Vitamin A: It's role in cosmeceuticals for antiaging

Abstract

Topical retinoids are among the most well‐studied and widely used cosmeceutical ingredients. Topical retinoids have skin rejuvenating benefits and can soften fine lines and wrinkles, lighten mottled hyperpigmentation, improve skin roughness, sallowness, and overall appearance of photoaged skin. Retinoic acid or tretinoin remains favored among dermatologists because there are a plethora of well‐designed clinical trials confirming its efficacy as a topical therapy for treating aging skin. In contrast, cosmeceutical retinoids are regulated as cosmetics and in general are not subjected to the same degree of scientific rigor as prescription retinoids. Despite this difference, there are studies confirming the antiaging benefits of cosmeceutical retinoids and studies comparing their efficacy and tolerability to tretinoin. This review will focus on over‐the‐counter retinoids including retinol, retinaldehyde, retinyl esters, adapalene, and novel retinoid molecules. Studies on pharmacokinetics, mechanisms of action, clinical benefits, and tolerability will be reviewed.

Vitamin C in dermatology and cosmetology: a review

“…These ROS radicals surge the process of cell damage, which in turn can cause alteration in the DNA, cell membrane and cell proteins like collagen. 3 Antioxidants can help neutralize the effects of ROS. Vitamin C helps in providing UV protection by not enabling the UV light to penetrate the skin, thereby reducing absorption of the UV light.…”

“…Therefore, topical use of vitamin C is usually preferred in dermatology practice. [2][3][4] The unavailability of L-glucono-gamma lactone oxidase, the primary enzyme required for in vivo synthesis of vitamin C in the human body makes it necessary to acquire vitamin C from other natural sources like citrus fruits, strawberries, broccoli, papaya, and green leafy vegetables. 3,4…”

Enhancing the Solubility, Stability, and Bioavailability of Retinol Acetate through Mechanochemistry

“…Retinol acetate (RA), a vital derivative of vitamin A, undergoes metabolic conversion to active vitamin A, playing a critical role in numerous physiological functions . Its benefits include protecting epithelial cells from radiation damage, , preventing skin aging, and inhibiting acne formation . RA has demonstrated superior efficacy compared to those of other vitamin A derivatives.…”