Vitamin A status of children with a history of respiratory syncytial virus infection in infancy

Pinnock, Carole; Douglas, Robert M.; Martin, A. Lynn; Badcock, N R

doi:10.1111/j.1440-1754.1988.tb01364.x

Cited by 17 publications

(13 citation statements)

References 26 publications

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“…These data suggested that vitamin A might be a useful adjunctive therapy [94,109]. However, in a subsequent study oral administration of vitamin A did not decrease respiratory morbidity in children with acute RSV bronchiolitis [102].…”

Section: Other Therapiesmentioning

confidence: 95%

Treatment and prevention of respiratory syncytial virus infection

Mc¹,

Moll²,

R³

2000

Eur J Pediatr

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Section: Other Therapiesmentioning

confidence: 95%

Treatment and prevention of respiratory syncytial virus infection

Mc¹,

Moll²,

R³

2000

Eur J Pediatr

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“…In fact, some of the hospital-based studies suggest an apparent increase in indicators of severity associated with vitamin A supplementation (41,85,105,146). A number of community-based trials have also found an apparent increase in respiratory symptoms in relation to vitamin A supplementation (34,39,103,104,112,136,144), particularly among children who are not undernourished. It is not clear whether this apparent increase in respiratory symptoms may be due to a proinflammatory immune response associated with the supplements.…”

Section: Vitamin a Supplementation And Clinical Outcomesmentioning

confidence: 96%

Effects of Vitamin A Supplementation on Immune Responses and Correlation with Clinical Outcomes

2005

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Vitamin A supplementation to preschool children is known to decrease the risks of mortality and morbidity from some forms of diarrhea, measles, human immunodeficiency virus (HIV) infection, and malaria. These effects are likely to be the result of the actions of vitamin A on immunity. Some of the immunomodulatory mechanisms of vitamin A have been described in clinical trials and can be correlated with clinical outcomes of supplementation. The effects on morbidity from measles are related to enhanced antibody production and lymphocyte proliferation. Benefits for severe diarrhea could be attributable to the functions of vitamin A in sustaining the integrity of mucosal epithelia in the gut, whereas positive effects among HIV-infected children could also be related to increased T-cell lymphopoiesis. There is no conclusive evidence for a direct effect of vitamin A supplementation on cytokine production or lymphocyte activation. Under certain circumstances, vitamin A supplementation to infants has the potential to improve the antibody response to some vaccines, including tetanus and diphtheria toxoids and measles. There is limited research on the effects of vitamin A supplementation to adults and the elderly on their immune function; currently available data provide no consistent evidence for beneficial effects. Additional studies with these age groups are needed

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“…The various studies on the association between vitamin A deficiency and morbidity have not had very consistent results [17][18][19][20][21][22][23][24][25][26]. This may be explained by the fact that morbidity studies are hard to carry out.…”

Section: Vitamin a Deficiency And Morbiditymentioning

confidence: 97%

New Issues in Developing Effective Approaches for the Prevention and Control of Vitamin A Deficiency

Bloem¹,

Pee²,

Darnton‐Hill³

1998

Food Nutr Bull

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Even mild to moderate vitamin A deficiency is now recognized as an important factor in child health and survival. This has given increased emphasis to the goal of virtually eliminating vitamin A deficiency and its consequences, including blindness, by the end of the decade. The implications of vitamin A deficiency, however, vary according to the group at risk, and this needs to be addressed when looking at ways to achieve the goal. In preschool children, vitamin A deficiency can lead to increased risk of mortality and morbidity and to blindness. In pregnant and lactating women, it can lead to night-blindness and appears to have implications for maternal morbidity and mortality. Although the immediate health consequences for schoolchildren and adolescents are not completely known, they are probably less dramatic. Nevertheless, it is clear that there is a cross-generational cycle leading to and perpetuating vitamin A deficiency in affected communities. This also has implications when addressing prevention and control strategies. The existing, somewhat successful approach has been to target children aged six months to six years; it is implicit that this criterion is used to measure progress towards the end-ofdecade goals. A broader, complementary, life-cycle approach to vitamin A deficiency is now appropriate in many countries. There is increasing emphasis on such approaches, i.e., fortifying foods with vitamin A and improving the diet, which address the whole population at risk. A mix of interventions will give governments the chance to shift from a subsidized vitamin A capsule programme to more sustainable, non-subsidized, consumer-funded vitamin A interventions, although in an appreciable number of countries, supplementation with vitamin A will be a ne-

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Vitamin A status of children with a history of respiratory syncytial virus infection in infancy

Cited by 17 publications

References 26 publications

Treatment and prevention of respiratory syncytial virus infection

Treatment and prevention of respiratory syncytial virus infection

Effects of Vitamin A Supplementation on Immune Responses and Correlation with Clinical Outcomes

New Issues in Developing Effective Approaches for the Prevention and Control of Vitamin A Deficiency

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