Vitamin A supplementation is effective for improving the clinical symptoms of urinary tract infections and reducing renal scarring in girls with acute pyelonephritis: a randomized, double-blind placebo-controlled, clinical trial study

Kahbazi, Manijeh; Sharafkhah, Mojtaba; Yousefichaijan, Parsa; Taherahmadi, Hassan; Rafiei, Mohammad; Kaviani, Parisa; Abaszadeh, Sahand; Massoudifar, Ali; Mohammadbeigi, Abolfazl

doi:10.1016/j.ctim.2018.12.007

Cited by 19 publications

(10 citation statements)

References 25 publications

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“…A meta-analysis could however not demonstrate a beneficial effect, except as an adjuvant to antibiotic prophylaxis [46]. Even though more studies into supplements are warranted, Vitamin A showed promising results in preventing renal scarring in children with acute pyelonephritis [47,48] and Vitamin E could possibly ameliorate the symptoms of UTI [49].…”

Section: Preventative Measuresmentioning

confidence: 99%

Update of the EAU/ESPU guidelines on urinary tract infections in children

Hoen

Bogaert

Radmayr

et al. 2021

Journal of Pediatric Urology

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Section: Preventative Measuresmentioning

confidence: 99%

Update of the EAU/ESPU guidelines on urinary tract infections in children

Hoen

Bogaert

Radmayr

et al. 2021

Journal of Pediatric Urology

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“…Apart from antibiotic treatment, vitamin A supplementation was proven to be efficient in decreasing renal scarring secondary to acute pyelonephritis and in relieving symptoms such as fever, urinary frequency and poor feeding duration in girls with acute pyelonephritis . Probiotic prophylaxis of Lactobacillus species was as effective in infants with pyelonephritis and normal urinary tract as antibiotic prophylaxis with trimethoprim/sulfamethoxazole .…”

Section: Discussionmentioning

confidence: 99%

Risk factors affecting the prognosis of urinary tract infection in Chinese pediatric patients: Single‐center experience

Wang

Zhu

Huang

et al. 2020

Pediatrics International

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Background Urinary tract infection (UTI) is common in children. The purpose of this retrospective study was to determine the various risk factors that usually affect the prognosis of UTI in children diagnosed with the disease. Methods In the present retrospective study, we enrolled all pediatric patients diagnosed with UTI and hospitalized between 1 January 2013 and 31 July 2016 at Nanjing Children's Hospital. We then collected all the relevant patient clinical demographics and characteristics. Results The study involved 2,092 pediatric patients diagnosed with UTI. On logistic regression analysis, factors that could affect the prognosis of pediatric UTI were complications, hospitalization, intensive care unit (ICU) admission, type of UTI, urine culture results, blood lymphocytes, urine nitrites (NIT) and antibiotics (unstandardized coefficients, 0.06, <0.001, −0.28, 0.32, <0.001, 0.01, −0.11, 0.01, respectively, all P < 0.001). Conclusion Complications, hospitalization, type of UTI, urine culture results, blood lymphocytes, and antibiotics had a significant, positive association with UTI prognosis. Meanwhile, ICU admission and urine NIT had a negative association with prognosis.

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“…Generally speaking, girls due to their shorter urethras are more susceptible to get AP compared to boys. However, boy populations with UTIs typically possess underlying anatomical or functional abnormalities of the genitourinary tract with a higher primary scarring rate [24]. The most common pathogen causing AP in children patients was E. coli.…”

Section: Discussionmentioning

confidence: 99%

Clinical Manifestations, Laboratory Markers, and Renal Ultrasonographic Examinationsin 1-month to12-year-old Iranian Children with Pyelonephritis: A Six-year Cross-sectional Retrospectivestudy

Fahimi

Khedmat

Afshin

et al. 2020

Preprint

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Background: Upper urinary tract infection (UTI) or pyelonephritismay increase the pathogenesis rate and risk of severe complications in children due to the atrophy of the kidneys.Objective: A set of clinical symptoms, laboratory markers, and ultrasound findings were assessed to reach early diagnosis and prognosis of pyelonephritis in hospitalized pediatrics.Methods: A cross-sectional study was conducted on 104 Iranian children (95 girls and 9 boys) aged 1 month to 12 years with acute pyelonephritis during 2012-2018. The ultrasound examination of kidneys and urinary tract during the hospitalization period, the incidence of clinical symptoms, and the monitoring of laboratory markersin blood and urine were studied to identify the best predictive factors of early diagnosis of this bacterial infection.Results: Three-fourth of the patients had one of the four clinical symptoms of abdominal pain, constipation, dysuria, andvomiting, whileotherswere asymptomatic. A considerable frequency of pyuria(88.4%), Escherichia coli in urine (92%), leukocytosis (81.7%), and high ESR (> mm/h, 80%) and CRP (> 10mg/L, 82.8%) was observed. The kidney and urinary tract ultrasonography onlyin 32.7% of children showed in favor of pyelonephritis (cystitis, ureteral stones, and hydronephrosis).Conclusion: In the majority of patients, there was a high prevalence of clinical signs and laboratory markers associated with pyelonephritis. Since most patients have normal sonography, ultrasound alonecould notbe an efficient tool fortracingfebrile UTI.

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Vitamin A supplementation is effective for improving the clinical symptoms of urinary tract infections and reducing renal scarring in girls with acute pyelonephritis: a randomized, double-blind placebo-controlled, clinical trial study

Cited by 19 publications

References 25 publications

Update of the EAU/ESPU guidelines on urinary tract infections in children

Update of the EAU/ESPU guidelines on urinary tract infections in children

Risk factors affecting the prognosis of urinary tract infection in Chinese pediatric patients: Single‐center experience

Clinical Manifestations, Laboratory Markers, and Renal Ultrasonographic Examinationsin 1-month to12-year-old Iranian Children with Pyelonephritis: A Six-year Cross-sectional Retrospectivestudy

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