Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy

Nix, Wilfred A.; Zirwes, Rudolf; Bangert, Volkhard; Kaiser, R; Schilling, Matthias; Hostalek, Ulrike; Obeid, Rima

doi:10.1016/j.diabres.2014.09.058

Cited by 90 publications

(77 citation statements)

References 44 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although pyridoxate and riboflavin are not related to T2D when analyzed alone, they form a module in combination with pantothenate that is significantly associated with the phenotype. This module corroborates previous observations that vitamin B levels in blood and urine are associated with T2D (Nix et al, 2015;Unoki-Kubota et al, 2010;Valdés-Ramos et al, 2015). In addition, the results indicate that not only the concentration levels in blood and urine but also exchange processes between the two fluids are linked to T2D as well.…”

Section: Application Examplesupporting

confidence: 91%

MoDentify: a tool for phenotype-driven module identification in multilevel metabolomics networks

Rasp

Kastenmueller

et al. 2018

Preprint

View full text Add to dashboard Cite

Summary: Metabolomics is an established tool to gain insights into (patho)physiological outcomes. Associations of metabolism with such outcomes are expected to span functional modules, which are defined as sets of correlating metabolites that are coordinately regulated. Moreover, these associations occur at different scales, from entire pathways to only a few metabolites, which is an aspect that has not been addressed by previous methods. Here we present MoDentify, a freely available R package to identify regulated modules in metabolomics networks at different layers of resolution. Importantly, MoDentify shows higher statistical power than classical association analysis. Moreover, the package offers direct visualization of results as interactive networks in Cytoscape. We present an application example using a complex, multifluid metabolomics dataset. Owing to its generic character, the method is widely applicable to any dataset with a phenotype variable, a data matrix, and optional pathway annotations. Availability and Implementation: MoDentify is freely available from GitHub: https://github.com/krumsiek/MoDentify The package vignette contains a detailed tutorial of the analysis workflow.

show abstract

Section: Application Examplesupporting

confidence: 91%

MoDentify: a tool for phenotype-driven module identification in multilevel metabolomics networks

Rasp

Kastenmueller

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Many patients with TD2 also present with low levels of pyridoxal-5′-phosphate (P5P), an active form of vitamin B 6 that acts as an essential cofactor for kynureninase [203,204]. Hence, this enzyme is extremely sensitive to the depletion of P5P [200], and the upregulated TRYCAT pathway, in an environment of decreased P5P, leads to an increased availability of 3-HK for 3-HK-transaminase and subsequently increased production of xanthurenic acid and 8-HQ.…”

Section: Trycats and Scfas In Type 2 Diabetesmentioning

confidence: 99%

“…Metabolic endotoxemia also plays a major role in the development of insulin resistance, metabolic syndrome, and TD2 via the activation and dysregulation of the TRYCAT pathway in the blood, immune cells, pancreas, and CNS; this produces a range of adverse effects on the synthesis, release, and performance of insulin [200]. The activation of this pathway in patients with TD2, coupled with low levels of pyridoxal-5′-phosphate, leads to chronically upregulated levels of kynurenic acid (KYNA) and xanthurenic acid and a number of other TRYCATs, all of which have a range of adverse effects on insulin production and function [201][202][203][204]. Briefly, LPS translocated into the systemic circulation provokes the synthesis of proinflammatory cytokines from antigen-presenting cells, resulting in the activation of IDO.…”

Section: Trycats and Scfas In Type 2 Diabetesmentioning

confidence: 99%

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease

Morris¹,

et al. 2016

View full text Add to dashboard Cite

There is a growing awareness that gut commensal metabolites play a major role in host physiology and indeed the pathophysiology of several illnesses. The composition of the microbiota largely determines the levels of tryptophan in the systemic circulation and hence, indirectly, the levels of serotonin in the brain. Some microbiota synthesize neurotransmitters directly, e.g., gamma-amino butyric acid, while modulating the synthesis of neurotransmitters, such as dopamine and norepinephrine, and brain-derived neurotropic factor (BDNF). The composition of the microbiota determines the levels and nature of tryptophan catabolites (TRYCATs) which in turn has profound effects on aryl hydrocarbon receptors, thereby influencing epithelial barrier integrity and the presence of an inflammatory or tolerogenic environment in the intestine and beyond. The composition of the microbiota also determines the levels and ratios of short chain fatty acids (SCFAs) such as butyrate and propionate. Butyrate is a key energy source for colonocytes. Dysbiosis leading to reduced levels of SCFAs, notably butyrate, therefore may have adverse effects on epithelial barrier integrity, energy homeostasis, and the T helper 17/regulatory/T cell balance. Moreover, dysbiosis leading to reduced butyrate levels may increase bacterial translocation into the systemic circulation. As examples, we describe the role of microbial metabolites in the pathophysiology of diabetes type 2 and autism.

show abstract

“…There were six studies that examined plasma vitamin B 12 concentrations in chronic diseases (21,26,(32)(33)(34)(35) . Vitamin B 12 concentrations were significantly lower with increasing CRP concentrations from minor to moderate to major inflammation by approximately 10 %.…”

Section: Systematic Reviewmentioning

confidence: 99%

Relationship between nutritional status and the systemic inflammatory response: micronutrients

2018

View full text Add to dashboard Cite

Micronutrients such as trace elements and vitamins are important as enzyme cofactors in the metabolism of all cells in the body and therefore key to determining nutritional status. The present systematic review examined the evidence of the impact of the systemic inflammatory response on plasma micronutrient status in acute (surgical) and chronic tissue injury. A literature review using targeted subject headings was carried out. Plasma C-reactive protein was used to classify minor (80 mg/l) inflammation. The literature search produced 2344 publications and plasma vitamin D, zinc and carotenoids were most commonly studied and plasma vitamins K, B2 and B6 were least studied. In acute injury thirteen studies (all prospective) and in chronic injury twenty-four studies (largely retrospective) were included in the review. There was consistent evidence that most common measured micronutrients in the plasma (zinc, selenium, vitamins A, D, E, K, B2, B6, B12, C, lutein, lycopene, α- and β-carotene) were significantly lowered from minor to moderate to major inflammation. The results of the present systematic review indicate that most plasma micronutrients fall as part of the systemic inflammatory response irrespective of acute or chronic injury. Therefore, in the presence of a systemic inflammation, plasma micronutrient concentrations should be interpreted with caution. There are a number of methods applied to adjust plasma micronutrient concentrations to avoid misdiagnosis of deficiency. Alternatively, intracellular measurements appear to obviate the need for such plasma adjustment to assess micronutrient status.

show abstract

Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy

Abstract: Deficiency of vitamin B₆ (PLP, pyridoxine, pyridoxal) and vitamin B₁ (thiamine) was prevalent in type 2 diabetes. Incipient nephropathy was associated with more pronounced alterations in vitamin B₆ metabolism and stronger indications of endothelial dysfunction and inflammation.

Cited by 90 publications

References 44 publications

MoDentify: a tool for phenotype-driven module identification in multilevel metabolomics networks

MoDentify: a tool for phenotype-driven module identification in multilevel metabolomics networks

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease

Relationship between nutritional status and the systemic inflammatory response: micronutrients

Contact Info

Product

Resources

About