripheral neuropathy in atrophic gastritis

Yang

Zhao

Kong

et al. 2018

WJG

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AIMTo explore the correlation between serum vitamin B12 level and peripheral neuropathy in patients with chronic atrophic gastritis (CAG).METHODSA total of 593 patients diagnosed with chronic gastritis by gastroscopy and pathological examination from September 2013 to September 2016 were selected for this study. The age of these patients ranged within 18- to 75-years-old. Blood pressure, height and weight were measured in each patient, and the body mass index value was calculated. Furthermore, gastric acid, serum gastrin, serum vitamin and serum creatinine tests were performed, and peripheral nerve conduction velocity and Helicobacter pylori (H. pylori) were detected. In addition, the type of gastritis was determined by gastroscopy. The above factors were used as independent variables to analyze chronic gastritis with peripheral neuropathy and vitamin B12 deficiency risk factors, and to analyze the relationship between vitamin B12 levels and peripheral nerve conduction velocity. In addition, in the treatment of CAG on the basis of vitamin B12, patients with peripheral neuropathy were observed.RESULTSAge, H. pylori infection, CAG, vitamin B9 and vitamin B12 were risk factors for the occurrence of peripheral nerve degeneration. Furthermore, CAG and H. pylori infection were risk factors for chronic gastritis associated with vitamin B12 deficiency. Serum vitamin B12 level was positively correlated with sensory nerve conduction velocity in the tibial nerve (R = 0.463). After vitamin B12 supplementation, patients with peripheral neuropathy improved.CONCLUSIONSerum vitamin B12 levels in patients with chronic gastritis significantly decreased, and the occurrence of peripheral neuropathy had a certain correlation. CAG and H. pylori infection are risk factors for vitamin B12 deficiency and peripheral neuropathy. When treating CAG, vitamin B12 supplementation can significantly reduce peripheral nervous system lesions. Therefore, the occurrence of peripheral neuropathy associated with vitamin B12 deficiency may be considered in patients with CAG. Furthermore, the timely supplementation of vitamin B12 during the clinical treatment of CAG can reduce or prevent peripheral nervous system lesions.

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“…Fortunately, hypocobalaminemia is often asymptomatic but the potentially devastating, irreversible neurologic complications make its diagnosis and treatment essential. A review of 23 patients 6 with augmented bladders with serum B12 levels <300 pg/mL revealed no evidence of pernicious anemia at a mean of 49 months following initial abnormal B12 level (63).…”

Section: Vitamin B12 Deficiencymentioning

confidence: 99%

“…Oral replacement is generally well-tolerated and effective in increasing serum B12 levels for the short term, however, long-term oral replacement success is poor, possibly due to reduced patient compliance (62,63). Fortunately, hypocobalaminemia is often asymptomatic but the potentially devastating, irreversible neurologic complications make its diagnosis and treatment essential.…”

Section: Vitamin B12 Deficiencymentioning

confidence: 99%

Long-Term Sequela of Pediatric Bladder Reconstruction

Roth

Keenan

Cain

et al. 2015

Curr Bladder Dysfunct Rep

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Children with refractory neurogenic bladder (NGB) who have failed maximal medical management are presented with options for bladder reconstruction. It is critical to understand the long-term sequela of bladder augmentation and bladder neck reconstruction to properly counsel families regarding these procedures. Benefits may include preservation of renal function, continence, reduced risk of renal-related mortality and potential improvements in quality of life (QOL). However, these advantages must be balanced with the risks of bladder calculi, perforation, need for additional surgery, acid/base disturbances, vitamin B12 deficiency and malignancy. Therefore, careful patient selection and preoperative counseling are paramount for those undergoing bladder reconstruction which includes intestinal bladder augmentation, as these patients require lifelong vigilant follow-up. IntroductionChildren with neurogenic bladders (NGB) are initially managed with clean intermittent catheterization (CIC) and anticholinergic medications in order to maintain a sizable, continent, and compliant urinary reservoir. Despite early and aggressive intervention, some patients undergo lower urinary tract reconstruction (bladder augmentation, catheterizable channel and/or bladder neck reconstruction) to protect their upper tracts and achieve continence. In a few select patients with favorable urodynamics (UDS) and low outlet resistance, a bladder neck procedure (BNP) can be performed without bladder augmentation to achieve continence. Myelodysplasia, specifically spina bifida (SB), remains the most common etiology of NGB in the pediatric population. Due to medical advances, particularly in the realm of Urology, more SB patients with bladder reconstruction are surviving into adulthood. We review current literature regarding long-term sequela of bladder reconstruction in pediatric patients with neurogenic bladder, with a primary focus on bladder augmentations for refractory NGB secondary to SB.

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Vitamin B12 deficiency in patients after enterocystoplasty

Cited by 14 publications

References 12 publications

Carcinome urothélial invasif vésical récidivant traité par cystectomie avec enterocystoplastieiléale de substitution: à propos d'un cas

Carcinome urothélial invasif vésical récidivant traité par cystectomie avec enterocystoplastieiléale de substitution: à propos d'un cas

Correlation between serum vitamin B12 level and peripheral neuropathy in atrophic gastritis

Long-Term Sequela of Pediatric Bladder Reconstruction

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