Vitamin B<sub>12</sub>supplementation improves rates of sustained viral response in patients chronically infected with hepatitis C virus

Rocco, Alba; Compare, Debora; Coccoli, Pietro; Esposito, Ciro; Spirito, Antimo Di; Barbato, Antonio; Strazzullo, Pasquale; Nardone, Gerardo

doi:10.1136/gutjnl-2012-302344

Cited by 34 publications

(28 citation statements)

References 22 publications

(17 reference statements)

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“…The results of IL-28B genotyping in our patients did not show any significant differences in the distribution of IL-28B genotypes (C/C, C/T and T/T) between two treatment groups, indicating that the higher rate of SVR observed in SOC + B12 patients was not affected by IL-28B genotype. Our findings were in agreement with the open-label pilot study by Rocco et al 25 , which reported that the addition of vitamin B12 to SOC significantly improved the rate of virological response in patients with chronic HCV infection. Accordingly, Rosenberg and Hagen 32 , in their work showed that high levels of vitamin B12 in serum is favorable for achieving an ETVR in CHC patients treated with SOC.…”

Section: Discussionsupporting

confidence: 93%

“…Since then, several studies have reported the correlation between vitamin B12 and virological response of chronic hepatitis C infection receiving SOC 25,32,33 . Considering these evidences, the aim of the current study was to evaluate the possible effects of adding vitamin B12 by injection (at a dose of 5000 microgram) to PegIFN and RBV combination therapy on the virological response in treatment-naive patients with chronic HCV.…”

Section: Discussionmentioning

confidence: 99%

“…Based on these evidences, the possible role of vitamin B12 supplementation in improving the rates of viral response to antiviral therapy in HCV carriers has been investigated. Recently, vitamin B12 supplementation in HCV carriers showed a significant improvement in response to treatment with PegIFN and ribavirin at all time-points during therapy 25 . However, this study was conducted on a limited number of patients and no clinical study has investigated the implication of adding B12 to SOC in the setting of HCV treatments.…”

Section: Introductionmentioning

confidence: 99%

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The efficacy of adding vitamin B12 to pegylated interferon and ribavirin treatment in Hepatitis C virus patients regarding the host and viral prognostic factors

et al. 2019

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Introduction: Hepatitis C virus (HCV) infection affects almost 180 million people around the world. Even though the development of direct acting antivirals (DAAs) has significantly improved the treatment responses to HCV infection, treatment with pegylated interferon (PegIFN) in combination with ribavirin is considered the standard of care (SOC) for chronic HCV infection treatment in countries with limited medical resources. Considering the inhibitory effect of vitamin B12 on HCV replication, we have evaluated the effect of vitamin B12 supplementation along with SOC on treatment outcomes in patients with chronic HCV infection, who were antiviral treatment-naive. Methods: In this regard, seventy-four HCV-infected patients, naïve to antiviral therapy, were randomly assigned to receive SOC or SOC in addition to vitamin B12 (SOC + B12). Viral response was evaluated at 4, 12, 24 and 48 weeks following the initiation of viral treatment and at 24 weeks after completing the treatment. Genotyping of the interleukin 28B (IL28B) polymorphisms was also performed. Demographic characteristics, clinical findings, fibroscan results and drug adverse effects were recorded. Results: Our findings showed that rapid viral response was not significantly different between the two groups; however, the rates of complete early viral response (cEVR) (p=0.033), end-of-treatment viral response (ETVR) (p=0.001) and sustained virologic response (SVR) (p=0.0001) were significantly higher in SOC + B12 patients compared to SOC patients. Besides, in SOC + B12 patients, those with a higher baseline viral load and carriers of IL28B CC genotype showed significantly higher rate of SVR. Conclusion: In conclusion, the addition of vitamin B12 significantly improved the rate of SVR in HCV-infected patients, who were naïve to antiviral therapy. As this treatment regimen is safe and inexpensive, it proposes an option for improving the effectiveness of the HCV treatment with SOC, particularly in resource-limited settings.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The efficacy of adding vitamin B12 to pegylated interferon and ribavirin treatment in Hepatitis C virus patients regarding the host and viral prognostic factors

et al. 2019

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“…Multivitamin supplementation (including vitamins B, C, and E) has been shown to be beneficial for patients with human immunodeficiency virus (HIV) 68 and tuberculosis. 69,70 Vitamin B 12 has been shown to decrease viral replication and increase sustained viral response rates in patients of hepatitis C. 71 Similarly, vitamin C supplementation has been shown to be beneficial against respiratory tract infections and pneumonia, 72 whereas selenium supplementation has been shown to reduce parasitemia and the induced organ damage in parasitic infections, such as Trypanosoma.…”

Section: Discussionmentioning

confidence: 99%

Micronutrients and Dengue

Ahmed

Finkelstein

Stewart

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Dengue virus infection is the most widespread mosquito-borne viral infection in humans and has emerged as a serious global health challenge. In the absence of effective treatment and vaccine, host factors including nutritional status, which may alter disease progression, need investigation. The interplay between nutrition and other infections is well-established, and modulation of nutritional status often presents a simple low-cost method of interrupting transmission, reducing susceptibility, and/or ameliorating disease severity. This review examines the evidence on the role of micronutrients in dengue virus infection. We found critical issues and often inconsistent results across studies; this finding along with the lack of sufficient literature in this field have limited our ability to make any recommendations. However, vitamins D and E have shown promise in small supplementation trials. In summary, the role of micronutrients in dengue virus infection is an exciting research area and needs to be examined in well-designed studies with larger samples.

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“…In addition to antiviral agents described above, vitamin B12 was also reported to act as an inhibitor of HCV replication. The use of vitamin B12 with SOC drugs raised the SVR rate to the level higher than the rate noted in patients treated with SOC alone [35] . Recently, it has been observed that vitamin D also acts against HCV in vitro.…”

Section: Other Antiviral Agentsmentioning

confidence: 81%

Molecular targeting of antiviral drugs used against hepatitis C virus infection

Irshad¹,

Gupta²,

Irshad³

2018

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Present study reports an update on the molecular interaction of antiviral drugs with viral and host cell components during hepatitis C virus (HCV) infection. In addition to the traditional therapeutic drug regimen, termed as standard of care, some recent drugs have been added in the existing regimen used for HCV infection. These drugs were categorized as direct-acting antivirals (DAAs) agents and "other agents", with their efficacious impact in the control of HCV infection. They target both viral proteases and host cell receptor proteins/enzymes involved in HCV entry into the cell, replication, and assembly to check their propagation both in situ as well as in cell to cell transmission. Recent studies have reported a significant rise in sustained virological response after the use of these drugs both alone and in combination with pegylated interferon-α (PegIFN-α) plus ribavirin. Recently, DAAs have been reported to be highly effective in eradication of HCV infection, especially liver cirrhosis, reducing but not avoiding the occurrence of liver cancer. Some studies have demonstrated that the presence of resistant HCV variants, arising during viral replication, may be controlled by the new drug regimen. It is important to note here that all these drugs are influenced by viral as well as host factors including basic viral load, HCV genotypes, IFN action, interleukin 28B polymorphism and some liver and metabolic diseases, etc. This is an area with ongoing investigations to explore more antiviral agents that may address new challenges in HCV therapy.

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Vitamin B₁₂supplementation improves rates of sustained viral response in patients chronically infected with hepatitis C virus

Abstract: Vitamin B12 supplementation significantly improves SVR rates in HCV-infected patients naïve to antiviral therapy.

Cited by 34 publications

References 22 publications

The efficacy of adding vitamin B12 to pegylated interferon and ribavirin treatment in Hepatitis C virus patients regarding the host and viral prognostic factors

The efficacy of adding vitamin B12 to pegylated interferon and ribavirin treatment in Hepatitis C virus patients regarding the host and viral prognostic factors

Micronutrients and Dengue

Molecular targeting of antiviral drugs used against hepatitis C virus infection

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Vitamin B12supplementation improves rates of sustained viral response in patients chronically infected with hepatitis C virus

Abstract: Vitamin B12 supplementation significantly improves SVR rates in HCV-infected patients naïve to antiviral therapy.

Cited by 34 publications

References 22 publications

The efficacy of adding vitamin B12 to pegylated interferon and ribavirin treatment in Hepatitis C virus patients regarding the host and viral prognostic factors

The efficacy of adding vitamin B12 to pegylated interferon and ribavirin treatment in Hepatitis C virus patients regarding the host and viral prognostic factors

Micronutrients and Dengue

Molecular targeting of antiviral drugs used against hepatitis C virus infection

Contact Info

Product

Resources

About

Vitamin B₁₂supplementation improves rates of sustained viral response in patients chronically infected with hepatitis C virus