Vitamin B&lt;sub&gt;6&lt;/sub&gt; Deficiency and Dietary Fats: Effects on Lipid Composition and Glutathione Peroxidase Activity in Rat Liver

Bordoni, Alessandra; Cabrini, Luciana; Marchetti, M.; Danesi, Francesca; Bochicchio, Davide; Biagi, Pierluigi; Maranesi, Magda

doi:10.1159/000093267

Cited by 9 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, GSH/GSSG ratio was significantly lower in vitamin B 6 deficient rats in pre-exercise. This decreased activity of antioxidant enzymes has been also reported in vitamin B 6 deficiency (Bordoni et al, 2006; Selvam & Ravichandran, 1993). Decreased GSH/GSSG ratio suggests a degraded antioxidant protection, which may have contributed to the higher exercise-induced ROS following vitamin B 6 deficient diet.…”

Section: Discussionsupporting

confidence: 74%

Effect of vitamin B6 deficiency on antioxidative status in rats with exercise-induced oxidative stress

Choi

Cho

2009

Nutr Res Pract

View full text Add to dashboard Cite

This study investigated the effect of vitamin B6 deficiency on antioxidant enzyme activities and lipid profile in rats with exercise-induced oxidative stress. Forty eight rats were fed either a vitamin B6 deficient diet (B6-) or a control diet (control) for 4 weeks and then subdivided into 3 groups: pre-exercise (PreE); post-exercise (PostE); recess after exercise (recessE). Compared to those of control group, plasma catalase and hepatic cytosol superoxide dismutase (SOD, EC 1.15.1.1) activities of B6- group were lower regardless of exercise. The ratio of reduced glutathione/oxidized glutathione (GSH/GSSG) of B6- group was lower in PreE and there was no difference between PostE and recessE. The level of malondialdehyde (MDA) of B6- was significantly higher in PreE and PostE. High-density lipoprotein-cholesterol (HDL-C) level of B6- group was lower regardless of exercise. Atherosclerotic index of B6- group was higher in PreE and there was no difference between PostE and recessE. It is suggested that a reduction in antioxidative status caused by vitamin B6 deficiency may be aggravated under exercise-induced oxidative stress.

show abstract

Section: Discussionsupporting

confidence: 74%

Effect of vitamin B6 deficiency on antioxidative status in rats with exercise-induced oxidative stress

Choi

Cho

2009

Nutr Res Pract

View full text Add to dashboard Cite

show abstract

“…B 6 acts as a cofactor and antioxidant (Chen and Xiong 2005). As previously mentioned that vitamin B 6 seemed to be associated with some defense mechanisms especially against lipid peroxidation in the tissues, this process occured when the animals are totally lacked in the vitamin B 6 in the diet (Bordoni et al 2006). Ullegaddi et al (2006) stated that the supplementation with antioxidant vitamins and B-group vitamins separately or together caused a significant reduction in the plasma MDA concentration in the subjects in contrast to the increase seen in the control group.…”

Section: Discussionmentioning

confidence: 96%

The effect of melatonin and/or complex vitamin B1,B6,B12 in modulating epinephrine-induced stress in male rats

EL-Toweissy

Mohamed

Abdel-Wahab

2013

Braz. arch. biol. technol.

View full text Add to dashboard Cite

This study was undertaken to determine the modulating effects of intramuscular administration of melatonin (MT)(1mg / kg) and/or Tri-B (B 1 , B 6 and B 12 ) (20mg/kg) on body weight and some biochemical changes in rats induced by Epinephrine (Epi) injection. The data showed that MT and/or Tri-B treatment effectively improved the changes in malondialdehyde, lipid profile, blood sugar level and insulin. MT and/or Tri-B administration following Epi improved partially the decrease in body weight and liver glycogen levels. Tri B injection following Epi partialy improved all the tested parameters except malondialdehyde and blood sugar level that completely improved in stressed rats. It was evident that a combination of MT and vitamin B complex had protective actions and further it

show abstract

“…Thus, VitB6 is required for biosynthesis and metabolism of proteins, carbohydrates, lipids, and a great diversity of further relevant bioactive substances. 1–4 Plasma reference values for humans range from 23 to 223 nmol/l. 5…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, there is evidence that VitB6 deficiency is associated with alterations in lipid and phospholipid metabolism. 4,20–24 In particular, insufficient synthesis of phosphatidylcholine (PC) contributes to hepatic impairment by triacylglyceride (TAG) accumulation via decreased secretion of lipoproteins (VLDL). 25,26 VitB6-dependent restriction of liver function is of central impact in the early phase of development.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B6 deficiency in new born rats affects hepatic cardiolipin composition and oxidative phosphorylation

Wolke

Gürtler

Peter

et al. 2019

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Vitamin B6 deficiency during pregnancy translates into a severe vitamin B6 deficiency (plasma levels decreased by 97%) in new-born rats. Further, hallmarks are increased (+89%) concentrations of homocysteine, gross changes in gene methylation and expression, and metabolic alterations including lipid metabolism. This study focuses on determining the effects of vitamin B6-deficiency on cardiolipin composition and oxidative phosphorylation in liver. For this purpose, hepatic cardiolipin composition was analyzed by means of LC/MS/MS, and mitochondrial oxygen consumption was determined by using a Clark-type electrode in a rat model of vitamin B6 deficiency. Liver mitochondria from new-born rats with pre-term vitamin B6 deficiency responded with substantial alterations in cardiolipin composition that include the following changes in the amounts of cardiolipin incorporated fatty acids: increase in C16, decrease in C18, decrease in saturated fatty acid, as well as increase in amount of oxidized cardiolipin species. These changes were accompanied by significantly decreased capacity of oxidative phosphorylation. In conclusion, vitamin B6 deficiency in new born rats induces massive alterations of cardiolipin composition and function of liver mitochondria. These findings support the importance of sufficient periconceptional supply of vitamin B6 to prevent vitamin B6 deficiency. Impact statement Vitamin B6 (VitB6) is an active co-enzyme for more than 150 enzymes and is required for a great diversity of biosynthesis and metabolic reactions. There is an increased need for VitB6 during pregnancy and sufficient supply of VitB6 is crucial for the prevention of cleft palate and neural tube defects. We show that liver mitochondria from new-born rats with pre-term VitB6 deficiency respond with substantial alterations in cardiolipin (CL) composition and in the amount of oxidized CL species. These changes are associated with a decrease in the efficiency of oxidative phosphorylation. The results of this study support the significance of sufficient supply of VitB6 during pregnancy (and periconceptional) for diminishing the number of early abortions and minimizing malformation. The established link between VitB6 deficiency, CL composition, and mitochondrial respiration/energy production provides mechanistic insight as to how the VitB6 deficiency translates into the known pathophysiological and clinically relevant conditions.

show abstract

Vitamin B<sub>6</sub> Deficiency and Dietary Fats: Effects on Lipid Composition and Glutathione Peroxidase Activity in Rat Liver

Cited by 9 publications

References 41 publications

Effect of vitamin B6 deficiency on antioxidative status in rats with exercise-induced oxidative stress

Effect of vitamin B6 deficiency on antioxidative status in rats with exercise-induced oxidative stress

The effect of melatonin and/or complex vitamin B1,B6,B12 in modulating epinephrine-induced stress in male rats

Vitamin B6 deficiency in new born rats affects hepatic cardiolipin composition and oxidative phosphorylation

Contact Info

Product

Resources

About