Vitamin A supplementation during pregnancy for maternal and newborn outcomes

Broek, Nynke van den; Dou, Lixia; Othman, Mohammad; Neilson, James P; Gülmezoglu, A Metin

doi:10.1002/14651858.cd008666

Cited by 13 publications

(16 citation statements)

References 39 publications

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“…The approach would not seem to be founded as maternal VAS was not associated with reduced risk of mortality or mortality in babies during infancy or in the neonatal period [22 && ]. Only one RCT conducted in Nepal showed a positive effect of VAS in pregnant women for maternal and newborn outcomes [24,25]. However, all subsequent RCT highlighted the lack of benefit of maternal VAS on miscarriage, maternal or infant mortality and morbidity [24,26 && , 27-29,30 && ].…”

Section: Vitamin a Supplementation In Pregnant Women Or Postpartum Momentioning

confidence: 99%

Vitamin A supply to mothers and children

Sauvant

Féart²,

Atgié³

2012

Current Opinion in Clinical Nutrition and Metabolic Care

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Despite massive vitamin A supplementation public health policies in developing countries, the burden of VAD is still common and efforts should be maintained to better target populations at risk, and to develop alternative strategies for supplementation based on sustainable and integrated approaches. In industrialized countries, VAD due to insufficient intake is scarce, but it may surprisingly occur due to the decreased absorption of lipids following antiobesity treatments. Specific approaches should be developed to better monitor and supplement obese childbearing women who have undergone bariatric surgery.

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Section: Vitamin a Supplementation In Pregnant Women Or Postpartum Momentioning

confidence: 99%

Vitamin A supply to mothers and children

Sauvant

Féart²,

Atgié³

2012

Current Opinion in Clinical Nutrition and Metabolic Care

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“…Pregnancy outcomes that have been associated with VAD in Nigeria and other developing countries include stillbirth, pre‐eclampsia, maternal night‐blindness, maternal IDA and mother‐to‐child transmission of HIV (Radhika et al. , 2002; van den Broek et al. , 2010; Williams et al.…”

Section: Introductionmentioning

confidence: 99%

Maternal nutrition among women from Sub‐Saharan Africa, with a focus on Nigeria, and potential implications for pregnancy outcomes among immigrant populations in developed countries

Lindsay

Gibney

McAuliffe

2012

J Human Nutrition Diet

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Lindsay K.L., Gibney E.R. & McAuliffe F.M. (2012) Maternal nutrition among women from Sub‐Saharan Africa, with a focus on Nigeria, and potential implications for pregnancy outcomes among immigrant populations in developed countries. J Hum Nutr Diet. Abstract Pregnant women in countries of Sub‐Saharan Africa (SSA) are at risk of poor nutritional status and adverse outcomes as a result of poverty, food insecurity, sub‐optimal healthcare facilities, frequent infections and frequent pregnancies. Studies from Nigeria, for example, have revealed a high prevalence of both under‐ and over‐nutrition, as well as nutrient deficiencies, including iron, folate, vitamin D and vitamin A. Subsequently, obstetric complications, including hypertension, anaemia, neural tube defects, night‐blindness, low birth weight and maternal and perinatal mortality, are common. Migration patterns from SSA to the Western world are on the rise in recent years, with Nigerians now representing the most prevalent immigrant African population in many developed countries. However, the effect of immigration, if any, on the nutritional status and pregnancy outcomes of these women in their host countries has not yet been studied. Consequently, it is unknown to what extent the nutritional deficiencies and pregnancy complications occurring in Nigeria, and other countries of SSA, present in these women post‐emigration. This may result in missed opportunities for appropriate antenatal care of a potential high‐risk group in pregnancy. The present review discusses the literature regarding nutrition in pregnancy among SSA women, using Nigeria as an example, the common nutrition‐related complications that arise and the subsequent obstetric outcomes. The concept of dietary acculturation among immigrant groups is also discussed and deficiencies in the literature regarding studies on the diets of pregnant immigrant women are highlighted.

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“…Extreme vitamin A deficiency is lethal for the embryo, while minor deficiencies, below half the RDA, mainly induce ocular abnormalities. 95,96 Doses slightly above the RDA (1,500 mg) were found to protect against CLP 97 and CP 19 in the offspring. On the other hand, other studies did not find such an effect.…”

Section: High Versus Low Doses Of Vitamin Amentioning

confidence: 89%

Vitamin A and clefting: putative biological mechanisms

et al. 2011

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Nutritional factors such as vitamin intake contribute to the etiology of cleft palate. Vitamin A is a regulator of embryonic development. Excess vitamin A can cause congenital malformations such as spina bifida and cleft palate. Therefore, preventive nutritional strategies are required. This review identifies putative biological mechanisms underlying the association between maternal vitamin A intake and cleft palate. Excessive vitamin A may disturb all three stages of palatogenesis: 1) during shelf outgrowth, it may decrease cell proliferation and thus prevent tissue development; 2) it may prevent shelf elevation by affecting extracellular matrix composition and hydration; and 3) during shelf fusion, it may affect epithelial differentiation and apoptosis, which precludes the formation of a continuous palate. In general, high doses of vitamin A affect palatogenesis through interference with cell proliferation and growth factors such as transforming growth factor β and platelet-derived growth factor. The effects of lower doses of vitamin A need to be investigated in greater depth in order to improve public health recommendations.

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Vitamin A supplementation during pregnancy for maternal and newborn outcomes

Cited by 13 publications

References 39 publications

Vitamin A supply to mothers and children

Vitamin A supply to mothers and children

Maternal nutrition among women from Sub‐Saharan Africa, with a focus on Nigeria, and potential implications for pregnancy outcomes among immigrant populations in developed countries

Vitamin A and clefting: putative biological mechanisms

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