Vitamin B Complex Deficiency After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy—a Systematic Review and Meta-Analysis

Nunes, Rita; Santos‐Sousa, Hugo; Vieira, Sofia; Nogueiro, Jorge; Bouça‐Machado, Raquel; Pereira, André; Carneiro, Silvestre; Costa-Pinho, André; Lima-da-Costa, Eduardo; Preto, John; group, C. R. I.-O.

doi:10.1007/s11695-021-05783-2

Cited by 9 publications

(6 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bei anhaltender Übelkeit mit Erbrechen sollte jedenfalls eine neurologische Abklärung erfolgen und an einen Vitamin‑B 1 -Mangel gedacht werden. Bei einem ausgeprägten Mangel kann sich eine neurologische Symptomatik mit Enzephalopathie, Ataxie und Okulomotorius-Dysfunktion (Wernicke-Enzephalopathie) entwickeln [ 16 – 18 ]. Daher wird eine Prophylaxe mit mindestens 12 mg Thiamin täglich empfohlen, am besten in Form von ausreichend dosierten Vitamin-B-Komplex-Präparaten.…”

Section: Versorgung Mit Mikronährstoffenunclassified

See 1 more Smart Citation

Postoperatives Management

Parzer,

Resl,

Stechemesser

et al. 2023

Wien Klin Wochenschr

View full text Add to dashboard Cite

ZusammenfassungDie bariatrische Chirurgie führt zu einem signifikanten Gewichtsverlust, einer Reduktion oder gar Remission einer Vielzahl an Adipositas-assoziierten Begleiterkrankungen, einer Reduktion der Mortalität und einer Verbesserung der Lebensqualität vieler PatientInnen. Dennoch ist Adipositas eine chronische Erkrankung, die auch nach bariatrischer Operation eine Weiterbetreuung erforderlich macht. Zudem können kurz- oder langfristig spezifische Probleme auftreten, wie beispielsweise Mangelzustände verschiedener Mikronährstoffe und damit assoziierte Komplikationen. Bauchschmerzen sind ein immer ernst zu nehmendes Symptom nach bariatrischen Operationen. Ein weiteres Augenmerk sollte auf der Diagnose und Behandlung des Dumping-Syndroms liegen. Personen mit Typ-2-Diabetes sollen auch bei substanziell verbesserter bzw. normalisierter Glykämie regelmäßig auf wiederkehrende Hyperglykämie und spezifische Folgeerkrankungen gescreent werden. Neben spezialisierten Zentren mit multidisziplinären Teams wird der Primärversorgung und hier insbesondere ÄrztInnen für Allgemeinmedizin eine zunehmend wichtige Rolle in der Nachsorge nach bariatrischen Operationen zukommen.

show abstract

Section: Versorgung Mit Mikronährstoffenunclassified

“…Vitamin B 12 . Während präoperativ die Prävalenz eines Vitamin‑B 12 -Mangels bereits mit bis zu 18 % angegeben wird [ 7 ], steigt diese je nach Operationsmethode auf bis zu 30 % und mehr nach RYGB [ 18 ]. Die klassische Folge eines Vitamin‑B 12 -Mangels ist eine hyperchrome makrozytäre (perniziöse) Anämie.…”

Section: Versorgung Mit Mikronährstoffenunclassified

Postoperatives Management

Parzer,

Resl,

Stechemesser

et al. 2023

Wien Klin Wochenschr

View full text Add to dashboard Cite

show abstract

“…Most studies on nutritional deficiencies after gastric bypass examine deficiencies of vitamin B 12 , vitamin B 9 , vitamin D, calcium and iron 4–12. For instance, one systematic review and meta-analysis of 46 studies found folate and B 12 as the most prevalent deficiencies with their longest follow-up being 6 years after RYGB surgery 5. However, some studies have investigated other micronutrient deficiencies such as vitamin A, vitamin E, selenium and zinc 13–15.…”

Section: Introductionmentioning

confidence: 99%

Multiple micronutrient deficiencies as a long-term complication of bariatric surgery

Dixit,

Rodriguez,

Naumann

et al. 2023

BMJ Case Rep

View full text Add to dashboard Cite

Micronutrient deficiencies may develop as a long-term complication of bariatric surgery due to alteration of gut anatomy and disruption of normal gut absorption. Inadequate repletion of essential vitamin and mineral deficiencies can lead to multisystem dysfunction. We present a case of a woman in her 50s, with a history of Roux-en-Y gastric bypass over 10 years ago, who presented with generalised weakness and a diffuse desquamating rash. A punch biopsy performed was compatible with nutritional deficiency. Labs revealed low levels of micronutrients A, B1, B6, C, E, zinc and copper. The patient received intravenous micronutrients and an oral regimen, which improved her symptoms. Unfortunately, the patient died from cardiac arrest secondary to pulmonary oedema. This report highlights the importance of high suspicion of micronutrient deficiency in patients with a history of bariatric surgery and maintaining lifelong nutritional follow-up.

show abstract

“…While SG is primarily considered a restrictive procedure, the reduction in gastric acid production and intrinsic factor secretion due to removal of a large part of the stomach may also affect absorption of micronutrients [2]. Contrary to initial belief, similar rates of long-term nutritional deficiencies are found in SG patients when compared to patients that have undergone Roux-en-Y gastric bypass, even though the intestinal surface area remains intact following SG [3][4][5][6]. Micronutrient deficiencies for vitamin D, vitamin B12, and iron as well as elevated parathyroid hormone (PTH) levels have been reported up to 5 years after SG [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Nutritional Deficiencies 3 Years After Sleeve Gastrectomy Can Be Limited by a Specialized Multivitamin Supplement

et al. 2022

View full text Add to dashboard Cite

Purpose Lifelong daily multivitamin supplementation is highly recommended after sleeve gastrectomy (SG). Based on previous research, a specialized multivitamin supplement (MVS) for SG patients was developed and optimized (WLS Optimum 1.0 and 2.0). This study presents its mid-term effectives and compares micronutrient status of SG patients using this specialized MVS to users of standard MVS (sMVS) and non-users of multivitamin supplementation during the first three years post-surgery. Materials and Methods Of the 226 participants that were included at baseline, yearly follow-up blood tests were completed by 193 participants (85%) at 12 months, 176 participants (78%) at 24 months, and 140 participants (62%) at 36 months of follow-up. At each time point, participants were divided into four groups: (1) Optimum 1.0, (2) Optimum 2.0, (3) sMVS, and (4) non-users. Serum concentrations (linear mixed-effects models) and the prevalence of micronutrient deficiencies (chi-square tests) during follow-up were compared between the groups. Results Users of specialized MVS (Optimum 1.0 and 2.0) had higher serum concentrations of hemoglobin, folic acid, and vitamin D compared to sMVS users and non-users during follow-up. Serum concentrations of vitamin B12 and (corrected) calcium were also higher in specialized MVS users than in non-users. Overall, fewer deficiencies for folic acid and vitamin D were observed in the Optimum groups. Conclusion Although the perfect multivitamin supplement for all SG patients does not exist, WLS Optimum was more effective in sustaining normal serum concentrations than standard, over-the-counter supplementation. Non-users of MVS presented with most micronutrient deficiencies and will evidently develop poor nutritional status on the longer term. Graphical abstract

show abstract

Vitamin B Complex Deficiency After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy—a Systematic Review and Meta-Analysis

Cited by 9 publications

References 55 publications

Postoperatives Management

Postoperatives Management

Multiple micronutrient deficiencies as a long-term complication of bariatric surgery

Nutritional Deficiencies 3 Years After Sleeve Gastrectomy Can Be Limited by a Specialized Multivitamin Supplement

Contact Info

Product

Resources

About