Vitamin A, zinc and lung cancer

Atukorala, Sunethra; Basu, Tapan K.; Dickerson, J. W. T.; Donaldson, David; Sakula, Alex

doi:10.1038/bjc.1979.287

Cited by 84 publications

(23 citation statements)

References 23 publications

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“…Our findings agree with those of previous retrospective studies (13)(14)(15), and except for one study (16). further support for our data is provided by prospective epidemiological studies (8,(17)(18)(19) retrospective studies (20).…”

Section: Discussionsupporting

confidence: 93%

Serum carotenoids and uric acid levels in relation to cancer

Burgaz

Torun

Yardım

et al. 1996

Journal of Clinical Pharmacy and Therapeutics

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SUMMARY .We studied the levels of serum total carotenoids and uric acid in newly diagnosed cancer cases. The levels of carotenoids and uric acid in serum samples from 94 subjects with cancer affecting different sites (21 breast, 26 head and neck, 13 lung, 17 genitourinary and 17 other sites) were compared with those of 92 controls who were matched for age, sex, Quetelet index and smoking history. Mean ( f SE) levels of carotenoids were significantly lower among the cases than the controls (51.41 f 3-32 vs. 102.75 f 4.52 pgldl, P

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Section: Discussionsupporting

confidence: 93%

Serum carotenoids and uric acid levels in relation to cancer

Burgaz

Torun

Yardım

et al. 1996

Journal of Clinical Pharmacy and Therapeutics

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“…Low plasma levels of vitamin A have also been found in patients with lung cancer and this has been confirmed in a larger series of patients (Atukorala et al 1979). In this latter at https://www.cambridge.org/core/terms.…”

supporting

confidence: 58%

Nutrition and the Patient with Cancer

Dickerson

1981

Proc. Nutr. Soc.

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Previous papers in this symposium have been concerned largely with nutrition as a factor in the aetiology of cancer. It is right that we should be concerned with these aspects of the problem for a large proportion of oncological disease is environmentally induced and therefore at least potentially preventable. This is the more urgent for our attention because the results of treatment are far from good, at least for the more common kinds. Treatment of breast cancer, for instance, is scarcely more successful now in terms of five year, and certainly in terms of ten year, survival than it was forty years ago. It is equally urgent that we consider the nutrition of the patient with cancer, for the successful treatment of the disease is of little consequence if the patient dies of malnutrition in the process. Moreover, it may be that nutrition, and possibly individual nutrients, may be exploited to increase the effectiveness of treatment and that nutrition can therefore play an adjuvant role in the treatment of the disease. Effects of cancer on nutritionMany patients with cancer show evidence of weight loss and reduction of body fat and muscle mass (Soukop & Calman, 1979). Many patients also have low concentrations of plasma albumin and biochemical indicators of vitamin status provide evidence of vitamin depletion. If this condition of malnutrition continues the syndrome known as 'cancer cachexia' develops. This condition is complex and is characterized by anorexia and early satiety, an increase in the basal metabolic rate (BMR) and energy expenditure, the development of anaemia, asthenia and changes in body composition. T h e increases in BMR, oxidative metabolism and plasma amino acid concentrations that occur in cachexia distinguish the condition from simple starvation and indicate that in cachexia there is a failure of adaptation to a reduced food intake. Cachexia is probably multifactorial in its aetiology and the biochemical changes leading to its development uncertain. There is evidence to suggest that tumours may produce peptides or other small molecules which when taken up by normal cells cause disturbances of the enzymes in those cells resulting in a condition of 'metabolic chaos', increase in energy expenditure and a release into the blood stream of amino acids and peptides which enter the metabolic pool and are taken up by the tumour for the growth of its own tissue (Theologides, Malnutrition in the cancer patient results from a poor food intake and this may be caused by a reduction in appetite, changes in taste perception, pain, mechanical obstruction and apathy and depression in the face of an uncertain or poor 1977).

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“…However, in a case-control study, the plasma concentrations of RBP were found to be normal in samples taken 2-7 years before the development of clinically manifested lung tumours (Haines et al, 1982). While there have been a number of studies showing low concentrations of both plasma retinol and RBP in patients with an established tumour (Atukorala et al, 1979;Basu et al, 1982).…”

Section: Discussionmentioning

confidence: 93%

“…Subnormal levels of plasma retinol have been reported in cancers of the bronchus (Basu et al, 1976); lung (Atukorala et al, 1979); oropharynx (Ibrahim et al, 1977) and GI tract (Abels et al, 1941). In these studies, blood samples were taken from patients who still had a tumour.…”

Section: Discussionmentioning

confidence: 99%

“…These are epidemiological studies of dietary intake and cancer incidence (Bjelke, 1975;Hirayama, 1979;Mettlin & Graham, 1979;Graham et al, 1981); biochemical studies involving comparison of plasma retinol levels in cancer cases and controls (Basu et al, 1976Ibrahim et al, 1977;Atukorala et al, 1979; and biochemical studies of retinol status in those who are destined to develop cancer (Wald et al, 1980;Kark et al, 1981). These studies have consistently implied that low plasma or dietary intake of retinol may be associated with increased risk of developing cancer.…”

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confidence: 99%

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Retinol and postoperative colorectal cancer patients

Basu¹,

Chan²,

Fields³

et al. 1985

Br J Cancer

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Summary In order to determine whether low plasma levels of retinol and its carrier (retinol binding protein) are related to increased risk of cancer recurrence, these were measured in 103 patients who had had colorectal cancer surgically removed. According to the modification of the Dukes' classification, 66 had B2 tumours (with no nodal involvement' and 37 had C tumours (with lymph-node metastases). These patients were part of the Cross Cancer Institute Adjuvant GI Cohorts who were on the control arms receiving no further treatment. At the time of blood sample collection, they were believed to be free of neoplastic disease. The post-operative patients were found to be associated with subnormal circulatory levels of retinol (43.3 pg dl-1 vs 65.3 pg dl-1) and its carrier protein (4.6mg dl-1 vs 5.7 mgdl-1), when compared with apparently healthy subjects. The latter being more markedly depressed in patients with "C" type tumour (3.8 mgdl-1) than that in those with "B2" type tumour (5.0mg dl-1). These findings appeared to be persistent during the follow-up study when a second blood sample was collected, one to four months later from 40 patients. Furthermore, the initial plasma retinol level in conjunction with RBP was found to be even lower in 12 patients (35.1 pg dl-1, 3.7 mg dl -1) who subsequently had cancer recurrence than in those who remained free of apparent cancer (44.5 g dl -1, 4.6 mg dl -1). The lowest initial values of retinol (19.3 pg; 18.8 pg dl-1) and RBP (2.4; 1.6 mg dl -1) recorded in the study were seen in the only two patients who died of the disease at the time of follow-up.

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Vitamin A, zinc and lung cancer

Cited by 84 publications

References 23 publications

Serum carotenoids and uric acid levels in relation to cancer

Serum carotenoids and uric acid levels in relation to cancer

Nutrition and the Patient with Cancer

Retinol and postoperative colorectal cancer patients

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