Vitamin and Mineral Deficiencies Are Highly Prevalent in Newly Diagnosed Celiac Disease Patients

Wierdsma, N.J.; Schueren, Marian A.E. de van der; Berkenpas, Marijke; Mulder, Chris J.; Bodegraven, Ad A. van

doi:10.3390/nu5103975

Cited by 221 publications

(239 citation statements)

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“…Vitamin and mineral deficiencies may also be seen depending on malabsorption. The limited number of studies performed regarding the frequency of vitamin and mineral deficiencies in adult patients with celiac disease reported the frequency of vitamin and mineral deficiencies in varying rates up until now (11,14,17). A recent study Our particular study has revealed the presence of zinc deficiency in two-thirds of the patients with celiac disease at the time of diagnosis and vitamin D deficiency in more than half.…”

Section: Discussionmentioning

confidence: 99%

“…We determined that 7.7% and 13.5% of patients with celiac disease presented with vitamin A deficiency and vitamin E deficiency, respectively, at the time of application. Similarly, Wierdsma et al (11) reported vitamin A deficiency in 7.5% of adult patients newly diagnosed with celiac disease. Hozyasz et al (25) investigated red blood cell tocopherol levels in 18 patients diagnosed with untreated celiac disease and reported lower than normal levels of tocopherol in all of the patients.…”

Section: Discussionmentioning

confidence: 99%

“…Our study has revealed zinc deficiency in twothirds of the patients at the time of diagnosis. Likewise, Wierdsma et al (11) previously reported zinc deficiency in 67% of adult patients with celiac disease.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin and mineral deficiency in children newly diagnosed with celiac disease

Topal¹,

Çatal²,

Acar³

et al. 2015

Turk J Med Sci

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IntroductionCeliac disease is a chronic autoimmune disease that particularly affects the proximal small bowel (1). An autoimmune-mediated mechanism plays a part in the pathophysiology of the disease, and small bowel mucosal injury and malabsorption occur due to the hypersensitivity to gluten in prone individuals. Vitamin and mineral deficiency may also be seen depending upon malabsorption. Consequently, the clinical symptoms of the disease are not limited to the gastrointestinal system and may appear with a heterogeneous clinical spectrum involving the extraintestinal system. The typical symptoms of the disease include chronic diarrhea, abdominal distention, and growth retardation (2,3). However, the disease may also manifest itself with extraintestinal findings related to the hematologic, endocrine, and autoimmune systems. Anemia is the most frequently seen disorder in the hematologic system that often develops due to iron deficiency (4-9). Hypocalcemia and osteopenia may also occur due to vitamin D deficiency (10,11). No extensive study has been conducted regarding the vitamin and mineral deficiencies of pediatric patients diagnosed with celiac disease up to the present. Accordingly, it is the objective of this study to determine the frequency of vitamin A, D, and E deficiency, as well as zinc and mineral deficiencies, in pediatric patients diagnosed with celiac disease at the time of application to our clinic. Materials and methodsThe files of the patients diagnosed with celiac disease and followed in our Pediatric Gastroenterology, Hepatology, and Nutrition Clinic from June 2008 to June 2013 were reviewed retrospectively. Patients with complete file records and vitamin and mineral levels checked at the time of application were enrolled in the study. The demographic characteristics, complaints at the time of application, findings of duodenal biopsy, and serum 25 OH vitamin D, vitamin A, vitamin E, iron, and zinc levels of the patients were taken from the file records. The study was approved by the Ethics Committee of İnönü University (approval number 162/2013).The diagnosis of celiac disease was established in accordance with the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition's guidelines Background/aim: To establish the frequency of vitamin and mineral deficiency in children newly diagnosed with celiac disease. Materials and methods:The files of patients diagnosed with celiac disease in our Pediatric Gastroenterology Clinic from June 2008 to June 2013 were reviewed retrospectively.Results: A total of 52 pediatric patients diagnosed with celiac disease via serology and duodenal biopsy and who fulfilled the study criteria were enrolled in the study. The mean diagnosis age of the patients was 8.5 ± 3.9 years and 33 (63.5%) of the patients were female. Vitamin D, vitamin A, vitamin E, zinc, and iron deficiencies were determined in 27 (51.9%), 4 (7.7%), 7 (13.5%), 35 (67.3%), and 18 (34.6%) patients, respectively, at the time of diagnosis. Vitamin D deficiency was observed more frequent...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin and mineral deficiency in children newly diagnosed with celiac disease

Topal¹,

Çatal²,

Acar³

et al. 2015

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…8,43,44 Hay mínima información en pacientes pediátricos, por lo que no conocemos si esta deficiencia se debe a condiciones de los adultos o bien requiere un tiempo prolongado para que aparezcan las manifestaciones bioquímicas y clínicas.…”

Section: Deficiencia De Folatounclassified