Vitamin B12 and folic acid levels in pediatric migraine patients

Aydin, Hilal; Bucak, İbrahim Hakan; Geyik, Mehmet Faruk

doi:10.1007/s13760-020-01491-3

Cited by 11 publications

(7 citation statements)

References 18 publications

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“…The mean vitamin B12 levels were found to be significantly lower both in adult and pediatric migraine patients than in healthy patients. 2 20 In our study, 55 of the 97 patients with migraine had low serum vitamin B12 levels, we think that inadequate dietary intake due to socioeconomic reasons was the most common cause of the vitamin B12 deficiency. As a preventable cause of neurological morbidity, vitamin B12 deficiency becomes critical to determine in children in developing countries like our country.…”

Section: Discussionmentioning

confidence: 56%

Hydroxocobalamin Treatment and Pediatric Migraine Disability Assessment Scale Scores

Ayça

Doğan

2022

Journal of Pediatric Neurology

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Migraine is a common neurologic disorder in children, especially in adolescents. It can affect the school performance, family, and social daily activities. The Pediatric Migraine Disability Assessment Scale (PedMIDAS) is commonly used in young patients. This study evaluated vitamin B12 deficiency in children with migraine and the effect of hydroxocobalamin treatment on PedMIDAS scores. The study group comprised patients with vitamin B12 deficiency and diagnosed migraine. The PedMIDAS questionnaire was conducted before and 3 months after hydroxocobalamin treatment. PedMIDAS scores were evaluated and compared before and after hydroxocobalamin treatment. The mean ± standard deviation of vitamin B12 level was 175.9 ± 21.3 pg/mL in children with migraine. The PedMIDAS scores were significantly lower after hydroxocobalamin treatment than before treatment (p < 0.001). These results indicated that hydroxocobalamin made a positive contribution to the mitigation of migraine symptoms in children and that treating vitamin B12 deficiency could be a useful option.

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Section: Discussionmentioning

confidence: 56%

Hydroxocobalamin Treatment and Pediatric Migraine Disability Assessment Scale Scores

Ayça

Doğan

2022

Journal of Pediatric Neurology

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“…They suggested that patients with lower levels of vitamin B 12 and higher levels of MMA had higher odds of migraine. Aydın et al (14) performed a retrospective study in children and adolescents, including 65 migraineurs and 87 healthy cases. They found a statistically significant difference between the migraine group and the control group, in terms of levels of vitamin B 12 and folic acid (p=0.008, p<0.0001).…”

Section: % CImentioning

confidence: 99%

“…Numerous neurological disorders have been reported related to vitamin B₁₂ deficiency. Moreover, studies on the relationship between headache and vitamin B₁₂ deficiency have been increasing (12)(13)(14)(15) . In the current study, we aimed to determine the relationship between vitamin B₁₂ levels, and headache types in Turkish children and adolescents.…”

Section: Introductionmentioning

confidence: 99%

Is There a Relation Between Vitamin B₁₂ Levels and Headaches in Children and Adolescents?

Ayanoğlu¹,

Tuhan²,

Komuroglu³

et al. 2021

BUCH

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Objective: Primary headaches are common and benign discomforts both in children and adolescents. However, they have a negative influence on the quality of life. This retrospective study aimed to determine the relationship between vitamin B12 results and primary headaches in Turkish children. Methods: Demographical features, headache types, laboratory results, including vitamin B12, were assessed retrospectively. Headache types were categorized as tension-type headache, migraine, and unclassified headache according to the International Classification of Headache Disorders-beta version (ICD-3 beta). Patients with seconder headaches, anemia, and macrocytosis were excluded. Results: The study group consisted of 133 (86 female, 47 male) patients with headache and a control group of 103 (57 female, 46 male) healthy children. There was no significant difference in terms of age and gender between groups (p>0.05). Vitamin B₁₂ levels in tension-type headache, migraine, and unclassified headache groups were significantly lower (p<0.0001) than in the control group. Logistic regression has identified lower vitamin B12 levels than 400 pg/ml as an independent risk factor for headache (OR: 3.212, 95% CI: 1.850-5.576). Conclusion: We conclude that lower vitamin B12 levels than 400 pg/mL may be associated with tension-type headache, migraine, and unclassified headache.

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“…Even if there are studies proving the benefit of vitamin B12 replacement in cases of migraine with aura, there is a need for more randomized controlled trials regarding migraine without aura 19 . Vitamin B12 levels were found to be low in many studies concerning pediatric and adult groups of migraineurs 12 , 20 . In those studies, no evaluation of the frequency of attacks was conducted.…”

Section: Introductionmentioning

confidence: 99%

A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine

Özek

2022

Arq. Neuro-Psiquiatr.

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Background It is believed that vitamin B12 deficiency and hyperhomocysteinemia cause endothelial cell damage by increasing the levels of free oxygen radicals, which may, in turn, be related to the onset of migraine episodes. Objective The objective of our study was to ascertain a correlation between vitamin B12 levels and migraine attack frequency and pain severity. Methods 127 patients with migraine and 45 healthy controls who presented to Okmeydanı Training and Research Hospital were included in the study. The migraine attack frequency and the duration and severity of pain in migraineurs were recorded. Pain severity was evaluated using a visual analogue scale (VAS). Vitamin B12 levels below 300 ng/L were considered low. Results The vitamin B12 levels in migraineurs were found to be significantly lower than those in the control group (227.30 ± 104.72 ng/L vs 278.44 ± 149.83 ng/L; p = 0.047). The vitamin B12 levels of patients with chronic migraine (CM) were found to be lower than those in patients with less frequent migraine attacks (197.50 ± 69.16 ng/L vs 278.56 ± 147.91 ng/L; p = 0.019). The ratio of vitamin B12 levels of 300 ng/L and above in patients with CM was lower than that of patients with episodic migraine (p < 0.05). Conclusions Along with attack frequency and pain severity assessment, it is important that migraine follow-ups should include regular measurement of vitamin B12 levels. We found lower vitamin B12 values in the CM group.

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Vitamin B12 and folic acid levels in pediatric migraine patients

Cited by 11 publications

References 18 publications

Hydroxocobalamin Treatment and Pediatric Migraine Disability Assessment Scale Scores

Hydroxocobalamin Treatment and Pediatric Migraine Disability Assessment Scale Scores

Is There a Relation Between Vitamin B₁₂ Levels and Headaches in Children and Adolescents?

A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine

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