Vitamin B12 analogues from gut microbes and diet differentially impact commensal propionate producers of the human gut
Palni Kundra,
Anna Greppi,
Monica Duppenthaler
et al.
Abstract:To produce the health-associated metabolite propionate, gut microbes require vitamin B12 as a cofactor to convert succinate to propionate. B12 is sourced in the human gut from the unabsorbed dietary fraction and in situ microbial production. However, experimental data for B12 production by gut microbes is scarce, especially on their produced B12-analogues. Further, the promotion of propionate production by microbially-produced and dietary B12 is not yet fully understood. Here, we demonstrated B12 production in… Show more
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