Vitamin A, Vitamin D, Cartilage, Bones, and Teeth

McLean, Franklin C.; Budy, Ann M.

doi:10.1016/s0083-6729(08)60238-1

Cited by 7 publications

(6 citation statements)

References 41 publications

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“…In 1919, a British doctor, Edward Mellanby, noticed that dogs fed cod liver oil did not develop rickets and concluded that cod liver oil could prevent the disease 6. In 1921, Elmer McCollum tested modified cod liver oil in which the vitamin A had been destroyed, which also cured sick dogs, so McCollum concluded that the factor in cod liver oil which cured rickets was distinct from vitamin A 7–9. It was called “vitamin D” because it was the fourth vitamin to be named, following an alphabetical code.…”

Section: Introductionmentioning

confidence: 99%

“… 6 In 1921, Elmer McCollum tested modified cod liver oil in which the vitamin A had been destroyed, which also cured sick dogs, so McCollum concluded that the factor in cod liver oil which cured rickets was distinct from vitamin A. 7 – 9 It was called “vitamin D” because it was the fourth vitamin to be named, following an alphabetical code. The molecular geometry of vitamin D 2 was determined in 1932 10 and that of vitamin D 3 in 1936 as a result of ultraviolet irradiation of 7-dehydrocholesterol.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D status and peripheral arterial disease: evidence so far

Chua¹,

Chan²,

Cheng³

2011

VHRM

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BackgroundVitamin D deficiency has recently been implicated as a contributory factor in the development of peripheral arterial disease (PAD).MethodsA review of the published literature on PAD and vitamin D was undertaken using Medline, PubMed, and Embase, and cross-referenced. All relevant published papers on the subject were reviewed.ResultsPublished studies have shown that there is a significant association between vitamin D and PAD. Populations with lower vitamin D levels are more likely to develop PAD in a graded manner. Higher amputation rates are also observed among patients with PAD and lower vitamin D levels. In addition, vitamin D deficiency is significantly associated with increased risk of cardiovascular adverse events. This was also observed in the mouse model where low vitamin D led to the development of atherosclerosis.ConclusionThis study shows that vitamin D deficiency could be an independent risk factor for the development of PAD and that this risk factor is easily correctable. Further studies should look into the effects of vitamin D supplementation in patients with PAD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D status and peripheral arterial disease: evidence so far

Chua¹,

Chan²,

Cheng³

2011

VHRM

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“…Our calculations show that one cannot get reliable energy results for the ionized states by using the exponents of the AO'S of the ground state for their computations. However, the total energies and molecular constants of the higher ionized states calculated with the optimized exponents of the ground ionized state N$(X % : ) show a fair agreement (see Tables XI, XIa So far in most cases, the molecular constants appropriate to the theoretical potential energy curves have been obtained by Dunham's analysis [18][19][20], which essentially implies the use of the portion of the P.E. curve in the region of potential minimum only.…”

Section: Discussionmentioning

confidence: 96%

Quantum‐mechanical treatment of molecules. I. Calculations of the potential energy curves and molecular constants of the ground and ionized states of N₂

Sahni

Sawhney

1967

Int J of Quantum Chemistry

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AbstractsThe self-consistent-field molecular-orbital method in LCAO (linear combination of atomic orbitals) approximation is applied to the ground and three ionized states of N, at a number of internuclear distances for the computation of the potential energy curves. In these calculations both the linear coefficients and the screening constants of the atomic orbitals have been optimized. The molecular constants w e , wexe , Be , u, , and Re have also been calculated for the above states from the computed potential energy curves. The computed spectral results are compared with the experimental data as well as with the results reported by others from ab initio calculations.On a calcult l'ttat fondamental et trois ttats ionists de N, pour plusieurs distances inttrnucltaires selon l'approximation SCF-MO-LCAO. Les

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“…The biological functions of vitamin D are divided into classical (32,39,40) and non-classical (1,6,24), as displayed in Figure 1.…”

Section: Vitamin D Functionmentioning

confidence: 99%

Insights Into the Role of Vitamin D as a Biomarker in Stem Cell Transplantation

et al. 2020

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Vitamin D was discovered 100 years ago and since then multiple studies have consistently proved its effect on bone health and mineral metabolism. Further research has also explored its so-called "non-classical" biological effects, encompassing immune regulation and control of cell proliferation and differentiation. Vitamin D downregulates pro-inflammatory immune cells and subsequently their cytokine production, while enhancing the anti-inflammatory subsets, thus mediating inflammation and fostering a more tolerogenic environment. Its biological action is exerted through the vitamin D receptor, a nuclear receptor that mediates gene transcription and is expressed in most cells from the innate and adaptive immunity. Owing to its immune-modulatory properties, its role in cancer pathophysiology, hematology disorders and stem cell transplantation has also been investigated. Vitamin D deficiency causes immune imbalance and cytokine dysregulation, contributing to some autoimmune diseases. In the hematopoietic stem cell transplant setting this could lead to complications such as acute and chronic graft-versus-host disease, ultimately impacting transplant outcomes. Other factors have also been linked to this, including specific polymorphisms of the vitamin D receptor in both stem cell donors and recipients. Nevertheless, studies thus far have shown conflicting results and the use of vitamin D or its receptor as biomarkers has not been validated yet, therefore there are no evidence-based consensus guidelines to guide clinicians in their day-today practice. To gain more insight in this topic, we have reviewed the existent literature and gathered the current evidence. This is an overview of the role of serum vitamin D and its receptor as biomarkers for clinical outcomes in patients undergoing hematopoietic stem cell transplantation. Further prospective studies with larger cohorts are warranted to validate the viability of using serum vitamin D, and its receptor, as biomarkers in potential stem cell donors and patients, to identify those at risk of post-transplant complications and enable early therapeutic interventions.

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Vitamin A, Vitamin D, Cartilage, Bones, and Teeth

Cited by 7 publications

References 41 publications

Vitamin D status and peripheral arterial disease: evidence so far

Vitamin D status and peripheral arterial disease: evidence so far

Quantum‐mechanical treatment of molecules. I. Calculations of the potential energy curves and molecular constants of the ground and ionized states of N₂

Insights Into the Role of Vitamin D as a Biomarker in Stem Cell Transplantation

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Vitamin A, Vitamin D, Cartilage, Bones, and Teeth

Cited by 7 publications

References 41 publications

Vitamin D status and peripheral arterial disease: evidence so far

Vitamin D status and peripheral arterial disease: evidence so far

Quantum‐mechanical treatment of molecules. I. Calculations of the potential energy curves and molecular constants of the ground and ionized states of N2

Insights Into the Role of Vitamin D as a Biomarker in Stem Cell Transplantation

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Quantum‐mechanical treatment of molecules. I. Calculations of the potential energy curves and molecular constants of the ground and ionized states of N₂