Vitamin B complex attenuated heat hyperalgesia following infraorbital nerve constriction in rats and reduced capsaicin in vivo and in vitro effects

Kopruszinski, Caroline Machado; Reis, Renata Cristiane dos; Bressan, Elisângela; Reeh, Peter W.

doi:10.1016/j.ejphar.2015.05.063

Cited by 16 publications

(3 citation statements)

References 39 publications

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“…Most recent studies suggested administration of vitamin B complex (i.e., B1, B6 and B12) alone or combined as treatment for controlling acute and chronic neuropathic pain following temporary spinal cord ischaemia and CCI-IoN in rats ( Yu et al., 2014 ; Kopruszinski et al., 2015 ). As demonstrated in this study, VBC could ameliorate the allodynic behavior in CCI-IoN rat model of orofacial pain.…”

Section: Discussionmentioning

confidence: 99%

“…The vitamins B complex, thiamine, pyridoxine and cyanocobalamin (B1, B6 and B12, respectively) were purchased from Alfa Aesar (Tewksbury, MA, United States), dissolved in sterile 0.9% sodium chloride solution (saline) just before use in doses of 180/180/1.8 mg/ml (subcutaneous - s.c.). The doses of vitamins B were chosen based on literature study ( Kopruszinski et al., 2015 ). The vitamins B were administered immediately after CCI-IoN surgery (day 0), then on days 3, 9, 15 and 21 during the treatment, totaling 5 applications.…”

Section: Methodsmentioning

confidence: 99%

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Photobiomodulation and B vitamins administration produces antinociception in an orofacial pain model through the modulation of glial cells and cytokines expression

Martins

Marques

Venega

et al. 2020

Brain, Behavior, & Immunity - Health

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Chronic constriction injury (CCI) of infraorbital nerve (IoN) results in whisker pad mechanical allodynia in rats and activation glial cells contributing to the development of orofacial pain. Whisker pad mechanical allodynia (von Frey stimuli) was tested pre and postoperatively and conducted during the treatment time. Photobiomodulation (PBM) and vitamins B complex (VBC) has been demonstrated therapeutic efficacy in ameliorate neuropathic pain. The aim of this study was to evaluate the antinociceptive effect of PBM, VBC or the combined treatment VBC + PBM on orofacial pain due to CCI-IoN. Behavioral and molecular approaches were used to analyses nociception, cellular and neurochemical alterations. CCI-IoN caused mechanical allodynia and cellular alterations including increased expression of glial fibrillary acid protein (GFAP) and ionized calcium binding adaptor molecule 1 (Iba-1), administration of VBC (B1/B6/B12 at 180/180/1.8 mg/kg, s.c., 5 times all long 10 sessions) and PBM therapy (904 nm, power of 75Wpico, average power of 0.0434 W, pulse frequency of 9500 Hz, area of the beam 0.13 cm 2 , 18 s duration, energy density 6 J/cm 2 , with an energy per point of 0.78 J for 10 sessions) or their combination presented improvement of the nociceptive behavior and decreased expression of GFAP and Iba-1. Additionally, CCI-IoN rats exhibited an upregulation of IL1β, IL6 and TNF-α expression and all treatments prevented this upregulation and also increased IL10 expression. Overall, the present results highlight the pain reliever effect of VBC or PBM alone or in combination, through the modulation of glial cells and cytokines expression in the spinal trigeminal nucleus of rats.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Photobiomodulation and B vitamins administration produces antinociception in an orofacial pain model through the modulation of glial cells and cytokines expression

Martins

Marques

Venega

et al. 2020

Brain, Behavior, & Immunity - Health

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“…In Vivo studies, vitamin B1-6-12 or vitamin B12 exhibited beneficial for accelerated nerve regeneration in injury of sciatic nerve (37,38), spinal cord (39), infraorbital nerve (40), corneal nerve (41) or optic nerve (42).Vitamin B1-6-12 and B12 has been common used for treat the NSD of IAN injury from orthognathic surgery or BSSRO. At present, few studies reported about effect of vitamin B in BSSRO.…”

Section: Many Interventions Are Used To Promote Neurosensory Recoverymentioning

confidence: 99%

Comparative study between vitamin B 1-6-12 and vitamin B 12 for neurosensory recovery after bilateral sagittal split ramus osteotomy

Trising

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A�major complication from Bilateral Sagittal Split Ramus Osteotomy (BSSRO) is�inferior alveolar nerve�injured�that manifest as neurosensory disturbance (NSD) on the lower lip, chin.�Although the NSD is not a life-threatening problem but it�impacts the patient's�daily life.�Vitamin B is commonly used to treat peripheral neuropathy but it is only few study�for NSD from BSSRO. The aim of this study was to evaluate the effect of oral vitamin B1-6-12 and vitamin B12 on NSD after�BSSRO. The study design�was�as a randomized, single�blinded control trial of 75 patients who were NSD from BSSRO (n=25). The first group was vitamin B1-6-12 group that taking�1 tablet 3�times daily. The second group was vitamin B12 group that taking 1 tablet 3 times daily.�The third group was the control group without taking vitamin B. Clinical Neurosensory Testing (CNT) was performed with static two-point discrimination, moving two-point discrimination, light touch and pinprick at preoperation, immediate, 1 week, 1 month, 3 months and 6 months and converted to Global Sensitivity Score (GSS). GSS was calculated to recovery proportion and was analysed with Friedman test and post hoc analysis with Wilcoxon signed rank test for intragroup comparison on the passing time and Kruskal Wallis H test�and post hoc with Mann Whitney U test were used for intergroup comparison. Results showed significantly increasing recovery improvement in all groups on the passing time (p<0.05). Vitamin B1-6-12 orally were significantly highest recovery proportion when comparing with�and control vitamin B12 at 6 months (p=0.038, p=0.033).�

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Enhancing nerve regeneration in infraorbital nerve injury rat model: effects of vitamin B complex and photobiomodulation

Martins,

Marques,

Chacur

2024

Lasers Med Sci

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Vitamin B complex attenuated heat hyperalgesia following infraorbital nerve constriction in rats and reduced capsaicin in vivo and in vitro effects

Cited by 16 publications

References 39 publications

Photobiomodulation and B vitamins administration produces antinociception in an orofacial pain model through the modulation of glial cells and cytokines expression

Photobiomodulation and B vitamins administration produces antinociception in an orofacial pain model through the modulation of glial cells and cytokines expression

Comparative study between vitamin B 1-6-12 and vitamin B 12 for neurosensory recovery after bilateral sagittal split ramus osteotomy

Enhancing nerve regeneration in infraorbital nerve injury rat model: effects of vitamin B complex and photobiomodulation

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