Vitamin B12 deficiency and gastric histopathology in older patients

Abstract

Significantly different endoscopic findings and types of gastritis could often be observed in the presence and absence of B12 deficiency. Atrophy, based on endoscopy, and atrophic gastritis, based on histopathology, suggest the presence of B12 deficiency. Gastric histopathology is not influenced by the age, gender, Hct or MCV of the patients.

Micronutrients (Other than iron) and Helicobacter pylori Infection: A Systematic Review

“…Study characteristics: Of the totally 21 selected studies addressing H. pylori infection and cobalamin , 17 investigated the association between H. pylori infection and cobalamin levels (nine cross-sectional studies mainly based on clinical setting [55,58,61,62,66,[70][71][72]74] and eight case series [56,57,59,60,67,69,73,75]), and five case series addressed the effect of eradication treatment on cobalamin levels [59,[63][64][65]68]. Overall, the 17 studies addressing the association between H. pylori infection and cobalamin levels involved a total number of 2454 subjects (mean age 58 years, 57.1% women), of whom 47.8% had H. pylori infection assessed by histology in six [59][60][61][62]67,71], culture in one [59], biopsy urease testing in one [67], urea breath test in six [56,58,59,62,70,72], stool antigen test in two [70,72], and finally serology in eight studies [55][56][57]66,69,…”

“…Overall, the 17 studies addressing the association between H. pylori infection and cobalamin levels involved a total number of 2454 subjects (mean age 58 years, 57.1% women), of whom 47.8% had H. pylori infection assessed by histology in six [59][60][61][62]67,71], culture in one [59], biopsy urease testing in one [67], urea breath test in six [56,58,59,62,70,72], stool antigen test in two [70,72], and finally serology in eight studies [55][56][57]66,69,[73][74][75]. In 11 studies, only one of these diagnostic methods for H. pylori infection was used, which was histology in three [60,61,71], urea breath test in one [58], and serology in seven studies [55,57,66,69,[73][74][75]. The clinical setting of the study populations was heterogeneous including not only dyspeptic patients [60][61][62]67], cobalamin-deficient patients [56,57,59], and asymptomatic subjects [66,69,…”

“…In 11 studies, only one of these diagnostic methods for H. pylori infection was used, which was histology in three [60,61,71], urea breath test in one [58], and serology in seven studies [55,57,66,69,[73][74][75]. The clinical setting of the study populations was heterogeneous including not only dyspeptic patients [60][61][62]67], cobalamin-deficient patients [56,57,59], and asymptomatic subjects [66,69,70,73] but also patients with peripheral arterial disease [55] and type II diabetes [58], subjects with diagnosed or suspected coronary heart disease [71,74], and alcoholdependent subjects [75].…”

Randomised clinical trial: simvastatin as adjuvant therapy improves significantly the Helicobacter pylori eradication rate ‐ a placebo‐controlled study

“…Helicobacter pylori ( H. pylori ) is an important human pathogen that causes gastroduodenal inflammation resulting in diseases, such as duodenal ulcer disease, gastric ulcer disease, iron and/or vitamin B12 deficiency, gastric adenocarcinoma and primary B‐cell gastric lymphoma . Eradication of H. pylori can lead to reduction in the recurrence of peptic ulcer diseases and prevention of gastric cancer …”

The Effectiveness of Vitamin B12 for Relieving Pain in Aphthous Ulcers: A Randomized, Double-blind, Placebo-controlled Trial

“…Vitamin B12 may play an important role in the treatment of aphthous ulcers. The most common cause of vitamin B12 deficiency is food-cobalamin malabsorption resulting from gastric dysfunction (Dholakia et al, 2005). The prevalence of vitamin B12 deficiency increases with age and is highest among elderly individuals (>65 years old) (Dali-Youcef & Andr es, 2009).…”