Vitamin A supplementation during pregnancy for maternal and newborn outcomes

McCauley, Mary; Broek, Nynke van den; Dou, Lixia; Othman, Mohammad

doi:10.1002/14651858.cd008666.pub2

Cited by 90 publications

(26 citation statements)

References 138 publications

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“…However, as summarized in a recent systematic review by van den Broek et al (26), maternal vitamin A supplementation can reduce the risks of clinical maternal infection, night blindness, and anemia. In Nepal, where maternal mortality risk and vitamin A deficiency were major problems, dietary supplementation of mothers with vitamin A reduced all-cause mortality related to pregnancy (27).…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin A and β-carotene supplementation on birth size and length of gestation in rural Bangladesh: a cluster-randomized trial

Christian¹,

Klemm²,

Shamim³

et al. 2013

The American Journal of Clinical Nutrition

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In this rural South Asian population with a high burden of LBW and preterm birth but modest levels of maternal vitamin A deficiency, antenatal vitamin A or β-carotene supplementation did not benefit these birth outcomes. Other nutritional and nonnutritional interventions should be examined to reduce risks of these adverse outcomes in rural South Asia. This trial was registered at clinicaltrials.gov as NCT00198822.

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Section: Discussionmentioning

confidence: 99%

Effects of vitamin A and β-carotene supplementation on birth size and length of gestation in rural Bangladesh: a cluster-randomized trial

Christian¹,

Klemm²,

Shamim³

et al. 2013

The American Journal of Clinical Nutrition

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“…In babies born prematurely, symptoms of vitamin A deficiency include broncho-pulmonary dysplasia (a form of chronic lung disease). Night blindness is thought to be one of the first signs of vitamin A deficiency, followed by a diminished ability to fight infections especially respiratory and gastro enteric infections 70 . Vitamin A deficiency in pregnancy is known to result in night blindness, to increase the risk of maternal mortality and is associated with premature birth, intrauterine growth retardation, LBW and abruptio placentae.…”

Section: Vitamin Amentioning

confidence: 99%

“…Increased maternal levels of preformed vitamin A (retinoic acid) have been shown to be associated with miscarriage and with malformations involving the central nervous and cardiac systems. A World Health Organization (WHO) expert group consultation concluded that daily doses of up to 10,000 IU (equivalent to 3000 mcg retinol) or 25,000 IU weekly after day 60 are probably safe, especially in areas where vitamin A deficiency is thought to be common 70 .…”

Section: Vitamin a Supplementationmentioning

confidence: 99%

Prevalence of Anemia Among Pregnant Women in Ethiopia and Its Management: A Review

Tsegaye¹,

Tesfaye²

2014

Int. Res. J. Pharm.

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Anemia is a major global health problem, especially in developing countries and is a common and serious problem in pregnancy. It has serious short-and long-term consequences during pregnancy and beyond. This fundamental health issue has not still been solved but continues to exist affecting the health, quality of life and working capacity in billions of people all over the world. The anemic condition is often worsened by the presence of other chronic diseases such as malaria, tuberculosis, HIV, and diabetes. Untreated anemia also leads to increased morbidity and mortality from these chronic conditions as well. Current knowledge indicates that iron deficiency anemia in pregnancy is a risk factor for preterm delivery and subsequent low birth weight, and possibly for inferior neonatal health. Even for women who enter pregnancy with reasonable iron stores, iron supplements improve iron status during pregnancy and for a considerable length of time postpartum, thus providing some protection against iron deficiency in the subsequent pregnancy. This literature review focuses on the prevalence and major causes of anemia seen on a global & Ethiopian scale. Most cases of anemia are due to iron deficiency, which often work in combination with folate deficiency and/or vitamin B12 deficiency as well as with infections. More efforts should be dedicated to tackle this massive problem-we have the tools and we know the ways. Iron fortification of appropriate food items combined with iron supplements in specific population groups has proved to be efficient. Initially, the efforts should be centered on the specific risk groups for iron deficiency anemia, i.e. pregnant women.

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“…As a consequence, the Cochrane Editorial Unit and 5 CRGs were commissioned to complete or update 12 reviews relating to vitamin A in advance of the guidelines process relating to the vitamin based on questions in the PICO format identified by a panel of experts identified by the WHO micronutrients group (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Since the work on vitamin A was completed, the Cochrane Editorial Unit has also contributed to work on other guidelines programs, including those on iron.…”

Section: What Is the Cochrane Collaboration?mentioning

confidence: 99%

The Role of The Cochrane Collaboration in Support of the WHO Nutrition Guidelines

Tovey

2014

Advances in Nutrition

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This article describes the background and contribution of The Cochrane Collaboration to the WHO Nutrition Guidelines program. Systematic reviews, augmented by the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology for assessing the quality of a body of evidence, form the evidence basis for WHO guidelines. Our shared experience of working together has highlighted a number of issues that are challenging, such as decisions made about selecting appropriate questions for evidence synthesis and the nature of study types that are included, in particular the decision on whether or not to extend a search beyond randomized studies. Although the skills and experience required for evidence synthesis are different from those needed to determine recommendations for policy and practice, our experience suggests that some engagement between the two groups is mutually beneficial. Finally, our experience highlights the recognition that evidence of effectiveness is essential but by no means sufficient to guide decisions on recommendations. Programmatic and implementation considerations are important to guide decision making and the evidence basis for this may be limited; therefore, it is essential that groups involved in delivering interventions to populations are also engaged in the guidelines process.

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Vitamin A supplementation during pregnancy for maternal and newborn outcomes

Cited by 90 publications

References 138 publications

Effects of vitamin A and β-carotene supplementation on birth size and length of gestation in rural Bangladesh: a cluster-randomized trial

Effects of vitamin A and β-carotene supplementation on birth size and length of gestation in rural Bangladesh: a cluster-randomized trial

Prevalence of Anemia Among Pregnant Women in Ethiopia and Its Management: A Review

The Role of The Cochrane Collaboration in Support of the WHO Nutrition Guidelines

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