Vitamin A palmitate-bearing nanoliposomes: Preparation and characterization

Pezeshky, Akram; Ghanbarzadeh, Babak; Hamishehkar, Hamed; Moghadam, M.; Babazadeh, Afshin

doi:10.1016/j.fbio.2015.12.002

Cited by 72 publications

(35 citation statements)

References 37 publications

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“…3B, in the ratio of 66.6-16.6 (phospholipid-phytosterol) and at a time of sonication greater than 35 min' maximum stability obtained. Pezeshky et al (2016) demonstrated that, addition of cholesterol had no significant effect on the particle size of liposomes and however, its effect was more noticeable on stability of the particle size of nanoliposomes. As showed in Figs.…”

Section: Liposome Stabilitymentioning

confidence: 96%

New formulation of vitamin C encapsulation by nanoliposomes: production and evaluation of particle size, stability and control release

Amiri

Bari

Alizadeh-Khaledabad

et al. 2018

Food Sci Biotechnol

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In the present study, the effects of different ratios of milk phospholipids, cholesterol and phytosterols (Campesterol) powder (50-100%, 0-50%, and 0-50%, respectively) and sonication time (20, 25, 30, 35 and 40 min) were investigated to produce a new formulation of nanoliposomes for encapsulation of vitamin C. The results showed that increasing the time of sonication and decreasing the ratio of phospholipid to phytosterol significantly decreased nanoliposomes' particle size (p \ 0.05). The maximum encapsulation efficiency was obtained at 35 and 40 min of sonication time and 75-25 ratio of phospholipid: phytosterol. Also, reducing the sonication time in the same ratio of phospholipid/phytosterol caused to increase the controlled release. The highest stability of vitamin C during 20 days was obtained in the ratio of 75-25 (phospholipids: campesterol). The results showed a positive effect of cholesterol replacement with campesterol on encapsulation efficiency, control release and stability of vitamin C in nanoliposomes.

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Section: Liposome Stabilitymentioning

confidence: 96%

New formulation of vitamin C encapsulation by nanoliposomes: production and evaluation of particle size, stability and control release

Amiri

Bari

Alizadeh-Khaledabad

et al. 2018

Food Sci Biotechnol

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“…71,73,74 However, if cholesterol concentration exceeded certain limit, the entrapment percentage of drug significantly decreased owing to the disruption of the bilayer structure as observed in several studies especially if cholesterol concentration increased with the use of Span 60 or Span 40 surfactants in niosomes preparation. [75][76][77][78] Effects on the In Vitro Release Profile of Imatinib Mesylate From Niosomes…”

Section: Effect On the Entrapment Efficiency Of Im In Niosomesmentioning

confidence: 99%

Maximizing the Therapeutic Efficacy of Imatinib Mesylate–Loaded Niosomes on Human Colon Adenocarcinoma Using Box-Behnken Design

Kassem

El-Sawy

Abd-Allah

et al. 2017

Journal of Pharmaceutical Sciences

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This research purposed to formulate an optimized imatinib mesylate (IM)-loaded niosomes to improve its chemotherapeutic efficacy. The influence of 3 formulation factors on niosomal vesicular size (Y), zeta potential (Y), entrapment capacity percentage (Y), the percentage of initial drug release after 2 h (Y), and the percentage of cumulative drug release after 24 h (Y) were studied and optimized using Box-Behnken design. Optimum desirability was specified and the optimized formula was prepared, stability tested, morphologically examined, checked for vesicular bilayer formation and evaluated for its in vitro cytotoxicity on 3 different cancer cell lines namely MCF-7, HCT-116, and HepG-2 in addition to 1 normal cell line to ensure its selectivity against cancer cells. The actual responses of the optimized IM formulation were 425.36 nm, -62.4 mV, 82.96%, 18.93%, and 89.45% for Y, Y, Y, Y, and Y, respectively. The optimized IM-loaded niosomes confirmed the spherical vesicular shape imaged by both light and electron microscopes and further proven by differential scanning calorimetry. Moreover, the optimized formula exhibited improved stability on storage at 4 ± 2°C and superior efficacy on MCF7, HCT-116, and HepG2 as IC values were 6.7, 16.4, and 7.3 folds less than those of free drug, respectively. Interestingly, IC of the optimized formula against normal cell line was ranged from 3 to 11 folds higher than in different cancer cells indicating a higher selectivity of the optimized formula to cancer cells. In conclusion, the incorporation of IM in niosomes enhanced its efficacy and selectivity toward cancer cells, presenting a promising tool to fight cancer using this approach.

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“…Nowadays, most of the microencapsulation systems used in the food industry are biopolymer matrices based on polysaccharides, gums, proteins, synthetases, and other water‐soluble biopolymers (Li et al ., ). Based on research on liposomes for pharmaceutical and medical applications, food scientists have begun to use liposomes to control the delivery of functional ingredients such as proteins, enzymes, vitamins (Park et al ., ; Zhou et al ., ), antioxidants and fragrances (Pezeshky et al .,).…”

Section: Introductionmentioning

confidence: 99%

Co‐encapsulation of resveratrol and epigallocatechin gallate in low methoxyl pectin‐coated liposomes with great stability in orange juice

Feng

Sun

Wang

et al. 2019

Int J of Food Sci Tech

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To improve long-term stability of the liposomes, resveratrol (RES) liposomes, epigallocatechin gallate (EGCG) liposomes, RES+EGCG liposomes, RES+EGCG liposomes coated with low methoxyl pectin (LMP) were prepared, and their physical properties were evaluated. The prepared liposomes have a particle sizes of about 110-160 nm. The LMP-coated composite liposomes have the largest particle size and zeta potential, the latter indicating higher system stability. Liposome systems were pasteurised and placed in an orange juice system as to study liposome stability in a real the food environment. LMP bridge with metal ions forming a network-like gel in the LMP-coated composite liposomes, thereby enhancing the stability of liposomes. LMP-decorated liposomes could be developed as a formulation for encapsulating and delivering functional ingredients.Stability of complex liposomes in orange juice S. Feng et al.

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Vitamin A palmitate-bearing nanoliposomes: Preparation and characterization

Cited by 72 publications

References 37 publications

New formulation of vitamin C encapsulation by nanoliposomes: production and evaluation of particle size, stability and control release

New formulation of vitamin C encapsulation by nanoliposomes: production and evaluation of particle size, stability and control release

Maximizing the Therapeutic Efficacy of Imatinib Mesylate–Loaded Niosomes on Human Colon Adenocarcinoma Using Box-Behnken Design

Co‐encapsulation of resveratrol and epigallocatechin gallate in low methoxyl pectin‐coated liposomes with great stability in orange juice

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