Vitamin B intake and status in healthy Havanan men, 2 years after the Cuban neuropathy epidemic

Arnaud, Josiane; Fleites-Mestre, P; Chassagne, Michelle; Verdura, T; Garcia, Isabelle; Hernandez-Fernandez, T; Gautier, H.; Favier, Alain; Perez-Cristia, R.; Barnouin, Jacques

doi:10.1079/bjn2001362

Cited by 27 publications

(34 citation statements)

References 21 publications

(39 reference statements)

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“…2) [11-27]. So, for studies in the range 152–662 µg/day, doubling of a folate intake resulted in an increase in serum/plasma folate by 2 β or 22% (2 0.29 = 1.22).…”

Section: Resultsmentioning

confidence: 99%

“…A consensus on the judgments was reached following discussion of each study. Thirteen studies [12, 15, 17, 19-25, 27, 30, 31] were judged at adequate risk of bias, 6 studies [14, 16, 18, 26, 29, 32, 34] were judged at a moderate risk of bias, and 4 studies was judged at a high risk of bias [11, 13, 28, 33]. …”

Section: Methodsmentioning

confidence: 99%

“…The criteria for judging these indicators were adapted from the Cochrane Library [10]. Table 3 presents the characteristics of the included studies [11-34]. …”

Section: Methodsmentioning

confidence: 99%

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Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

et al. 2018

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Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.

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“…2) [11-27]. So, for studies in the range 152–662 µg/day, doubling of a folate intake resulted in an increase in serum/plasma folate by 2 β or 22% (2 0.29 = 1.22).…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

et al. 2018

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“…26 Among adult women, there was a wide range of rates of folate deficiency, from 0% to 43% in Mexico (< 6.1 nmol/L), 22,27,28 Cuba (< 9 nmol/L), 29 and Chile (< 3.2 nmol/L). 30 Among adults, there was a large range of rates of folate deficiency, from 0% to 80% in Mexico (< 6.1 nmol/L), 22 Cuba (< 7 nmol/L) 31 , and Peru (stated as < 3.5 ng/mL). 32 Rates of folate deficiency in the elderly were reported to be 9%, 13%, 31%, and 39% in Guatemala, 33 Venezuela, 34 Ecuador, 35 and Chile, 36 respectively.…”

Section: Resultsmentioning

confidence: 99%

Folate and Vitamin B₁₂Status in Latin America and the Caribbean

et al. 2015

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Background: The current magnitude of folate and vitamin B 12 deficiency in Latin America and the Caribbean is uncertain. Objective: To summarize data on plasma or serum vitamin B 12 and folate concentrations in Latin America and the Caribbean reported since 1990, a period that covers the era before and after the introduction of folic acid fortification. Methods: A systematic review was conducted in 2012 and updated in 2014. Studies and surveys using biochemical biomarkers and conducted in apparently healthy individuals were identified. Results: Folate deficiency in Latin America and the Caribbean appears not to be a public health problem (prevalence < 5%) after the introduction of folic acid fortification. However, there is some indication that high rates of low or marginal vitamin B 12 status remain in most locations and across population groups. Conclusions: Adding vitamin B 12 as a fortificant with folic acid may be the best strategy in areas where vitamin B 12 deficiency is an established concern.

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“…In nationally representative studies conducted in Argentina (8) , Chile (9) , Costa Rica (10) , Venezuela (11) and Mexico (12,13) , the prevalence of vitamin B 12 deficiency was, respectively, 3·4-4·7 %, 8·5 %, 5·3 %, 11·4 % and 25-30 %. High prevalences of deficiency, ranging from 13 % to 82 %, were reported in non-nationally representative studies conducted in Cuba (14) and Guatemala (15,16) .…”

mentioning

confidence: 99%

Vitamin B₁₂serostatus in Colombian children and adult women: results from a nationally representative survey

Herrán

Ward

Villamor

2014

Public Health Nutr.

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Objective: Vitamin B 12 deficiency is associated with many adverse health outcomes and is highly prevalent worldwide. The present study assesses the prevalence of vitamin B 12 deficiency and marginal deficiency in Colombian children and women and examines the sociodemographic correlates of serum vitamin B 12 concentrations in these groups. Design: Cross-sectional, nationally representative survey. Setting: Colombia. Subjects: Children <18 years old (n 7243), pregnant women (n 1781), and nonpregnant women 18-49 years old (n 499). Results: The overall prevalence of vitamin B 12 deficiency (serum vitamin B 12 <148 pmol/l) and marginal deficiency (serum vitamin B 12 = 148-221 pmol/l) was, respectively, 6·6 % (95 % CI 5·2 %, 8·3 %) and 22·5 % (95 % CI 21·1 %, 23·9 %). Pregnant women had the highest prevalence of deficiency (18·9 %; 95 % CI 16·6 %, 21·5 %) compared with non-pregnant adult women (18·5 %; 95 % CI 4·4 %, 53·1 %) and children (2·8 %; 95 % CI 2·3 % %, 3·3 %). In multivariable analyses among children, mean serum vitamin B 12 was positively associated with female sex (12 pmol/l higher compared with males; P = 0·004), secondary or higher education of the household head (12 pmol/l higher compared with primary or less; P = 0·009) and food security (21 pmol/l higher compared with severe food insecurity; P = 0·003). In multivariable analyses among pregnant women, mean serum vitamin B 12 was positively associated with education of the household head and inversely associated with living in the National territories, Eastern or Pacific regions. Conclusions: The prevalence of vitamin B 12 deficiency and marginal deficiency in Colombian women and children is substantial. The burden falls largely on adult women, those with lowest education and those living in the poorest, most rural regions of the country. Keywords Vitamin B 12Deficiency Prevalence Representative survey ColombiaVitamin B 12 plays an important role in neurocognitive development and function (1) , and its deficiency has been associated with a number of poor health outcomes including anaemia, congenital malformations, neurological deficits and hyperhomocysteinaemia (2)(3)(4)(5) . Animal foods, fortified foods and supplements are the main sources of vitamin B 12 . Consequently, vitamin B 12 deficiency may be more prevalent in vegetarians, vegans, and people living in low-income communities where they may have limited purchasing power to acquire animal food sources or may not have access to fortified foods or supplements.Some studies suggest that vitamin B 12 deficiency and marginal deficiency are highly prevalent worldwide (6) . In the few countries where nationally representative data exist, the prevalence of vitamin B 12 deficiency (serum vitamin B 12 < 130 to <150 pmol/l) ranges from 11 % to 15 % in women from Germany, the UK (6) and Vietnam (7) , to 31 % among elderly from the UK. Regional surveys found vitamin B 12 deficiency in 49 % of adults in India, 40 % of children in Kenya, 28 % of pregnant women in Nepal and 20 % of women in New Zealand ...

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Vitamin B intake and status in healthy Havanan men, 2 years after the Cuban neuropathy epidemic

Cited by 27 publications

References 21 publications

Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

Folate and Vitamin B₁₂Status in Latin America and the Caribbean

Vitamin B₁₂serostatus in Colombian children and adult women: results from a nationally representative survey

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Vitamin B intake and status in healthy Havanan men, 2 years after the Cuban neuropathy epidemic

Cited by 27 publications

References 21 publications

Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

Folate and Vitamin B12Status in Latin America and the Caribbean

Vitamin B12serostatus in Colombian children and adult women: results from a nationally representative survey

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Product

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Folate and Vitamin B₁₂Status in Latin America and the Caribbean

Vitamin B₁₂serostatus in Colombian children and adult women: results from a nationally representative survey