Vitamin A retinopathy secondary to Billroth II anastomosis triggered after the beginning of dialysis

Sargues, Lidia Remolí; Hernández, Juan Antonio Rodríguez; Salvador, M. Ortiz; Peiro, B. Moratal; Adsuara, Clara Monferrer; Navarro, V. Castro; Palop, Catalina Navarro; Taulet, Enrique Cervera

doi:10.1177/11206721211027416

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…[56] Yine farklı vakalarda tedavi ile gerileyen periferik görme alanı defektleri bildirilmiştir. [41,57] Kseroftalmi tanısı klinik olarak konulur ve serum A vitamini seviyelerinin 35 µmol/dl'nin altında ölçülmesiyle doğrulanabilir. Erken tespit edilirse oral veya intramusküler A vitamini replasmanı ile oküler komplikasyonlar gelişmeden kalıcı görme kaybı engellenebilir.…”

Section: A Vitamini Eksikliği Ve çöLyak Hastalığıunclassified

Medications Damaging Retinal Pigment Epithelium and Photoreceptor Complex-3: Pathogenesis, Diagnosis and Treatment (Clofazimine, Deferoxamine, Vitamin A Deficiency and Celiac Disease, Digoxin)

2023

Güncel Retina (Current Retina)

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Toxic retinopathies are a variety of conditions resulting from retinal damage caused by systemically administered drugs. Although relatively rare, these conditions should be considered, especially when features of unusual retinopathy or maculopathy such as bilateral pigmentary disorder or retinal crystal deposition are present. It has been observed that some drugs damage the RPE and photoreceptor layer. Of these drugs, clofazimine; can be used in the treatment of tuberculosis, leprosy, and various cutaneous diseases, but it can cause color vision defects and bulls-eye maculopathy in a dose-dependent manner. Lesions detectable by various imaging methods have been described as associated with the use of deferoxamine mesylate, which is used as an iron-chelating agent. In vitamin A deficiency characterized by xerophthalmia symptoms, drusenoid deposits have been observed in the photoreceptor outer segment, in which rod function defects are prominent. In the use of digoxin, which has a very narrow therapeutic range, photoreceptor dysfunctions, which are manifested by deterioration in color perception, may develop. Most ocular side effects associated with systemic drug use are reversible after discontinuation of therapy if detected early. However, toxic effects can progress if undetected and cause retinal dysfunction associated with potentially irreversible vision loss.

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Section: A Vitamini Eksikliği Ve çöLyak Hastalığıunclassified

Medications Damaging Retinal Pigment Epithelium and Photoreceptor Complex-3: Pathogenesis, Diagnosis and Treatment (Clofazimine, Deferoxamine, Vitamin A Deficiency and Celiac Disease, Digoxin)

2023

Güncel Retina (Current Retina)

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Multimodal Imaging Study of Patients With Vitamin A Deficiency Retinopathy

Pichi¹,

Neri²,

Rishi³

et al. 2023

Ophthalmic Surg Lasers Imaging Retina

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Objectives: To describe multimodal imaging findings of vitamin A deficiency retinopathy. Methods: A retrospective study of patients with serum retinol < 0.3 mg/L. Fundus color photos, spectral domain-optical coherence tomography (SD-OCT), and fundus autofluorescence (FAF) were reviewed and, when available, electrophysiological tests were analyzed. Results: Forty-five eyes (63.9 ± 15.7 years) were included. Ultra-widefield fundus photography showed drusen-like deposits (53.3%) and macular retinal pigment epithelium (RPE) mottling (40%). The deposits were hypoautofluorescent, and a perifoveal hyperautofluorescent ring was present in 8.9%. By SD-OCT, the ellipsoid zone had an irregular appearance (100%) and conical deposits anterior to the RPE (33.3%). Electroretinogram (ERG) (66.7%) showed a decrease in b-wave in the scotopic registers, and microperimetry (4.4%) showed decreased foveal sensitivity. After vitamin A supplementation, SD-OCT and FAF showed resolution of all findings. Forty percent of eyes had restoration of the scotopic registers in ERG and improved macular sensitivity by microperimetry (4.4%). Conclusions: Vitamin A deficiency causes a mild cone dysfunction in addition to the more severe absent rod response. [ Ophthalmic Surg Lasers Imaging Retina 2023;54:330–336.]

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Vitamin A retinopathy secondary to Billroth II anastomosis triggered after the beginning of dialysis

Cited by 2 publications

References 10 publications

Medications Damaging Retinal Pigment Epithelium and Photoreceptor Complex-3: Pathogenesis, Diagnosis and Treatment (Clofazimine, Deferoxamine, Vitamin A Deficiency and Celiac Disease, Digoxin)

Medications Damaging Retinal Pigment Epithelium and Photoreceptor Complex-3: Pathogenesis, Diagnosis and Treatment (Clofazimine, Deferoxamine, Vitamin A Deficiency and Celiac Disease, Digoxin)

Multimodal Imaging Study of Patients With Vitamin A Deficiency Retinopathy

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