Vitamin A supplementation and neonatal mortality in the developing world: a meta-regression of cluster-randomized trials

Rotondi, Michael; Khobzi, Nooshin

doi:10.2471/blt.09.068080

Cited by 28 publications

(23 citation statements)

References 31 publications

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“…The heterogeneity of the population included in these trials might explain these controversial results [31,32]. Indeed, a linear relationship between the prevalence of VAD in pregnant women and the observed effectiveness of VAS at birth has been suggested [31]. VAS might reduce infant mortality only in regions where its deficiency is more common.…”

Section: Vitamin a Supplementation In Pregnant Women Or Postpartum Momentioning

confidence: 97%

“…However, all subsequent RCT highlighted the lack of benefit of maternal VAS on miscarriage, maternal or infant mortality and morbidity [24,26 && , 27-29,30 && ]. The heterogeneity of the population included in these trials might explain these controversial results [31,32]. Indeed, a linear relationship between the prevalence of VAD in pregnant women and the observed effectiveness of VAS at birth has been suggested [31].…”

Section: Vitamin a Supplementation In Pregnant Women Or Postpartum Momentioning

confidence: 98%

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Vitamin A supply to mothers and children

Sauvant

Féart²,

Atgié³

2012

Current Opinion in Clinical Nutrition and Metabolic Care

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Despite massive vitamin A supplementation public health policies in developing countries, the burden of VAD is still common and efforts should be maintained to better target populations at risk, and to develop alternative strategies for supplementation based on sustainable and integrated approaches. In industrialized countries, VAD due to insufficient intake is scarce, but it may surprisingly occur due to the decreased absorption of lipids following antiobesity treatments. Specific approaches should be developed to better monitor and supplement obese childbearing women who have undergone bariatric surgery.

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Section: Vitamin a Supplementation In Pregnant Women Or Postpartum Momentioning

confidence: 97%

Section: Vitamin a Supplementation In Pregnant Women Or Postpartum Momentioning

confidence: 98%

Vitamin A supply to mothers and children

Sauvant

Féart²,

Atgié³

2012

Current Opinion in Clinical Nutrition and Metabolic Care

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“…The World Health Organization (WHO) has recommended vitamin A supplementation of 100,000–200,000 IU every 4 to 6 months to increase its levels in VAD infants and children. Supplementation of large dose vitamin A (with or w/o vaccination) in randomized placebo controlled clinical trials in VAD regions suggests an overall positive effect on infection-related morbidity and mortality, varying however, with pathogen, age and gender (7–11). …”

Section: Introductionmentioning

confidence: 99%

Prenatally Acquired Vitamin A Deficiency Alters Innate Immune Responses to Human Rotavirus in a Gnotobiotic Pig Model

Vlasova

Chattha

Kandasamy

et al. 2013

The Journal of Immunology

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We examined how prenatally acquired vitamin A deficiency (VAD) modulates innate immune responses and human rotavirus (HRV) vaccine efficacy in a gnotobiotic (Gn) piglet model of HRV diarrhea. The VAD and vitamin A sufficient (VAS) Gn pigs were vaccinated with attenuated HRV (AttHRV) with or without concurrent oral vitamin A supplementation (100,000IU) and challenged with virulent HRV (VirHRV). Regardless of vaccination status, the numbers of conventional and plasmacytoid dendritic cells (cDCs and pDCs) were higher in VAD piglets pre-challenge, but decreased substantially post-challenge as compared to VAS pigs. We observed significantly higher frequency of CD103 (integrin αEβ7) expressing DCs in VAS vs. VAD piglets post-challenge, indicating that VAD may interfere with homing (including intestinal) phenotype acquisition. Post VirHRV challenge, we observed longer and more pronounced diarrhea and higher VirHRV fecal titers in non-vaccinated VAD piglets. Consistent with higher VirHRV shedding titers, higher IFNα levels were induced in control VAD vs. VAS piglet sera at post-challenge day (PCD)2. Ex vivo HRV-stimulated mononuclear cells (MNCs) isolated from spleen and blood of VAD pigs pre-challenge also produced more IFNα. In contrast at PCD10, we observed reduced IFNα levels in VAD pigs that coincided with decreased TLR3+ MNC frequencies. Numbers of necrotic MNCs were higher in VAD pigs in spleen (coincident with splenomegaly in other VAD animals) pre-challenge and intestinal tissues (coincident with higher VirHRV induced intestinal damage) post-challenge. Thus, prenatal VAD caused an imbalance in innate immune responses and exacerbated VirHRV infection, whereas vitamin A supplementation failed to compensate for these VAD effects.

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“…Rotondi and Khobzi (2010) reffered that the relation between the prevalence of vitamin A deficiency in pregnant and the effect of neonatal vitamin A supplementation on infant mortality [18]. Rondò et al (2001) referred that the Concentrations of vitamin A in cord blood correlated significantly with birth weight and length [19].…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin deficiency (A, C and D) in maternal on the weights of newborns

Abdulqader¹

2018

Tikrit J. Pure Sci.

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The present study was designed to find the relation between vitamin deficiency (A, C and D) of maternal and the weights of newborns. The study used 50 volunteers (40 pregnant women with vitamins deficiency and 10 pregnant women without vitamins deficiency). Pregnant women were divided to two groups according to vitamins state. Newborn weights directly were reported at birth time. Vitamins levels showeddecreased invitamin A, vitamin C and vitamin D in 40 pregnant female and normal in 10 pregnant female. Where, Vitamins levels showedsignificant decreased (P<0.05) 40 pregnant female 10 pregnant femalecompared with 10 normal pregnant female. Also, results show a high correlation between decreased vitamins levels and newborn weights. It was concluded from this study that the vitamins deficiency (A, C and D) in maternal led to decreased the weights of newborn.

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Vitamin A supplementation and neonatal mortality in the developing world: a meta-regression of cluster-randomized trials

Cited by 28 publications

References 31 publications

Vitamin A supply to mothers and children

Vitamin A supply to mothers and children

Prenatally Acquired Vitamin A Deficiency Alters Innate Immune Responses to Human Rotavirus in a Gnotobiotic Pig Model

Effects of vitamin deficiency (A, C and D) in maternal on the weights of newborns

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