Vitamin B and its derivatives for diabetic kidney disease

Raval, Amit D.; Thakker, D.; Rangoonwala, Arohi N; Gor, Deval; Walia, Rama

doi:10.1002/14651858.cd009403.pub2

Cited by 22 publications

(17 citation statements)

References 107 publications

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“…The majority of patients with CKD can develop vitamin B6 deficiency from many causes [ 33 ]. Abnormal vitamin B6 level has been reported to be associated with diabetic kidney disease [ 34 ], kidney stones [ 35 ], and kidney cancer [ 36 ]. Skrypnyk et al found that treatment with pyridoxamine, a structural analog of vitamin B6, reduced short- and long-term injury, fibrosis, and renal functional recovery after ischemia-reperfusion AKI [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Untargeted Metabolomics Reveals the Protective Effect of a Traditional Chinese Herbal Decoction on Cisplatin‐Induced Acute Kidney Injury

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Our previous studies have demonstrated that Jian-Pi-Yi-Shen formula (JPYSF), a traditional Chinese herbal decoction, has a renoprotective effect in 5/6 nephrectomy-induced chronic kidney injury. However, the role and potential mechanisms of JPYSF in the treatment of acute kidney injury (AKI) remain unknown. This study was designed to test the beneficial effect of JPYSF in an AKI mouse model and to investigate the underlying mechanism by using metabolomics analysis. The AKI mouse model was induced by a single intraperitoneal injection of cisplatin at a dose of 20 mg/kg. The mice in the treatment group were pretreated orally with JPYSF (18.35 g/kg/d) for 5 days before cisplatin injection. Seventy-two hours after cisplatin injection, serum and kidney samples were collected for biochemical and histological examination. Ultra-high-performance liquid chromatography coupled with quadrupole time-of-ﬂight mass spectrometry (UHPLC-QTOF/MS) was applied to analyze metabolic profiling variations in the kidney. The results showed that pretreatment with JPYSF obviously reduced the levels of serum creatinine and blood urea nitrogen and alleviated renal pathological injury in AKI mice. Orthogonal partial least-squares discriminant analysis (OPLS-DA) score plot revealed a clear separation between the AKI and AKI + JPYSF group. A total of 68 and 87 significantly differentially expressed metabolites were identified in the kidney of AKI mice responding to JPYSF treatment in negative and positive ion mode, respectively. The pivotal pathways affected by JPYSF included vitamin B6 metabolism, alanine, aspartate and glutamate metabolism, lysine biosynthesis, and butanoate metabolism. In conclusion, JPYSF can protect the kidney from cisplatin-induced AKI, which may be associated with regulating renal metabolic disorders.

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Section: Discussionmentioning

confidence: 99%

Untargeted Metabolomics Reveals the Protective Effect of a Traditional Chinese Herbal Decoction on Cisplatin‐Induced Acute Kidney Injury

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…In addition, as data on medications and supplements consumption was self-reported, a reporting bias might exist, that is, individuals could potentially avoid disclosing their real intake. However, such a bias is expected to be insignificant, as the reporting bias for group B vitamin consumption, was shown to be generally low [41]. …”

Section: Discussionmentioning

confidence: 99%

Vitamin B12 Deficiency and the Role of Gender: A Cross-Sectional Study of a Large Cohort

et al. 2018

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Background: Vitamin B12 deficiency is associated with hematological, neurological, and cardiovascular consequences. Epidemiologic data on these related illnesses indicate gender differences. Methods: A cross-sectional study was designed to examine gender differences in vitamin B12 deficiency among a healthy population. Data from healthy individuals aged 18–65, who were provided with a routine medical evaluation during 2000–2014, were retrieved from the medical charts. Individuals with background illnesses and those who had used medications or nutritional supplements were excluded. Vitamin B12 deficiency was defined by 2 cutoff values (206 and 140 pmol/L). The multivariate analysis was adjusted for age, body mass index, estimated glomerular filtration rate, hyperhomocysteinemia, folate deficiency, albumin, and transferrin saturation. Sensitivity analyses were implemented by excluding individuals with anemia, hyperhomocysteinemia, or folate deficiency and by age stratification. Results: In all, 7,963 individuals met the inclusion criteria. Serum vitamin B12 mean levels were 312.36 and 284.31 pmol/L for women and men respectively (p < 0.001). Deficiency prevalence was greater for men (25.5%) in comparison with women (18.9%; p < 0.001). Men were strongly associated with severe deficiency (adjusted OR 2.26; 95% CI 1.43–3.56). Conclusions: Among the healthy population, men are susceptible to vitamin B12 deficiency. This can be explained by neither diet habits nor estrogen effects. Genetic variations are therefore hypothesized to play a role.

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“…Several studies have reported potential therapeutic applications for thiamine in treating diabetic complications (Raval et al, 2015;Kohda et al, 2008Kohda et al, , 2009Kohda et al, , 2010Kohda et al, , 2012aTanaka et al, 2010). In vitro studies have demonstrated that thiamine decreases apoptosis induced by high glucose conditioned extracellular matrix in human retinal pericytes, and a pilot study supported the use of highdose thiamine as a potential treatment for end-stage diabetic nephropathy (Rabbani et al, 2009;Beltramo et al, 2009).…”

Section: Introductionmentioning

confidence: 98%

Hepatic glucose-dependent insulinotropic polypeptide expression is modified by supplementing high-dose thiamine in obese diabetic rats

Kohda¹,

Maekita²,

Tanaka³

et al. 2017

Fundam. Toxicol. Sci.

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-Glucose toxicity and lipotoxicity are important states in obesity and diabetes. We previously reported that thiamine supplementation decreases body weight and visceral fat mass in rats with obesity-related diabetes. Glucose-dependent insulinotropic polypeptide (GIP) acts on pancreatic β cells to promote insulin secretion. According to established theory, GIP is derived from the gastrointestinal tract. We previously discovered increased expression of the GIP gene in the livers of obese rats with diabetes receiving high-dose thiamine. We referred to our previous dataset of gene expression analysis using a microarray for livers, which led to the new idea for the present study. We focused on "liver-derived GIP" to demonstrate GIP protein expression in the liver and visually present localization of GIP in the liver. Four-week-old male Otsuka Long-Evans Tokushima Fatty (OLETF) rats were randomly divided into two groups: an unsupplemented control group and a thiamine-supplemented group receiving 2 g of thiamine/L in drinking water for 51 weeks. GIP protein expression in the livers of OLETF rats at 55 weeks of age were determined by western blotting and immunohistochemical analysis. GIP protein expression in the liver was increased in thiamine-supplemented rats compared with that in controls, suggesting that it is involved in preventing and controlling obesity-related diabetic complications. The novel findings of this study that GIP is expressed in the liver, is likely to be added to the story regarding GIP modification of the obese diabetic state.

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Vitamin B and its derivatives for diabetic kidney disease

Cited by 22 publications

References 107 publications

Untargeted Metabolomics Reveals the Protective Effect of a Traditional Chinese Herbal Decoction on Cisplatin‐Induced Acute Kidney Injury

Untargeted Metabolomics Reveals the Protective Effect of a Traditional Chinese Herbal Decoction on Cisplatin‐Induced Acute Kidney Injury

Vitamin B12 Deficiency and the Role of Gender: A Cross-Sectional Study of a Large Cohort

Hepatic glucose-dependent insulinotropic polypeptide expression is modified by supplementing high-dose thiamine in obese diabetic rats

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