Vitamin B12 and hepatic enzyme serum levels correlate with interleukin-6 in alcohol-dependent individuals without liver disease

Liappas, Ioannis; Nicolaou, Chryssoula; Chatzipanagiotou, Stylianos; Tzavellas, Elias; Piperi, Christina; Papageorgiou, Charalabos; Boufidou, Fotini; Bagos, Pantelis G.; Soldatos, Constantin R.

doi:10.1016/j.clinbiochem.2007.03.002

Cited by 7 publications

(3 citation statements)

References 27 publications

(34 reference statements)

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“…Similar findings have been described in studies on people with alcoholic-related liver disease and chronic hepatitis C infection [10][11][12], adding to the evidence that fibrotic/inflammatory liver disease raises the concentration of circulating vitamin B12 by depleting hepatic tissue stores. Other studies have found correlations between vitamin B12 concentrations in blood with hepatic enzymes, suggesting that the concentration of circulating vitamin B12 could be related to hepatic disease severity [27][28][29]. In line with this, a retrospective study on patients with chronic hepatitis C infection undergoing antiviral treatment found that lower vitamin B12 levels at baseline were associated with better outcomes and higher sustained viral response [12].…”

Section: Discussionmentioning

confidence: 67%

Vitamin B12 Levels, Substance Use Patterns and Clinical Characteristics among People with Severe Substance Use Disorders: A Cohort Study from Western Norway

et al. 2022

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People with severe substance use disorder (SUD) have a higher burden of micronutrient deficiency compared with the general population. The aim of this study was to investigate vitamin B12 status and risk factors of deficiency related to substance use, opioid agonist therapy (OAT), as well as hepatitis C infection and liver fibrosis. In this prospective cohort study, participants were recruited from outpatient OAT and SUD clinics in western Norway, and assessed annually with a clinical interview and exam, including venous blood sampling. Data were collected between March 2016 and June 2020, and a total of 2451 serum vitamin B12 measurements from 672 participants were included. The median serum vitamin B12 concentration was 396 (standard deviation 198) pmol/L at baseline, 22% of the population had suboptimal levels (<300 pmol/L) and 1.2% were deficient at baseline (<175 pmol/L). No clear associations were seen with substance use patterns, but liver disease and younger age were associated with higher vitamin B12 levels. Although the majority of participants had satisfactory vitamin B12 levels, about a fifth had suboptimal levels that might or might not be adequate for metabolic needs. Future studies could investigate potential gains in interventions among patients with suboptimal but non-deficient levels.

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Section: Discussionmentioning

confidence: 67%

Vitamin B12 Levels, Substance Use Patterns and Clinical Characteristics among People with Severe Substance Use Disorders: A Cohort Study from Western Norway

et al. 2022

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“…The impact of alcohol intoxication on the S100B serum level is unclear [16,23,24]. Chronic alcohol dependence can lead to higher S100B protein serum levels, and this is correlated with the amount of alcohol consumption [25]. According to Brin et al, an elevated serum level can also be an effect of acute intoxication in groups with head trauma but also among those with no trauma at all [26].…”

Section: Discussionmentioning

confidence: 99%

Significance of S100B Protein as a Rapid Diagnostic Tool in Emergency Departments for Traumatic Brain Injury Patients

Jalali,

Godlewska,

Fadrowska-Szleper

et al. 2023

JPM

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Traumatic brain injuries (TBIs) are not only the leading cause of death among people below 44 years of age, but also one of the biggest diagnostic challenges in the emergency set up. We believe that the use of serum biomarkers in diagnosis can help to improve patient care in TBI. One of them is the S100B protein, which is currently proposed as a promising diagnostic tool for TBI and its consequences. In our study, we analyzed serum biomarker S100B in 136 patients admitted to the Emergency Department of the Regional Specialist Hospital in Olsztyn. Participants were divided into three groups: patients with head trauma and alcohol intoxication, patients with head trauma with no alcohol intoxication and a control group of patients with no trauma or with injury in locations other than the head. In our study, as compared to the control group, patients with TBI had a significantly higher S100B level (both with and without intoxication). Moreover, in both groups, the mean S100B protein level was significantly higher in patients with pathological changes in CT. According to our study results, the S100B protein is a promising diagnostic tool, and we propose including its evaluation in routine regimens in patients with TBI.

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“…We didn't detect increased IL-10 in any groups in this patient population of non-viral end-stage liver disease. Some investigators have also demonstrated increased IL-8 and IL-6 in alcoholic liver disease and suggested that this can be used as a marker for such etiology [20,21]. None of these studies however, compared the levels of these markers with that in the cirrhosis of non-alcoholic etiology.…”

Section: Discussionmentioning

confidence: 99%

Identification of Serum Biomarkers in End Stage Liver Disease

Koutsogiannis¹,

Summers²,

George³

et al. 2010

TOBIOMJ

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Background: Progressive fibrosis and cirrhosis, clinically presenting as end-stage liver disease are common outcomes in alcoholic hepatitis as well as non-alcoholic fatty liver disease(NAFLD). In these processes, a series of changes occurs in liver tissues leading to cell death, remodeling, fibrosis and regeneration. The aim of this study is to identify potential novel biomarkers for non-invasive diagnosis of cirrhosis due to alcoholic etiology or NAFLD. Methods: Serum from patients with biopsy proven end-stage liver disease of various etiologies, namely NAFLD(n=9), alcohol( n=5), and other end-stage liver diseases(n=6), who underwent liver transplant during the first six months of 2007 were utilized for retrospective analysis. Serum samples were also collected from a group of healthy volunteers (n=7). The samples were analysed using Luminex technology or ELISA for 27 biomarkers that are known to be involved in pathologic processes such as cell death, regeneration and fibrosis. Results: Of the 27 serum markers examined, 16 were elevated in the serum in all groups with end-stage liver diseases compared with the control group. They include adipokines, apoptosis and inflammatory mediators and growth factors. Interestingly, the serum of NAFLD patients showed significantly elevated HGF levels and trend towards increase in sFAS, TGF􀀁1, TNFR-1, TNFR-2 and leptin. The level of serum markers showed excellent correlation with each other indicating a complex interdependent pathogenetic mechanism. Conclusions: The data from this study indicate that a large number of serum markers are altered in end-stage liver diseases. A panel of such markers may potentially be useful in assessing advanced fibrosis and cirrhosis in patients with chronic end stage liver diseases.

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Vitamin B12 and hepatic enzyme serum levels correlate with interleukin-6 in alcohol-dependent individuals without liver disease

Cited by 7 publications

References 27 publications

Vitamin B12 Levels, Substance Use Patterns and Clinical Characteristics among People with Severe Substance Use Disorders: A Cohort Study from Western Norway

Vitamin B12 Levels, Substance Use Patterns and Clinical Characteristics among People with Severe Substance Use Disorders: A Cohort Study from Western Norway

Significance of S100B Protein as a Rapid Diagnostic Tool in Emergency Departments for Traumatic Brain Injury Patients

Identification of Serum Biomarkers in End Stage Liver Disease

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