Vitamin B<sub>12</sub>

doi:10.1002/9780470376911.ch13

Vitamins in Animal and Human Nutrition 2000

DOI: 10.1002/9780470376911.ch13

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Vitamin B₁₂

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2021

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Cited by 3 publications

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The influence of an increased cobalt supply on ruminal parameters and microbial vitamin B₁₂synthesis in the rumen of dairy cows

Stemme¹,

Lebzien²,

Flachowsky³

et al. 2008

Archives of Animal Nutrition

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The aim of the study was to examine the effects of an elevated dietary cobalt supply to dairy cows on rumen fermentation parameters and microbial vitamin B12 synthesis in the rumen. Five lactating dairy cows fitted with a ruminal and a duodenal cannula were subsequently fed either a ration containing only the native cobalt content (0.17 mg Co/ kg DM) or a ration supplemented with cobalt sulphate (0.29 mg Co/kg DM). The pH-value, the ammonia concentration as well as the concentration and the molar proportions of short chain fatty acids in the rumen were not significantly influenced by feeding the ration with the higher cobalt content. While there was no difference in microbial protein flow, the cobalamin flow at the duodenum was significantly elevated in supplemented animals (3.67 +/- 0.69 vs. 8.63 +/- 2.22 mg B12/d). The efficiency of cobalt utilisation for ruminal vitamin B12 synthesis was calculated to be 7.1 +/- 1.3% for the unsupplemented and 9.5 +/- 2.4% for the supplemented ration. Further investigation has to prove if there are any benefits for cows resulting from the elevated cobalamin synthesis measured, caused by feeding higher amounts of dietary cobalt.

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The influence of an increased cobalt supply on ruminal parameters and microbial vitamin B₁₂synthesis in the rumen of dairy cows

Stemme¹,

Lebzien²,

Flachowsky³

et al. 2008

Archives of Animal Nutrition

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The influence of an increased cobalt supply to dairy cows on the vitamin B₁₂ status of their calves

Stemme

Meyer²,

Flachowsky³

et al. 2005

Animal Physiology Nutrition

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In the experiment the influence of an elevated oral cobalt supply (Co content in the ration 0.27 mg Co/kg DM; supplement of 0.14 mg Co/kg DM as CoSO(4)) to pregnant dairy cows on the vitamin B(12) concentration in milk, colostrum and vitamin B(12) status of their calves was tested in comparison with unsupplemented controls (0.13 mg Co/kg DM). While there was no significant difference in vitamin B(12) concentration in the at 70th day of lactation (start of the experiment; 3.77 +/- 1.41 vs. 3.66 +/- 1.03 ng/ml) and 290th day of lactation (almost drying off; 4.75 +/- 3.05 vs. 4.44 +/- 0.96 ng/ml), cobalamin concentration in the milk colostrum showed a tendency towards a higher cobalt content in the ration of the supplemented cows in comparison with the controls (21.0 +/- 8.4 vs. 16.7 +/- 11.9 ng/ml). Differences in the vitamin B(12) concentration in the serum of the newborn calves before and after ingestion of colostrum were not detected. From these results it can be concluded that cobalt content of 0.13 mg Co/kg DM in the ration based on wilted grass silage seems to be sufficient for pregnant dairy cows.

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A pilot study comparing the pharmacokinetics of injectable cyanocobalamin and hydroxocobalamin associated with a trace mineral injection in cattle

Gonzalez-Rivas

Chambers²,

Liu³

2021

Vet Pharm & Therapeutics

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Injectable vitamin B12 (cobalamin) is traditionally used to prevent or treat vitamin B12 deficiencies in ruminants. Sheep and human studies have demonstrated the superiority of a single dose of hydroxocobalamin (OHB12) over cyanocobalamin (CNB12) in maintaining high levels of cobalamin in plasma and liver. However, limited data are available for cattle. The purpose of this study was to compare the pharmacokinetics of two forms of cobalamin—OHB12 and CNB12—as a single subcutaneous injection of 28 µg/kg BW at the same time of a trace mineral injection in six non‐cobalt/B12‐deficient Holstein‐Friesian steers. Plasma and liver samples were obtained to determine cobalamin concentration after treatment. Cyanocobalamin had lower retention in plasma and liver than OHB12 (p < .05). Cobalamin levels peaked in plasma by 8 h after treatment in both groups. However, OHB12 reached a higher peak compared to CNB12. Levels of cobalamin in plasma dropped closer to baseline levels 24 h after CNB12 treatment while OHB12 maintained higher concentrations. Hydroxocobalamin increased significantly hepatic concentration of cobalamin 28 days after treatment, while CNB12 did not increase liver levels relative to pre‐treatment (p < .05). These results confirm that a single subcutaneous OHB12 injection increases the level of cobalamin in the blood in the first 24 hours, and this increase is maintained in the liver for at least 28 days.

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Vitamin B₁₂

Cited by 3 publications

References 75 publications

The influence of an increased cobalt supply on ruminal parameters and microbial vitamin B₁₂synthesis in the rumen of dairy cows

The influence of an increased cobalt supply on ruminal parameters and microbial vitamin B₁₂synthesis in the rumen of dairy cows

The influence of an increased cobalt supply to dairy cows on the vitamin B₁₂ status of their calves

A pilot study comparing the pharmacokinetics of injectable cyanocobalamin and hydroxocobalamin associated with a trace mineral injection in cattle

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Vitamin B12

Cited by 3 publications

References 75 publications

The influence of an increased cobalt supply on ruminal parameters and microbial vitamin B12synthesis in the rumen of dairy cows

The influence of an increased cobalt supply on ruminal parameters and microbial vitamin B12synthesis in the rumen of dairy cows

The influence of an increased cobalt supply to dairy cows on the vitamin B12 status of their calves

A pilot study comparing the pharmacokinetics of injectable cyanocobalamin and hydroxocobalamin associated with a trace mineral injection in cattle

Contact Info

Product

Resources

About

Vitamin B₁₂

The influence of an increased cobalt supply on ruminal parameters and microbial vitamin B₁₂synthesis in the rumen of dairy cows

The influence of an increased cobalt supply on ruminal parameters and microbial vitamin B₁₂synthesis in the rumen of dairy cows

The influence of an increased cobalt supply to dairy cows on the vitamin B₁₂ status of their calves