Vitamin A Palmitate and Carbomer Gel Protects the Conjunctiva of Patients With Long-term Prostaglandin Analogs Application

Cui, Xinhan; Xiang, Jun; Zhu, Wenqing; Wei, Anji; Le, Qihua; Xu, Jianjiang; Zhou, Xiaodong

doi:10.1097/ijg.0000000000000316

Cited by 24 publications

(19 citation statements)

References 35 publications

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“…This is emphasized by the fact that all retrieved studies on the association of green leafy vegetables with OAG found a significant association [ 22 , 23 , 43 , 44 ]. Another benefit patients with glaucoma may have from vitamin A is that vitamin A protects the conjunctiva and relieves dry eye symptoms caused by long-term application of IOP-lowering eye drops [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamins on Glaucoma: A Systematic Review and Meta-Analysis

2018

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Background: The aim of is to determine the association of vitamins with glaucoma by performing a systematic review and meta-analyses. Methods: Studies on the relation of vitamins and glaucoma published up to December 2017 were identified in the PubMed and Embase database. Data on vitamins (method of assessment), glaucoma (type and method of assessment), study characteristics and quality were recorded. In case of multiple studies for one nutrient a meta-analysis was performed. Results: A total of 629 articles were identified of which 36 were included in the systematic review. The meta-analysis included five of them (940 open-angle glaucoma (OAG) cases and 123,697 controls in total) and resulted in an odds ratio [95% confidence interval] (OR [95% CI]) of 0.58 [0.37–0.91] for dietary vitamin A, though heterogeneity was high (I2 = 51%). After omitting studies that contributed significantly to the heterogeneity, the pooled OR [95% CI] was 0.45 [0.30–0.68] for dietary vitamin A on OAG (I2 = 0%). For vitamin B1, C and E no significant association with OAG was found (OR [95% CI]: 0.84 [0.47–1.51]; 0.68 [0.38–1.22]; 0.95 [0.75–1.19]; respectively). However, after addressing heterogeneity, vitamin C showed a protective effect as well. Especially, foods high in these vitamins (e.g., dark green vegetables) were protective for OAG. Conclusions: Dietary intake of vitamin A and C showed a beneficial association with OAG; however, findings on blood levels of vitamins do not show a clear relation with OAG.

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Section: Discussionmentioning

confidence: 99%

The Effect of Vitamins on Glaucoma: A Systematic Review and Meta-Analysis

2018

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“…Further studies are required to assess the specific effects of forskolin on both the ocular surface and intraocular pressure. In patients on long-term prostaglandin analogues, preliminary studies show that vitamin A palmitate and carbomer gel appeared to relieve dry eye symptoms by increasing conjunctival goblet cell density 88 , though larger studies are required for further assessment of this supplement.…”

Section: Management Of Ocular Surface Disease In Conjunction With Glamentioning

confidence: 99%

Ocular Surface Disease and Glaucoma Medications: A Clinical Approach

Zhang

Vadoothker

Munir

et al. 2019

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

115

100

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“…Vitamin A has been used topically to protect the conjunctiva of patients with glaucoma and has resulted in improvement in dry eye symptoms (Cui et al. ). This study should be extended to other dry eye patients.…”

Section: Future Studies and Challengesmentioning

confidence: 99%

Dry eye disease and oxidative stress

Seen

Tong

2017

Acta Ophthalmologica

219

162

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Dry eye, an age-related condition, is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance and tear film instability. Environmental factors are also often implicated in dry eye including exposure to pollutants, ultraviolet (UV) radiation and ozone as well as the chronic use of preserved eyedrops such as in the treatment of glaucoma. These factors increase oxidative stress and ocular surface inflammation. Here, we reviewed the cellular, animal and clinical studies that point to the role of oxidative stress in dry eye disease. The biomarkers used to indicate oxidative damage in ocular surface tissues include 8-hydroxy-2 deoxyguanosine (8-OHdG), 4-hydroxynonenal (HNE) and malondialdehyde (MDD). Antioxidative defences in the ocular surface occur in the form of tear proteins such as lactoferrin and S100A proteins, and enzymes such as superoxide dismutase (SOD), peroxidase, catalase and mitochondrial oxidative enzymes. An imbalance between the level of reactive oxygen species (ROS) and the action of protective enzymes will lead to oxidative damage, and possibly inflammation. A small number of interventional studies suggest that oxidative stress may be directly targeted in topical therapy of dry eye treatment. For example, in vitro studies suggest that L-carnitine and pterostilbene, a blueberry component may reduce oxidative stress, and in animal studies, alpha-lipoic acid (ALP) and selenoprotein P may be helpful. Examples of treatments used in clinical trials include vitamin B12 eyedrops and iodide iontophoresis. With recent emphasis on ageing medicine and preventive holistic health, as well as the role of environmental science, research on oxidative stress in the ocular surface is likely to have increasing impact in the coming years.

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Vitamin A Palmitate and Carbomer Gel Protects the Conjunctiva of Patients With Long-term Prostaglandin Analogs Application

Cited by 24 publications

References 35 publications

The Effect of Vitamins on Glaucoma: A Systematic Review and Meta-Analysis

The Effect of Vitamins on Glaucoma: A Systematic Review and Meta-Analysis

Ocular Surface Disease and Glaucoma Medications: A Clinical Approach

Dry eye disease and oxidative stress

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